Simone Shamay-Tsoory's research while affiliated with University of Haifa and other places

Publications (49)

Article
Full-text available
Theory of Mind (ToM), a high-order human social cognition skill, is relevant for mental health and wellbeing and frequently impaired in many clinical conditions. To detect ToM difficulties, validated and standardized measures need to be adopted in clinical practice. The Yoni task provides a comprehensive evaluation of first-order, second-order, aff...
Article
Full-text available
Objective: To investigate the: (1) role of basic muscle pain sensitivity and psychological factors in the prediction of movement-evoked pain (MEP) following delayed onset muscle soreness (DOMS), and (2) association of MEP with changes in systemic muscle pain sensitivity following DOMS induction. Methods: Fifty-one participants were assigned to e...
Article
Full-text available
Creative thinking represents a major evolutionary mechanism that greatly contributed to the rapid advancement of the human species. The ability to produce novel and useful ideas, or original thinking, is thought to correlate well with unexpected, synchronous activation of several large-scale, dispersed cortical networks, such as the default network...
Article
Brains that fire together wire together: interbrain plasticity underlies interaction-based learning Even though social interactions are significant determinants of learning, the field of neuroplasticity doesn’t take this into account. Instead, it is deeply rooted in probing changes occurring in synapses, brain structures, and networks within an ind...
Article
Full-text available
Civilian casualties occur during military attacks. Such ‘collateral damage’ is prohibited by international laws but increases with substantial consequences when intergroup conflict escalates. Here, we investigate cognitive and neural bases of decision-making processes resulting in civilian harm, using a task that simulates punishment decision-makin...
Article
Comforting touch involves contact distress-alleviating behaviors of an observer towards the suffering of a target. A growing number of studies have investigated the effects of touch on pain attenuation, focusing on the (toucher), the target (comforted) or both. Here we synthesize findings of brain mechanisms underlying comforting touch in the targe...
Article
The aim was to investigate the correlation between ADHD symptom severity and impairments in "theory of mind" (ToM) and empathy, and the improvement in these functions following the administration of methylphenidate (MPH). Fifty children aged 6-12 years with ADHD participated in the study. Symptom severity was assessed using the Swanson, Nolan and P...
Chapter
Despite much research on the neural underpinnings of empathy, little research in humans has directly explored the contribution of empathy to interpersonal distress regulation in the suffering target. A growing body of work now investigates interpersonal emotion regulation—how an individual influences and affects the emotions of another person. Here...
Article
Creativity is a multifaceted construct, yet traditionally measured as divergent thinking (DT) with originality as its main focus. As originality tends to be discouraged in East Asian cultures, this measurement discrepancy is especially problematic in cross‐cultural studies. Given cultural variations in the centrality of context, in the current stud...
Preprint
Full-text available
Loneliness is a painful condition associated with increased risk for premature mortality. The formation of new, positive social relationships can alleviate feelings of loneliness, but requires rapid trustworthiness decisions during initial encounters and it is still unclear how loneliness hinders interpersonal trust. Here, we use a multimodal appro...
Article
Objective: Oxytocin (OT) synchrony has been suggested as a key mechanism by which bonds are formed and strengthened in various species, including those between mother and infant and between romantic partners. It is unknown whether such biological synchrony also plays a role in psychotherapy efficacy, where it may underlie the adverse effect of soc...
Preprint
Full-text available
Civilian casualties occur during military attacks. Such collateral damage is prohibited by international laws but increases with substantial consequences when intergroup conflict escalates. We investigate cognitive and neural bases of collateral damage by integrating brain imaging and statistical modeling of punishment decision-making during interg...
Article
Full-text available
Emotion regulation plays a central role in empathy. Only by successfully regulating our own emotions can we reliably use them in order to interpret the content and valence of others' emotions correctly. In an fMRI-based experiment, we show that regulating one's emotion via reappraisal modulated biased emotional intensity ratings following an empath...
Article
Being part of a group is a crucial factor in human social interaction. In the current study we explored whether group membership affects reflexive automatic cognitive functioning, and specifically the social inhibition of return effect (SIOR; Welsh et al., 2005). SIOR is characterized by slower reaction times (RTs) to a location already searched by...
Article
The therapeutic alliance is one of the most consistent predictors of therapeutic change, including symptom reduction and improvement in wellbeing and quality of life, across a variety of mental health interventions. Yet, little is known about its biological mechanisms. Oxytocin (OT) has been suggested as a biological mechanism by which bonds are fo...
Article
Oxytocin (OT) has been implicated in various aspects of social behaviors. During the past decades there has been a surge of interest in the therapeutic potential of OT in psychiatric disorders, especially those characterized by social deficits, which the available therapeutic agents, cannot fully target. This systematic review and meta-analysis exa...
Article
Cognitive processes are traditionally studied in individual settings, while the possible effect of the social context is ignored. The present study focuses on the social inhibition of return effect (SIOR; Welsh et al., 2005). According to it, observation of another person's action at a specific location initiates an inhibitory process in the observ...
