Sohail Z. Husain’s research while affiliated with STANFORD CHILDREN'S HEALTH HOSPITAL and other places

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Publications (203)


Why is the rectal route for NSAIDS favorable for preventing post-ERCP pancreatitis?
  • Article

February 2025

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11 Reads

Pancreatology

Gayathri Swaminathan

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Yu-Chu Lin

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[...]

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Sohail Z. Husain

Potential mechanisms involved in the pathogenesis of post‐ERCP pancreatitis. TRPV1, Transient receptor potential vanilloid 1. Source: Adapted with permission from Johns Hopkins University.
(A) Electron microscopy view of the major duodenal papilla demonstrating mucosal duplications. (B) Endoscopic view of the major papilla*. (C) Guidewire and sphincterotome trapped within the cul‐de‐sacs under the tongue shaped mucosal flaps within the duodenal papilla or ampulla#. Source: *Adapted with permission from Paulson et al. [13]. # From Johns Hopkins University.
Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis: Novel Mechanisms and Prevention by Drugs
  • Literature Review
  • Full-text available

December 2024

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41 Reads

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1 Citation

Endoscopic retrograde cholangiopancreatography (ERCP) is becoming more common than first‐line therapy for pancreaticobiliary duct disorders. However, post‐ERCP pancreatitis is the most common complication of ERCPs, and affects about 10% of cases. In this review, we provide an overview of the mechanisms purported to cause post‐ERCP pancreatitis as well as associated risk factors. We discuss measures that are in practice for post‐ERCP pancreatitis pharmaco‐prophylaxis, along with advances in the pipeline. We emphasize that there is still a pressing need to narrow the incidence of post‐ERCP pancreatitis and that a mechanistic approach may reveal the greatest benefit from utilizing a combination of targets.

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Figure 2. Continued.
Exploiting open source omics data to advance pancreas research

February 2024

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8 Reads

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1 Citation

Journal of Pancreatology

The “omics” revolution has transformed the biomedical research landscape by equipping scientists with the ability to interrogate complex biological phenomenon and disease processes at an unprecedented level. The volume of “big” data generated by the different omics studies such as genomics, transcriptomics, proteomics, and metabolomics has led to the concurrent development of computational tools to enable in silico analysis and aid data deconvolution. Considering the intensive resources and high costs required to generate and analyze big data, there has been centralized, collaborative efforts to make the data and analysis tools freely available as “Open Source,” to benefit the wider research community. Pancreatology research studies have contributed to this “big data rush” and have additionally benefitted from utilizing the open source data as evidenced by the increasing number of new research findings and publications that stem from such data. In this review, we briefly introduce the evolution of open source omics data, data types, the “FAIR” guiding principles for data management and reuse, and centralized platforms that enable free and fair data accessibility, availability, and provide tools for omics data analysis. We illustrate, through the case study of our own experience in mining pancreatitis omics data, the power of repurposing open source data to answer translationally relevant questions in pancreas research.



Citations (58)


... Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal digestive system tumors [1][2][3] . ...

Reference:

Influences of Intraoperative Warming on Surgical Outcomes of Pancreaticoduodenectomy With Portal Vein Reconstruction: A Retrospective Cohort Study
Exploiting open source omics data to advance pancreas research

Journal of Pancreatology

... Studying the pathophysiological mechanisms of inflammatory pancreatic diseases in humans is challenging due to the inaccessibility and risks of pancreatic tissue samples. Recent studies have shown that pancreatic inflammatory responses and immunological mechanisms can be characterized by analyzing immune signatures in the systemic circulation 8, [29][30][31] . We hypothesize that patients with CP at different clinical stages (suspected vs. definitive CP according to the M-ANNHEIM criteria) have distinct concentrations of systemic macrophage-specific biomarkers. ...

Distinct serum immune profiles define the spectrum of acute and chronic pancreatitis from the multi-center PROCEED study
  • Citing Article
  • April 2023

Gastroenterology

... [55] Additionally, preclinical intraductal delivery of calcineurin inhibitor formulations was safe and well tolerated in mice. [56] This initial work has led to human clinical trials. One prospective pilot study involved patients who had undergone ERCP; patients were randomized into a control group and a group receiving tacrolimus at 8 pm on the day preceding ERCP and at 8 am on the day of ERCP. ...

Preclinical safety evaluation of calcineurin inhibitors delivered through an intraductal route to prevent post-ERCP pancreatitis demonstrates endocrine and systemic safety
  • Citing Article
  • March 2023

Pancreatology

... Unfortunately, the GBD lumps together the three subtypes, thus making trends in incidence versus prevalence more challenging to interpret. Are the baseline differences among regions for pediatric pancreatitis from the GBD, or the trends within regions, associated with genetic predisposition or environmental exposures, for example, from nutritional deficiencies, 10 that are implicated with pancreatitis susceptibility? ...

