Sophie Adamantos's research while affiliated with University of Bristol and other places

... In a study by Horgan et al. (2009), ten dogs with IMHA that underwent splenectomy, had an increase in hematocrit three days post-surgery and needed less frequent blood transfusions post-surgery. In another study, four out of seven dogs with IMHA had a partial or complete response to treatment after splenectomy (Bestwick et al., 2022). These outcomes could have been influenced by response to the immunosuppressive therapy since most dogs in both studies were treated in the acute phase of IMHA. ...

... However, it should be noted that PDS, which is commonly used for the treatment of IMPA, can induce proteinuria and glomerular changes in dogs (26). Recent studies have shown that proteinuria occurs more frequently in dogs with IMPA, and significant proteinuria is completely resolved after resolution of IMPA despite PDS treatment (1,24). This suggested that PDS therapy might worsen proteinuria but resolves it by treating the underlying diseases (1,10). ...

... 44 A hypercoagulable state has also been detected by thromboelastography in dogs with normoalbuminemic and hypoalbuminemic chronic inflammatory enteropathy. 46 The relationship between proteins in our study was mapped using the STRING algorithm (Figure 3), and the findings were dominated by the involvement of ECM proteins. ECM remodeling is a hallmark of IBD in humans. ...

... Cats with feline dysautonomia may present with clinical signs such as anorexia or hyporexia (92%), vomiting or regurgitation (85%), constipation (55%), nasal discharge or crusting (46%), lower urinary tract signs (43%), respiratory signs (37%), bradycardia (30%), altered anal tone (20%) and diarrhea (16%). 11 Specific There is a marked decrease in immunoreactivity highlighting neuronal dropout. (b) Celiac ganglion (GFAP) in 1-year-old cat (not age-matched) with normal neuronal density and no microscopic abnormalities ocular signs also occur in cats with dysautonomia, including reduced lacrimation (90%), absent or delayed PLR (88%), mydriasis (81%) and third eyelid protrusion (77%). ...

... There may be important contextual and practical reasons why a particular decision was made. Exploration of these factors may be used to refine future decision making, including policies and protocols, as occurs in root cause analysis of medical errors (70,71). All veterinary team members have a role in steering away from a culture of blame -which acts as a barrier to reporting and appropriate debriefing, and promoting a culture of learning from errors (72). ...

... Thymic hematoma, with or without subsequent hemorrhage, is poorly understood and uncommon in animals, with few cases having been reported in dogs only (Klopfer et al. 1980;Klopfer et al. 1985;van der Linde-Sipman and van Dijk 1987;Coolman et al. 1994;Liggett et al. 2002;Stallwood et al. 2019). In some cases, the causes were identified as being the result of vehicular trauma, dissecting aortic aneurysm, or rodenticide intoxication (van der Linde-Sipman and van Dijk 1987; Liggett et al. 2002); most cases were determined to be idiopathic or of spontaneous occurrence in young animals (Klopfer et al. 1980;Klopfer et al. 1985;van der Linde-Sipman and van Dijk 1987;Coolman et al. 1994;Stallwood et al. 2019). ...

... SRMA describes the most common type of canine meningitis (Meric, 1988). Furthermore, it represents the most frequent diagnosis of dogs presented with cervical hyperaesthesia (Grapes et al., 2020) and pyrexia, including juvenile dogs up until 18 months of age (Black et al., 2019). Basically, SRMA can occur at any age, but juvenile and young-adult dogs are mainly affected by this disease between the age of 6 and 18 months (Cizinauskas et al., 2000;Tipold and Schatzberg, 2010). ...

... Multiple acquired shunts (MAS) have been reported in up to 20% of dogs following surgical treatment of their CPSS [3,6,11], and there is minimal information to suggest whether the method or degree of shunt attenuation is associated with the development of MAS. Post-attenuation neurological signs (PANS) have been reported to occur in up to 12% of dogs undergoing surgical treatment of a CPSS [11][12][13][14][15][16][17]. Method or degree of extrahepatic shunt attenuation has not been shown to be a risk factor for PANS [18]. ...

... In a case report published in 2018, Black and colleagues [123] used, for the first time, proteomics technologies to investigate the proteome of the RBCs in a dog suffering from hemolytic anemia neither immunomediated nor caused by toxins or infectious agents. They identified 408 proteins and, comparing them with the proteomic profile of a healthy dog, they found out that 252 of these showed increased or decreased levels in the affected dog. ...

... 13,28 Prognosis following lung lobectomy for LLT is described to be good in small animals, with all cats undergoing lobectomy reported in the veterinary literature surviving to discharge and 86-95% of dogs surviving to discharge. [1][2][3]6,24,29,30 In this study the outcome following surgical management of LLT was poor for 7/10 cases. This appears higher than previously reported. ...