Solmaz Esnaashari's research while affiliated with Tabriz University of Medical Sciences and other places

Publications (12)

Article
Full-text available
Purpose: Breast cancer is the most frequent malignancy diagnosed in women both in developed and developing countries. Natural products especially those from herbal origin have high potential in producing drug components with a source of novel structures. The present study was designed to explore the cytotoxic effects and the cell death mechanism of...
Article
Full-text available
Phytochemical analysis of the methanolic and dichloromethane extracts of the aerial parts of Scutellaria pinnatifida led to the isolation of a phenylpropanoid, 1-o-feruloyl-ß-D-glucose [1], two known flavonoids including luteolin-7-o-glucoside (2) and apigenin-7-o-glucoside (3), three known phenylethanoid glycosides composed of phlomisethanoside (4...
Article
Background: In this investigation, we aimed to purify and elucidate compounds from Spatoglossum asperum J. Agardh (Dictyotaceae). Moreover, general toxicity, anti-proliferative, antibacterial and antioxidant properties of crude extracts were studied. Methods: The extract was isolated by petroleum ether (PE), dichloromethane (DCM) and methanol (MeOH...
Article
Background: Adiantum capillus-veneris (Adiantaceae) is the only species of Adiantum genus growing in Iran. As a well-known plant in Iranian Traditional Medicine, to our knowledge, there has not been any report on essential oil constituents of this species as well as antioxidant activity evaluation of any plant belonging to Adiantum genus. Objective...
Conference Paper
Background: Cancer is one of the most prevalent diseases worldwide which is a major public health issue in both developed and developing countries. Recent studies have shown that, medicinal plants are potential agents for cancer therapy .The present study was designed to explore the cytotoxic effects and the cell death mechanism of dichloromethane...
Article
Full-text available
The essential oils of the aerial parts of A. armeniaca and A. incana, collected from Arasbaran area (East Azarbaijan province, Iran) were extracted by hydrodistillation and analyzed by GC-MS. In total, 16 and 40 constituents were identified and quantified in the oils of A. armeniaca and A. incana representing 80.5% and 84.6% of the oils, respective...
Article
The essential oil of Rheum ribes L. stalks and flowers, growing in Iran, were extracted with hydro-distillation and analyzed by GC-MS. Thirty constituents representing 93.84% of Rheum oil were identified. The oil was found to be rich in hydrocarbons especially long-chain n-alkanes (80.81%). The most abundant components in the oil included tricosane...
Article
Background: The present study is designed to evaluate the radical scavenging activity, total phenol content (TPC) and total flavonoid content (TFC) of the MeOH extracts and their solid phase extraction fractions of A. spicigera and A. splendens. Methods: The antioxidant activity of the extracts and fractions were examined by DPPH method. Total phen...
Article
Full-text available
Seven free-radical-scavenging phenolic compounds including five flavonoids, rutin (1), chrysoeriol 7-O-rutinoside (2), kaempferol 3-O-glucoside (3), chrysoeriol 7-O-glucoside (4) and naringenin (5), and two phenylethanoid glycosides, forsythoside B (6) and acteoside (7) were isolated from the methanol extract of the aerial parts of the Iranian medi...
Article
Full-text available
Artemisia is a fairly large genus within the family Asteraceae (alt. Compositae), with ca. 300 individual species of aromatic and medicinal plants, which are usually found as small fragrant shrubs or herbs in the northern hemisphere [1, 2]. While some of their essential oils are used in perfumery and medicine, the leaves of some species are used as...
Article
A combination of vacuum liquid chromatography (VLC) and preparative thin layer chromatography (PTLC) of the dichloromethane extract of the aerial parts of the Iranian plant Pimpinella aurea afforded two phenylpropanoids, erythro-1'-(4-methoxyphenyl)-propan-1',2'-diol (1) and erythro-1'-[4-(sec-butyl)-phenyl]-propan-1',2'-diol (2), the latter being...
Article
Solid dispersions can be used to improve dissolution of poorly soluble drugs and PVP is a common polymeric carrier in such systems. The mechanisms controlling release of drug from solid dispersions are not fully understood and proposed theories are dependent on an understanding of the dissolution behaviour of both components of the dispersion. This...

