Sirous Dehghani's research while affiliated with Isfahan University of Medical Sciences and other places
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Publications (4)
Although several animal and human studies have investigated the effect of alpha-lipoic acid (ALA) on blood pressure (BP), these findings are inconsistent. This systematic review of randomized clinical trials was conducted to summarize the evidence on the effect of ALA on BP. PubMed, SCOPUS, and Google Scholar databases were searched based on MESH t...
Background
Although several studies have investigated the association between ovarian cancer risk and nonisoflavone flavonoids intake, these findings are inconsistent. This systematic review of published epidemiological studies was conducted to summarize and clarify the evidence on the association between ovarian cancer incidence and nonisoflavone...
Study design:
A randomized, double-blind, placebo-controlled clinical trial.
Objective:
To assess the effect of alpha-lipoic acid (ALA) supplementation on IL-6, hs-CRP, FBS, anthropometric indices, food intake and blood pressure in male patients with chronic spinal cord injury (SCI).
Setting:
Imam Khomeini Hospital, Tehran University of Medica...
Citations
... It is synthesized by the liver [2] and is present in animal and vegetable sources [3]. The antioxidant effect of ALA has been demonstrated by the ability of ALA to clear reactive oxygen species (ROS) and activating the endogenous antioxidant system [4,5]. Additionally, it has been shown that ALA could improve endothelium function and play a role in nitric oxide synthesis [6,7]. ...
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... al., 2017, this structure appears as the most abundant phenolic acid in the AH extracts. Further, it can be observed some flavanols (catechin (Sang et al., 2002) and epicatechin), both useful as anti-obesity agents (Akhlaghi et al., 2018), as well as flavonoids (3-hydroxyphloretin), which showed several benefits against ovarian cancer (Mohammadi et al., 2016). Moreover, other glycosylated, as kaempferol 3,7-O-diglucoside, were detected. ...
... Although healthy young humans can synthesize enough a-lipoic acid to scavenge reactive oxygen species and to enhance endogenous antioxidant activity, the level of a-lipoic acid significantly declines with age contributing to endothelial dysfunction [114]. Despite some promising preclinical and clinical data, a recent meta-analysis of nine studies (seven parallel-designed trials and two crossover-designed trials) concluded that there is a limited evidence supporting a BP-lowering effect of supplemented alipoic acid [115]. The safety profile was similar to placebo. ...
... A 7-month nutritional education with personalized diet in otherwise healthy SCI individuals did not influence blood pressure, lipid profile or anthropometric measurements (44). A clinical trial comparing a 12-week intervention with 600 mg of alpha-lipoic acid (ALA) supplementation and placebo reported a significant decrease in fasting glucose, waist circumference, BMI, and blood pressure in the intervention arm as compared to the control group; no differences were observed in high sensitivity c-reactive protein (hs-CRP) and IL-6 between the groups (45). Another RCT supplementing creatine (3 g/day) and vitamin D (25000 IU every two weeks) for eight weeks, accompanied by progressive resistance training, led to decreased skinfold thickness (46). ...
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