Sigrid Steller's research while affiliated with Max Planck Institute for Molecular Genetics and other places
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Publications (6)
Neisseria meningitidis is the most common cause of meningitis and causes epidemic outbreaks. One trait of N. meningitidis, which is associated with most of the currently recognized virulence determinants, is the presence of phase-variable genes that are suspected to enhance its ability to cause an invasive disease. To detect the immune responses to...
In this paper, the initiation reactions in surfactin biosynthesis by Bacillus subtilis OKB 105 were investigated. Evidence for a specific role of the SrfD protein, the external thioesterase enzyme in surfactin biosynthesis, was obtained for the first time. The action of SrfD was investigated both with the native, but only partially purified, enzyme...
The purification of the multienzyme system producing the lipodecapeptide fengycin in Bacillus subtilis b213 was investigated. By gel filtration of a cell free extract of this organism three enzyme fractions were obtained from which five multifunctional components of fengycin synthetase were separated by high resolution anion-exchange FPLC procedure...
Bacillus subtilis strains produce a broad spectrum of lipopeptides that are potent biosurfactants and have specific antimicrobial and antiviral activities. The cyclic lipodecapeptide fengycin is one such compound. Although the fengycin biosynthetic genes in B. subtilis 168 (pps genes) and F29-3 (fen genes) have been well characterized, only limited...
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Citations
... Nowadays, a faster and more powerful technology to perform epitope mapping is represented by protein microarrays, which allow analysing simultaneously short and long peptides that are representative of all immunogenic regions of an antigen, including both linear and conformational epitopes, with the further advantage of using only minimal volumes of biological samples. Proteomic microarrays generated by spotting full-length antigens are largely used to profile responses to bacterial infections 25,26 or following vaccination [27][28][29] or as diagnostic tool 30 . ...
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... Genes encoding for lipopeptides, as other NRP antimicrobial molecules, are also identified in B. subtilis PTA-271 [41,156,158,160,163]. Among their products, the previously cited elicitors of plant defenses: (1) fengycin is also a powerful antifungal substance described as particularly active against filamentous fungi [157]. It interferes with the integrity of biological membranes until their complete disruption at high concentrations [158]. ...
... Figure 2A shows the MALDI-TOF mass spectrum of a surface extract of this organism using TSA as cultivation medium. It produces the surfactin and fengycin lipopeptide families which are formed nonribosomally at multimodular enzyme complexes (Menkhaus et al., 1993;Steller et al., 1998). Prominent species were found for surfactin at m/z = 1058.8 ...
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... Antibiotics produced by the Bacillus species are more effective against Gram-positive bacteria; however, the production of large spectrum and anti-fungal antibiotics that are effective against Gram-negative bacteria is relatively less (Morikawa et al., 1992;Perez et al., 1993;Eltem and Ucar,1998). The Bacillus species have a wide range of antimicrobial activities since they are used as antifungal agents (Milner et al., 1995), antiviral agents (Steller et al., 1999) anti-ameobocytic agents (Galvez et al., 1994) and anti-mycoplasma agents (Peypoux et al., 1999). This study therefore aimed at investigating the antimicrobial activity of Bacillus species isolated from the southern part of Nigerian soil against some pathogens and other test bacteria. ...
... Finally, the surfactin synthetase assembly line can be initiated in presence of a CoA-activated FA (Steller et al., 2004). Fatty acids are converted into their corresponding acyl-CoA derivative by fatty acyl CoA ligases (FACS). ...