Article
The current study aimed to explore the possible effect of stimulants on oxytocin (OT), a neuropeptide which regulates social behavior, as a mediator of the pro-social effect of methylphenidate (MPH) in children with attention deficit hyperactivity disorder (ADHD) compared to healthy controls (HCs). Utilizing a double-blind placebo-controlled design...
Poster
The 8th international meeting of the Integrated Brain and Behavior Research Center at the university of Haifa
Preprint
Over the last two decades, research has devoted increasing attention to the examination of empathy. Yet research examining empathic accuracy, defined as how well we judge the emotional intensity felt by another, has grown more modestly. This asymmetry may be due to the complexity of paradigms used to study empathic accuracy, as well as to the fact...
Article
Full-text available
Background Autism is a highly varied and heritable neurodevelopmental condition, and common variants explain approximately 50% of the genetic variance of autism. One of the genes implicated in autism is the oxytocin receptor (OXTR). The current study combined genetic and brain imaging (fMRI) data to examine the moderating effect of genotype on the...
Article
When we clap our hands in synchrony, feel the sadness of a friend, or match our attitudes to peer norms, we align our behavior with others. We propose here a model that views synchronized movement, emotional contagion, and social conformity as interrelated processes that rely on shared neural networks. Building on the predictive coding framework, w...
Article
Socially anxious individuals show increased sensitivity toward social threat signals, including cues of dominance. This sensitivity may account for the hypervigilance and gaze avoidance commonly reported in individuals with social anxiety. This study examines visual scanning behavior in response to androstadienone (androsta-4,16,-dien-3-one), a put...
Article
The aim of the study was to explore cognitive and affective dimensions of ToM using the computerized Yoni task in participants with amnestic Mild Cognitive Impairment (aMCI=16), early stage of Parkinson’s Disease (PD=14), and healthy controls (HC=18) Results demonstrated that the Yoni task was effective in discriminating between groups in 1th order...
Data
List of the model predictors and corresponding number of levels of each predictor. (DOCX)
Data
Face and body features predicting the highest and lowest scores for each emotion tested. The analysis was conducted using package multcomp in R. (DOCX)
Article
Full-text available
Emotions are signaled by complex arrays of face and body actions. The main point of contention in contemporary treatments is whether these arrays are discrete, holistic constellations reflecting emotion categories, or whether they are compositional—comprised of smaller components, each of which contributes some aspect of emotion to the complex whol...
Data
p values of the lmer model. The p values were calculated by likelihood ratio tests, comparing the full lmer model against the model without the effect. Tests were conducted using the function anova in package lmer in R. (DOCX)
Article
Full-text available
Despite the automaticity of affective sharing, many studies have documented the role of top-down effects and such as social categorization on people's empathic responses. An important question, largely ignored in previous research, concerns empathy to ingroup and outgroup members' pain in the contexts of ongoing intergroup conflict. In the present...
Article
Although evidence points to the existence of cultural differences in creativity, the mechanisms that underlie these differences are largely unknown. The twofold model of creativity posits two recursive stages: a generation phase and an evaluation phase. Considering that recent studies suggest that the left inferior frontal gyrus) L-IFG(may inhibit...
Article
Full-text available
The modulatory role of the primary motor cortex (M1), reflected by an inhibitory effect of M1-stimulation on clinical pain, motivated us to deepen our understanding of M1’s role in pain modulation. We used Transcranial Magnetic Stimulation (TMS)-induced virtual lesion (VL) to interrupt with M1 activity during noxious heat pain. We hypothesized that...
Article
Received: October 20, 2017 Accepted: January 25, 2018 Published online: March 06, 2018 Issue release date: March 2018
Article
Full-text available
A growing body of evidence suggests that humans can communicate socially relevant information, such as aggression, dominance and readiness for competition, through chemosensory signals. Androstadienone (androsta-4,16,-dien-3-one), a testosterone-derived compound found in men's axillary sweat, is a main candidate for a human pheromone that may conve...
Article
Full-text available
Previous studies suggest that women’s body odor is perceived as more attractive during ovulation and that exposure to women’s chemical signals of high fertility leads to increased mating motivation. Given that pair-bonded men react differently than single men to unfamiliar women, we investigated whether women’s chemical signals of fertility influen...
Article
Empathy represents a fundamental ability that allows for the creation and cultivation of social bonds. As part of the empathic process, individuals use their own emotional state to interpret the content and intensity of other people’s emotions. Therefore, the current study was designed to test two hypotheses: (1) empathy for the pain of another wil...
Article
Full-text available
Despite the automaticity of affective sharing, many studies have documented the role of top-down effects and such as social categorization on people's empathic responses. An important question, largely ignored in previous research, concerns empathy to ingroup and outgroup members' pain in the contexts of ongoing intergroup conflict. In the present...
Article
The primary motor cortex (M1) is a known target for brain stimulation aimed at pain alleviation in chronic pain patients, yet the mechanisms through which analgesia occurs, and the exact pain-motor interrelations are not fully understood. We used noxious contact heat evoked potentials (CHEPs) and cortical source analysis to further explore the rele...
