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![Methods for the Synthesis of 5H‐thiazolo[3,2‐a]pyrimidine](https://www.researchgate.net/publication/333654359/figure/fig1/AS:11431281245050259@1716053451189/Methods-for-the-Synthesis-of-5H-thiazolo3-2-apyrimidine_Q320.jpg)
![A plausible reaction mechanism for the Synthesis of 5H‐thiazolo[3,2‐a]pyrimidine Derivatives](https://www.researchgate.net/publication/333654359/figure/fig2/AS:11431281245050260@1716053451424/A-plausible-reaction-mechanism-for-the-Synthesis-of-5H-thiazolo3-2-apyrimidine_Q320.jpg)
June 2019
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53 Reads
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6 Citations
A new strategy for the synthesis of 5H‐thiazolo[3,2‐a]pyrimidines from KI/K2S2O8 mediated C−S and C−N bond tandem cyclization reaction of enaminones with 3,4‐dihydropyrimidin‐2(1H)‐thiones has been developed. This method features inexpensive catalyst, base free and transition‐metal free with simple procedure, affording the desired products in moderate to excellent yields.
April 2019
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21 Reads
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18 Citations
New Journal of Chemistry
A novel and green method for the synthesis of 5-amino-1,2,4-thiadiazoles has been developed by the reaction of isothiocyanates with amidines. This protocol which is free of metal, catalyst and iodine involves O 2 oxidative S-N bond formation for the synthesis of various 5-amino-1,2,4-thiadiazole derivatives with excellent to good yields. High regioselectivity, mild reaction conditions, broad substrate scope and good functional group tolerance are the highlights of the report. © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2019.
... In this metalfree and gram-scale synthetic strategy, substituted amidines 18 and substituted isothiocyanates 19 were treated for the construction of the S-N bond via I2 mediated oxidative coupling to produce 5-amino-1,2,4-thiadiazole derivatives 20 in the presence of TMEDA (N,N,N′,N′-tetramethyl ethylene diamine), air (oxidant) and acetonitrile as the solvent. In this synthetic pathway, 1,2,4-thiadiazoles were afforded in moderate-to-excellent yields (Scheme 7) [259]. ...
April 2019
New Journal of Chemistry
