ShyamSunder Chatterjee’s research while affiliated with Dr. Willmar Schwabe Pharmaceuticals and other places

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Publications (1)


Effect of withanolide-free Withania somnifera extract on the plasma glucose, insulin and cortisol in male mice
Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice
  • Article
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July 2019

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251 Reads

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25 Citations

AYU (An International Quarterly Journal of Research in Ayurveda)

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ShyamSunder Chatterjee

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Background: The objective of the study is to compare stress resistance-promoting effect of triethylene glycol (TEG) and root extract of Ashwagandha (Withaniasomnifera) i.e. withanolide-free root extract of Withaniasomnifera (WFWS). Materials and methods: Mice groups treated orally with 10 mg/kg TEG or WFWS (3.3, 10, 33.3, or 100 mg/kg) for 12 consecutive days were subjected to foot shock stress-triggered hyperthermia test on the 1st, 5th, 7th and 10th day and to marble-burying test on the following 2 days. Effects of treatment on stress-triggered alteration in body weight, core temperature, blood glucose, insulin and cortisol level were quantified and statistically analyzed. Results: WFWS doses up to 10 mg/kg/day were as effective as TEG in affording protection against stress-triggered alteration in body weight, core temperature and marble-burying behavior. Protection against stress-triggered alteration in blood glucose and insulin level, as well as antidepressants or anxiolytic-like activities in the behavioral test, were observed in the higher two WFWS doses (33.3 and 100 mg/kg) treated groups only. Conclusion: Ashwagandha metabolites other than withanolides contribute to its stress resistance increasing effects. The observations suggest that modulation of physiological functions of gut microbiota may be involved in the mode of action of Withaniasomnifera root extracts.

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Citations (1)


... In addition, while withanolides have been the focus of research into WS's active compounds, a variety of other phytochemical types have been isolated from WS extracts, including alkaloids, flavonoids, steroids, and nitrogen-containing compounds [69]. Pre-clinical studies suggest that non-withanolide compounds may be responsible for some of WS's biological activity [70][71][72][73][74] and therefore, future studies should attempt to identify and quantify both withanolide and non-withanolide compounds in WS and explore potential synergistic effects between these compounds, particularly at biologically relevant concentrations. Finally, animal studies should further explore WS compound levels in biological matrices other than plasma; specifically, quantifying WS compound levels in the brain should be a priority given research suggesting a potential role for WS in neurodegenerative diseases and cognition [75][76][77][78]. ...

Reference:

Quantifying Withanolides in Plasma: Pharmacokinetic Studies and Analytical Methods
Triethylene glycol-like effects of Ashwagandha (Withania somnifera (L.) Dunal) root extract devoid of withanolides in stressed mice

AYU (An International Quarterly Journal of Research in Ayurveda)