Stacey A Bélanger's research while affiliated with CHU Sainte-Justine and other places

Publications (24)

Article
The SET domain containing 2, histone lysine methyltransferase encoded by SETD2 is a dual‐function methyltransferase for histones and microtubules and plays an important role for transcriptional regulation, genomic stability, and cytoskeletal functions. Specifically, SETD2 is associated with trimethylation of histone H3 at lysine 36 (H3K36me3) and m...
Article
Full-text available
Objective: Primary care practitioners determine access to care for many preschool children with mental health (MH) problems. This study examined rates of mental health (MH) problem identification in preschoolers within primary healthcare settings, related service use, and MH status at follow-up. The findings may inform evidence-based policy and pr...
Article
Le trouble de déficit de l’attention/hyperactivité (TDAH) est un trouble neurodéveloppemental chronique. La Société canadienne de pédiatrie a préparé trois documents de principes après avoir effectué des analyses bibliographiques systématiques. Leurs objectifs s’établissent comme suit : • 1) Résumer les données probantes cliniques à jour sur le TD...
Article
Attention-deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder. Three position statements have been developed by the Canadian Paediatric Society, following systematic literature reviews. Statement objectives are to: • 1) Summarize the current clinical evidence regarding ADHD, • 2) Establish a standard for ADHD care, and •...
Article
Le trouble de déficit de l’attention/hyperactivité (TDAH) est un trouble neurodéveloppemental chronique. La Société canadienne de pédiatrie a préparé trois documents de principes après avoir effectué des analyses bibliographiques systématiques. Leurs objectifs s’établissent comme suit : • 1) Résumer les données probantes cliniques à jour sur le TD...
Article
Le trouble de déficit de l’attention/hyperactivité (TDAH) est un trouble neurodéveloppemental chronique. La Société canadienne de pédiatrie a préparé trois documents de principes après avoir effectué des analyses bibliographiques systématiques. Leurs objectifs s’établissent comme suit : • 1) Résumer les données probantes cliniques à jour sur le TD...
Article
Attention-deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder. Three position statements have been developed by the Canadian Paediatric Society, following systematic literature reviews. Statement objectives are to: • 1) Summarize the current clinical evidence regarding ADHD, • 2) Establish a standard for ADHD care, and •...
Article
Attention-deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder. Three position statements have been developed by the Canadian Paediatric Society, following systematic literature reviews. Statement objectives are to: • 1) Summarize the current clinical evidence regarding ADHD, • 2) Establish a standard for ADHD care, and •...
Article
Global developmental delay (GDD) and intellectual disability (ID) are common concerns in the paediatric setting. Etiologies of both conditions are highly heterogeneous. The American Academy of Pediatrics, the American Academy of Neurology and the British Columbia-based Treatable Intellectual Disability Endeavor (TIDE) protocol have each proposed mu...
Article
Le retard global du développement (RGD) et le handicap intellectuel (HI) font partie des problèmes courants en milieu pédiatrique. Leur étiologie est très hétérogène. L’American Academy of Pediatrics, l’American Academy of Neurology et le protocole Treatable Intellectual Disability Endeavor (TIDE) de la Colombie-Britannique préconisent des explorat...
Article
Full-text available
Disruptive behaviour problems in preschool children are significant risk factors for, and potential components of, neurodevelopmental and mental health disorders. Some noncompliance, temper tantrums and aggression between 2 and 5 years of age are normal and transient. However, problematic levels of disruptive behaviour, specifically when accompanie...
Article
Full-text available
Chez les enfants d’âge préscolaire, les comportements perturbateurs sont d’importants facteurs de risque et des éléments potentiels de troubles du neurodéveloppement et de la santé mentale. Entre l’âge de deux et cinq ans, il est normal d’observer des comportements transitoires comme un certain défaut de se conformer, des crises de colère et de l’a...
Article
Disruptive behaviour problems in preschool children are significant risk factors for, and potential components of, neurodevelopmental and mental health disorders. Some non-compliance, temper tantrums and aggression between two and five years of age are normal and transient. However, problematic levels of disruptive behaviour, specifically when acco...
Article
Full-text available
Disruptive behaviour problems in preschool children are significant risk factors for, and potential components of, neurodevelopmental and mental health disorders. Some non-compliance, temper tantrums and aggression between two and five years of age are normal and transient. However, problematic levels of disruptive behaviour, specifically when acco...
Article
Mental health in children with neuromotor disorders is part of a dynamic system, including medical and developmental domains, family, school and community. Presentations are often complex and multifactorial, requiring a broad, individualized approach. A narrative overview of mental health symptoms in children with neuromotor disabilities is provide...
Article
Full-text available
Suicide is a leading cause of death among Canadian adolescents. The present practice point provides paediatricians and child health professionals with a framework for assessing the adolescent with suicidal thoughts and/or behaviours. The epidemiological context, general considerations and practical suggestions for how to approach the suicidal adole...
Article
To develop evidence-based guidelines on pharmacotherapy for severe disruptive and aggressive behaviour in children and adolescents with attention-deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), or conduct disorder (CD). The guidelines assume that psychosocial interventions have been pursued but did not achieve sufficient...
Article
Background/objective: Antipsychotic use in children is increasing. The purpose of the present article is to provide guidance to clinicians on the clinical management of extrapyramidal side effects of second-generation antipsychotics. Methods: Published literature, key informant interviews, and discussions with panel members and stakeholder partn...
Article
The rising international trend in the number of parents who separate or divorce is raising concerns about longterm consequences for child and youth well-being and adjustment to adulthood. Separation and divorce may increase risks for negative outcomes in physical, mental, educational and psychosocial well-being during childhood and later, as youth...
Article
BACKGROUND/OBJECTIVE: Antipsychotic use in children is increasing. The purpose of the present article is to provide guidance to clinicians on the clinical management of extrapyramidal side effects of second-generation antipsychotics. METHODS: Published literature, key informant interviews, and discussions with panel members and stakeholder partners...
Article
HISTORIQUE ET OBJECTIF L’utilisation d’antipsychotiques augmente chez les enfants. Le présent article visait à orienter les cliniciens quant à la prise en charge clinique des effets secondaires extrapyramidaux des antipsychotiques de deuxième génération. MÉTHODOLOGIE Les publications, les entrevues avec des informateurs clés et des échanges avec l...
Article
BACKGROUND: The use of antipsychotics, especially second-generation antipsychotics (SGAs), for children with mental health disorders in Canada has increased dramatically over the past five years. These medications have the potential to cause major metabolic and neurological complications with chronic use. OBJECTIVE: To synthesize the evidence for s...
Article
Full-text available
Background/objective: Antipsychotic use in children is increasing. The purpose of the present article was to provide guidance to clinicians on the clinical management of extrapyramidal side effects of second-generation antipsychotics. Methods: Published literature, key informant interviews, and discussions with panel members and stakeholder part...
Article
BACKGROUND: Second-generation antipsychotics are commonly associated with metabolic complications. These medications are being used more frequently for the treatment of mental health disorders in children, which has stimulated the need for creating formal guidelines on monitoring their safety and effectiveness. Previous guidelines have been develop...