A systems approach points to a therapeutic role for retinoids in asparaginase-associated pancreatitis
  • Citing Article
  • March 2023

Science Translational Medicine

... In contrast to experimental pancreatitis models that have been used for decades, investigation of GEMMs associated with mutations in the trypsin-dependent pathway has started only recently [13,[38][39][40][41][42][43][44][45][46][47][48][49][50]. As illustrated in Table 1, there are numerous gaps in our current knowledge on whether and to what extent the basal pancreatic trypsin activity increases in these models (see the discussion below in "The role of trypsin in HP-related GEMMs"). ...

Genetically Engineered Mouse Models Shine New Light on Decades-old Story of Trypsin in Pancreatitis
  • Citing Article
  • February 2023

Gastroenterology

... better" was not considered a positive response Kozarek et al 27 Pancreatitis episodes per year Change in chronic pain Coleman et al 28 A questionnaire asking about frequency and severity of pain before and after the procedure Lehman et al 28 Clinical improvement was assessed by comparison of symptoms (using a 0 to 10 scale) and number of hospital days per month required for pain or pancreatitis for an equal period of time before and after therapy Lans et al 30 The effectiveness of treatment was documented using the questionnaire method during each visit or telephone conversation. The following criteria were evaluated: (1) the number of hospitalizations and emergency room visits for abdominal, (2) the number of documented episodes of acute pancreatitis, and (3) patients' overall general feeling was graded on the visual analog scale Siegel et al 31 NA Satterfield et al 32 Reduction of symptom score and number of hospitalizations Mccarthy et al 33 Fewer attacks of pancreatitis, and fewer visits to the emergency room Zhang et al 34 Success rate represented the technical success rate of ERCP, which meant ERCP procedures, such as MiES and EDSi, were performed as planned Barakat et al 35 Fewer pancreatitis episodes, less baseline pain, and overall more mild pancreatitis-associated symptoms pooled rate of adverse events was 24% (95% CI: 17-32, I 2 = 85%). All results along with the adverse event subtypes are summarized in Table 3. Supplementary Figures 6 to 12, Supplemental Digital Content 1, http://links.lww.com/JCG/ ...

Safety and efficacy of minor papillotomy in children and adolescents with pancreas divisum
  • Citing Article
  • December 2022

Pancreatology

... 6 However, multiple studies since then have shown inconsistencies with this initial assertion, including a German study from 1986 in which patients with severe EPI (lipase <10%) were found to have normal fat excretion whereas other patients with moderate disease had steatorrhea. 7 Regardless of the severity of EPI, reduction of pancreatic enzyme secretion in an individual can result in malabsorption of nutrients, which subsequently requires intervention to restore effective nutrient digestion and absorption. There are a multitude of etiologies of EPI that can result via inadequate synthesis and secretion of pancreatic enzymes, decreased pancreatic stimulation, pancreatic ductal obstruction, and decreased pancreatic enzyme activity in the small bowel. ...

AGA-PancreasFest Joint Symposium on Exocrine Pancreatic Insufficiency
  • Citing Article
  • November 2022

Gastro Hep Advances

... Further causes for pancreatitis, such as a history of endoscopic retrograde cholangiopancreatography, hypercalcemia, hypertriglyceridemia, infections, genetics, autoimmune diseases, and trauma were not present in the patient. In addition, many drugs are reported to induce pancreatic damage [15]; however, pancreatitis associated with intake of tizanidine. zolpidem and mirtazapine occurred either shortly after initiation of the drugs [16] or with concomitant precipitating disorders, such as alcohol abuse or hypertriglyceridemia [17,18]. ...

Clinical insights into drug-associated pancreatic injury
  • Citing Article
  • September 2022

Current Opinion in Gastroenterology

... Moreover, the pancreatic expression of calcineurin mediates pancreatic necroptosis. This emphasizes the function of calcineurin and its potential as a target for calcineurin inhibitor-based PEP prophylaxis [47,48]. ...

Rectal INdomethacin, oral TacROlimus, or their combination for the prevention of post-ERCP pancreatitis (INTRO Trial): Protocol for a randomized, controlled, double-blinded trial
  • Citing Article
  • July 2022

Pancreatology

... 34 However, early diagnosis and sufficient management are central to avoid diabetic complications. 35 Persisting IDDM is a known long-term sequelae to AP and AAP (Figure 1), 10,36 and is classified as type 3c diabetes mellitus (T3cDM), although patients with T3cDM are often misdiagnosed as having type 2 diabetes. 27 In a large pediatric cohort of non-ASNase AP, 7.7% of patients were diagnosed with IDDM within 6 years from AP diagnosis. ...

Multidisciplinary Approach to the Care of Children With Acute Recurrent Pancreatitis and Chronic Pancreatitis
  • Citing Article
  • March 2022

Pancreas