Citations

... The cysteine protease activation, particularly caspases, is a crucial intracellular regulator of cell apoptosis(80). CASP 3 and CASP 9 genes belong to the cysteine-aspartic acid protease family and play a central role in inducing apoptosis(81). Alenzi, Alenazi, Al-Anazy, Mubaraki, Salem, Al-Jabri, Lotfy, Bamaga, AlRabia and Wyse (82) stated that caspase 3 has a substantial arbitrator of apoptosis. ...
... Kaempferol was reported to be richer in leaves of rust-susceptible M. sylvaticum compared to those of rust-resistant M. pratense recently (Kaitera & Witzell, 2016). 1-O-feruloyl-beta-D-glucose is a natural product having a role as an antioxidant and a plant metabolite (Arnaldos et al., 2001;Delazar et al., 2017;Du et al., 2006;Jia et al., 2017). Luteolin 7-O-(6"-malonylglucoside) is a trihydroxyflavone. ...
... PCA confirmed that S. asperum contained high TPC content and, therefore, high anti-proliferation of HeLa cells ( Figure 5). The edible brown seaweed S. asperum is considered a potential source of natural antioxidant molecules and different bioactive metabolites [47,56,57]. ...
... According to the previous studies, phenolic compounds, glycosides, sterols, steroids, resins, alkaloids, flavonoids, fatty acids, coumarins, and vitaminsare the most important secondary metabolites in R. ribes [7][8][9][10]. Indeed, this variety of compounds in R. ribes are responsible to wide spectrum of pharmaceutical uses of the plant [11][12][13][14] Today, the use of nanomaterials is increasing widely, so it has been introduced in all aspects of life, and in the meantime, the use of nanocomposites in medical processes has also found an increasing use. Nanoparticles have various applications in medicine, including prevention and treatment of diseases, nano robots for diagnosis, various medical sensors, imaging and drug delivery system [11][12][13]. ...
... Chemically, maidenhair fern contains tannins, terpenoids, flavonoids, alkaloids, and steroids (Khodaie et al. 2015). Roots, rhizomes, and the fronds of the ACVL plant have several medicinal effects which include anti-inflammatory, analgesic, antioxidant, detoxifying agent wound healing, anti-diarrheal, anti-bacterial, anti-fungal, anti-diabetic, hypocholesterolemic, anti-asthmatic, anti-spasmodic, diuretic, and anti-urolithiasis (Dehdari and Hajmehdipoor 2018). ...
... Many species of wormwood, in particular Artemisia absinthium, Artemisia dracunculus, Artemisia santonicum, and Artemisia spicigera, are successfully used in medicine [3]. It has been established that different types of wormwood differ significantly in chemical composition and pharmacological properties, as well as in the degree of toxicity [4]. Therefore, it is necessary to conduct a study of the chemical composition of various representatives of the genus Artemisia to identify the prospects for their medical use. ...
... Seven free radical scavenging phenolic compounds, comprising five flavonoids, rutin, chrysoeriol 7-O-rutinoside, kaempferol 3-O-glucoside, chrysoeriol 7-O-glucoside, and naringenin, were identified by HPLC from the aerial portions of the Iranian medicinal plant Phlomis caucasica Rech. [56]. To carry out this analysis, two preparations were the subject of this study. ...
... In the rural area of Khoy, people use the Artemisia plant as a broom because of its resilience, its pleasant aroma lingering in the air, and its ability to repel insects and vermin. Until now, there are several reports on the composition of EOs of this plant and their antimicrobial effects in Iran [14,16,[19][20][21][22][23] and other countries. [24,25] While A. fragrans is a perennial plant, Khoy's locals usually harvest the plant from its roots for their applications. ...
... Thus, the improvement of ibuprofen dissolution for its immediate release is desirable for rapid ibuprofen absorption, �hich is prerequisite for quick onset of its pharmacological actions. In the previous literature, various solid dispersions of ibuprofen are reported for improving its dissolution using various carriers (Xu et al., 2007;Ali & Sharma, 1991;Khan & Jiabi, 1998;Esnaashari et al., 2005;Loganathan et al., 2000;Ne�a et al., 2007;Ne�a et al., 2008a;Ne�a et al., 2008b;Ne�a et al., 2008c;Islam et al., 2010;Park et al., 2009;Dabbagh & Taghipour, 2007). Polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) are amongst the most frequently investigated hydrophilic polymeric carriers (Kalaiselvan et al., 2006;Wade & Paul, 1994;Kaur et al., 1980;Broman et al., 2001;Trantishaiyakul et al., 1991). ...