Citations

... De novo mono-allelic SETD2 mutations have been found in ASD patients and Sotos-like syndrome with autism phenotypes. 9,[15][16][17][18][19][20][21][22][23] Given the vast majority of ASD-linked mutations in chromatin remodelers occur in only one allele, pathogenicity is ascribed to either dominantnegative activity of the mutant allele or haploinsufficiency associated with monoallelic loss of function. [40][41][42][43] Both dominant-negative effects on the epigenome (e.g. ...
... Mental health screenings by community practitioners show a comparable but not identical detection rate of mental health problems in young children as diagnostic tools used by experts (Charach et al., 2020). There is a wide array of mental health assessment approaches for young children (Szaniecki & Barnes, 2016), but not all of them are available in German. ...
... Individuals diagnosed with ADHD often display negative behaviors (e.g. interrupting) that hinder their social abilities (Clark and Belanger, 2018); whereas those diagnosed with ASD often lack positive behaviors such as limited eye contact, which impairs their social skills (Antshel and Russo, 2019;APA, 2013). Other overlapping symptoms are harder to differentiate such as responses to sensory stimuli, though still an emerging area of research. ...
... Toutefois, chez certains jeunes, des effets secondaires considérables associés à la prise de médication sont documentés tels que des troubles de l'humeur et du sommeil ainsi qu'une perte d'appétit importante (Feldman et al., 2018). À cet égard, le Journal de Québec a publié le 31 janvier 2019 une lettre signée par 45 pédiatres qui signalent la surmédication des jeunes ayant un diagnostic de TDAH au Québec (Dion-Viens, 2019). ...
... Un autre facteur peut expliquer ces chiffres : la diminution de la stigmatisation de la psychiatrie connue pour être un grand frein pour la demande de soin en santé mentale ; facteur favorisé par la localisation du service dans un hô pital gé né ral [11]. Dans notre é tude, la tranche d'âge dominante é tait entre 6 et 11 ans comme dans d'autres travaux [14,38] Nous pouvons l'expliquer par le fait que plusieurs pathologies pé dopsychiatriques telles que le handicap intellectuel, les troubles spé cifiques des apprentissages et le trouble dé ficit de l'attention/hyperactivité sont fré quemment diagnostiqué es ou ré vé lé es lors de l'entré e à l'é cole primaire [6]. Par ailleurs, les adolescents repré sentaient le quart des consultants, proportion rapporté e é galement dans d'autres travaux [9,14,23,24,48]. ...
... This category includes all first-line ADHD medications recommended by the Canadian Paediatric Society. 29 We also evaluated 2 or more dispensations of N06B medications as a secondary outcome. We classified infant deaths as having experienced the outcome to avoid selection bias (i.e., infants who did not receive corticosteroids may not have survived to develop ADHD). ...
... ADHD is one of the most common disorders in children, characterized by hyperactivity, inattention, and impulsivity. Studies suggest that approximately 50% of ADHD patients suffer from at least one other psychiatric disorder, including oppositional defiant disorder, conduct disorder, depression, anxiety disorders, and learning disabilities (Bélanger et al. 2018). The serotonergic hypothesis of ADHD suggests that chronic reductions in availability of 5-HT are associated with the clinical manifestations of ADHD. ...
... La Société canadienne de pédiatrie publie sur son site internet un document de principe basé sur Bélanger et Caron (2018). ...
... is case highlights the challenges in diagnosing genetic and metabolic conditions in the growing immigrant population in Canada [5]. A position statement reviewed by the Community Pediatrics Committee includes a stepwise guide to children with developmental delay which includes formal vision and hearing testing, chromosomal microarray, and first-tier testing for treatable inborn errors of the metabolism [6]. ...
... The consequences of untreated externalizing behavior problems during early childhood are significant. In the short term, behavioral problems can interfere with children's ability to participate successfully when they enter school, placing them at risk for poorer academic outcomes [41]. In the long term, behavioral problems could affect physical and mental health outcomes in later life [42,43]. ...