Sijing An's research while affiliated with Institute of Basic Medical Sciences and other places
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Publications (3)
A bstract
Rapidly developing single-cell multi-omics sequencing technologies generate increasingly large bodies of multimodal data. Integrating multimodal data from different sequencing technologies, i.e . mosaic data, permits larger-scale investigation with more modalities and can help to better reveal cellular heterogeneity. However, mosaic integ...
Intestinal bacteria strains play crucial roles in maintaining host health. Researchers have increasingly recognized the importance of strain-level analysis in metagenomic studies. Many analysis tools and several cutting-edge sequencing techniques like single cell sequencing have been proposed to decipher strains in metagenomes. However, strain-leve...
Liver cirrhosis (LC) has been associated with gut microbes. However, the strain diversity of species and its association with LC have received little attention. Here, we constructed a computational framework to study the strain heterogeneity in the gut microbiome of patients with LC. Only Faecalibacterium prausnitzii shows different single-nucleoti...
Citations
... Most sequencing projects prioritized sample size over high-coverage, perhaps due to the observation that MAG yield per gigabases sequenced per sample peaks at the lower end of library sizes ( Figure S1-2). Some of the most deeply sequenced [23,24] or unusual [25] datasets were analyzed unassembled. The endgame of the reference MAG accumulation process is unclear. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/859592066076673-1581954127227_Q64/Zhen-He-3.jpg)
