Simona Roxana Georgescu's research while affiliated with Carol Davila University of Medicine and Pharmacy and other places

Publications (8)

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There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia...
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Inflammatory skin diseases occur after the onset of abnormal immune cell responses and the activation of various immune signaling pathways in the skin [...]
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Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). In 2014, Erel and Neseliog...
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Platelet-rich plasma (PRP) represents a novel therapy tested and is used more and more frequently in dermatology and cosmetic surgery for a variety of conditions, including androgenic alopecia (AGA), a common condition with a complex pathogenesis involving genetic factors, hormonal status and inflammation. We performed an extensive literature searc...
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Since ancient times, people have tattooed their skin for various reasons. In the past, tattoos were associated with low social status; nowadays, tattoos are very popular and are considered a form of art. However, tattoos are associated with various clinical problems, including immune reactions, inflammatory disorders, infections, and even skin canc...
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Hepatocellular carcinoma (HCC) is the most common primary liver cancer and affects about 8% of cirrhotic patients, with a recurrence rate of over 50%. There are numerous therapies available for the treatment of HCC, depending on cancer staging and condition of the patient. The complexity of the treatment is also justified by the unique pathogenesis...
Article
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Cutaneous squamous cell carcinoma (cSCC), a malignant proliferation of the cutaneous epithelium, is the second most common skin cancer after basal cell carcinoma (BCC). Unlike BCC, cSCC exhibits a greater aggressiveness and the ability to metastasize to any organ in the body. Chronic inflammation and immunosuppression are important processes linked...
Article
Molecular pathology of benign prostatic hyperplasia is multifactorial and involves endocrine, biochemical, immunological interactions. The mechanisms involved in the onset and progression of benign prostatic hyperplasia are: infections, 50 years of age, hormones and neurotransmitters imbalances, inflammation, oxidative stress. The potential role of...

Citations

... ROS modulate important processes underlying the pathogenesis of urticaria such as mast cell degranulation, endothelial cell function and vascular permeability. Moreover, mast cell activation is influenced by ROS-dependent activation of protein kinase C [64]. ...
... P = 0.016). [30] Most studies that recruited both men and women indicate that PRP treatment may be more effective in male AGA. Several randomized controlled trials have demonstrated synergistic effects of the combination of PRP with oral finasteride and topical minoxidil. ...
... Regarding actinic keratoses, only the serum TSA levels were significantly higher. They suggest that the serum ST6GalI/NEU3 level may be useful in differentiating patients with cSCC from noncancer patients [14]. Dudau et al. showed that sea buckthorn seed oil, a compound rich in long-chain fatty acids known to have beneficial effects on the skin, may promote the proliferation of normal and dysplastic keratinocytes under basal conditions and when they are exposed to UVA irradiation. ...