Article
Background Autism is a highly heritable condition, and common variants explain approximately 50% of the genetic variance of autism. Individuals with autism typically have difficulties with social interactions, which may be due to altered social cognition. Variants in the Oxytocin Receptor (OXTR) have been implicated in both autism and social cognit...
Article
Full-text available
Behavioral studies found greater pain sensitivity in females that vanishes fully or partially when controlling for the emotional state. Furthermore, pain-related brain activation hints at the role of limbic structures in sex differences in pain processing. We aimed to investigate the role of pain-related limbic structures in mediating the relation...
Article
Full-text available
Studies indicate a strong relationship between empathy and language skills, but the relationship between reading and empathy remains elusive, although a shared neural substrate (the temporoparietal junction; TPJ) has been implicated in both reading and empathy. Motivated by these observations, the purpose of the current study was to examine empathi...

Citations

... The next step would be to keep on the sensitivity of tasks performed during surgery and to tailor their complexity to more integrated functions and behaviors which constitute the essence of human being, even though still neglected by neurosurgeons and neurooncologists, including in terms of personality (18) and creativity (63). To this end, in addition to the peri-operative noninvasive functional neuroimaging, DES mapping represents a unique opportunity to decipher not only function-specific networks but also the cross-talk between neural circuits, enabling to improve the elaboration/selection of more ecological tasks and their optimal administration (order, sequence, combination, timing) throughout the resection in agreement to patients' expectations and according to their vision of life. ...
... Touch with the intention to care for another, such as in a clinical environment, provides better relief from physical and emotional distress than self-care by decreasing the activation of pain-related regions, particularly the dorsal Anterior Cingulate Cortex (ACC) and the Anterior Insular Cortex (AIC) (Shamay-Tsoory and Eisenberger, 2021). The insula is a crucial region in pain processing, and developing evidence indicates that the insula encodes the magnitude of an unexpected outcome -unsigned prediction errors (Horing and Büchel, 2022). ...
... Ten studies [46,47,[58][59][60][61][62][65][66][67] assessing the effects of MPH (either immediate-release or long-acting formulations) on empathy and ToM in young patients with ADHD were finally identified. One study [58] also assessed the effects of atomoxetine (ATX) treatment, while another one [65] compared unimodal (medication only) versus multimodal (medication plus cognitive behavioral therapy). ...
... Creativity is a multifaceted construct articulated differently and traditionally measured as creative thinking (Ivancovsky et al., 2021;Park et al., 2021). Many theories have been developed, focusing on different aspects of it (Sternberg and Karami, 2022). ...
... Yet, some theories about cognitive processes remain still under-researched. This includes connecting cognitive processes to neurological and physiological responses (for examples, see Han et al., 2021;Hattke et al., 2020)). ...
... For example, poor-quality social relationships (Mullins and Dugan, 1990;Hawkley et al., 2008) and conflict in current marital or family relationships (Jones D. C., 1992;Burke et al., 2012) are risk factors that predict feelings of loneliness and isolation (Hawkley et al., 2008). As a result, loneliness is also related to stronger expectations of, and motivation to avoid, negative social outcomes and weaker expectations of positive social outcomes (Gable, 2006) as well as increased comorbidity with symptoms of social anxiety (Lieberz et al., 2021a). Because of this fear of social rejection, loneliness is also associated with increased hypervigilance to social threats and, therefore, lonely individuals are more likely to be less trusting and more hostile in uncomfortable social situations (Duck et al., 1994;Anderson and Martin, 1995;Cacioppo and Patrick, 2008;Lieberz et al., 2021b). ...
... Regarding depressive disorders, one study was able to demonstrate that the lower the patients' oxytocin, the lower their degree of change in depression over the course of a cognitive behavioural analysis system of therapy (CBASP) program [64]. Another study in patients with depressive disorders showed that interpersonal difficulties at baseline were associated with lower oxytocin synchrony between patients and therapists during psychodynamic psychotherapy, which, in turn, predicted a less pronounced reduction in depressive symptoms over the course of treatment [65]. Regarding anxiety disorders, one study in patients with social anxiety disorder tested intranasal oxytocin as an adjunct to exposure therapy [66]. ...
... The study sample was drawn from children who were diagnosed with ASD at the National Autism Research Center of Israel (NARCI) [36,37], which is located in Be'er Sheva, the capital city of the southern region, between January 2015 and December 2019. The sample included all the children whose parents consented to provide DNA samples for themselves and the children. ...
... Another study identified AG responses during reappraisal of painful (vs. non-painful) scenarios that downregulate empathy for pain in healthy adults (81). In adults with fibromyalgia, music-induced analgesia was associated with reduced AG rsFC to several nodes of the default mode network (DMN) (78). ...
... One study in patients with major depressive disorder undergoing psychodynamic treatment showed that the higher the extent of within-session conflict and confrontational ruptures with the therapist, the greater the patients' increase in oxytocin [69]. Another study in patients with major depressive disorder undergoing the same treatment showed that reduced proximity seeking toward the therapist was associated with greater increases in oxytocin [70]. These studies suggest that, at least in depressive disorders, modulation of the patients' oxytocin levels is one mechanism by which the therapeutic alliance may cause change. ...