January 2025
·
2 Reads
Digestive Endoscopy
This page lists works of an author who doesn't have a ResearchGate profile or hasn't added the works to their profile yet. It is automatically generated from public (personal) data to further our legitimate goal of comprehensive and accurate scientific recordkeeping. If you are this author and want this page removed, please let us know.
January 2025
·
2 Reads
Digestive Endoscopy
December 2024
·
5 Reads
Journal of Clinical Biochemistry and Nutrition
The number of eosinophilic esophagitis (EoE) patients has been rapidly increasing worldwide in recent years, though remains relatively lower in Japan. To determine whether Japanese EoE cases have pathogenic differences, microRNA (miRNA) transcriptome analyses of esophageal biopsy specimens from patients with EoE were performed to identify involved miRNAs and the results were compared with those for cases reported in Western countries. Japanese patients with EoE (n=9) or reflux esophagitis (RE) (n=4) were enrolled, with the latter serving as controls. Biopsies of esophageal mucosal tissue were performed as a part of an upper gastrointestinal endoscopy, followed by comprehensive miRNA expression analysis (2588 target human miRNAs) using microarray technology. The EoE patients were then treated with a proton pomp inhibitor, and miRNA expression in the esophagus was compared before and after treatment. Hierarchical cluster analysis findings showed clear differences in miRNA expression patterns between the EoE and RE patients, with increased expression of 13 and decreased expression of 10 miRNAs noted in the EoE cases. These results were then compared with miRNA expression in esophageal mucosa of EoE patients presented in Western reports and the expression profiles were found to be very similar. In addition, changes in expression profiles of several miRNAs before and after treatment were observed in the present EoE patients. miRNA microarray analysis of Japanese EoE patients demonstrated a significant overlap of miRNA expression in comparison with Western patients, indicating that EoE likely represents the same disease among diverse racial populations and shows a consistent pathogenesis worldwide.
December 2024
·
72 Reads
·
2 Citations
The Lancet
November 2024
·
9 Reads
Internal Medicine
Amiodarone is an antiarrhythmic drug that is widely used for atrial fibrillation and other refractory arrhythmias. Although beneficial, its long-term administration is associated with adverse effects on various organs. One patient presented with amiodarone-induced liver injury, which led to liver failure. Computed tomography revealed a gradual increase in hepatic density over a long period following the initiation of amiodarone. Despite the discontinuation of the drug, the patient developed hepatic encephalopathy and subsequently died. This outcome highlights the drug's extended half-life, which caused persistent end-organ damage even after its withdrawal. Drug titration to the lowest effective dose and careful monitoring of annual liver function tests are important.
July 2024
·
16 Reads
Endoscopy
July 2024
·
14 Reads
Clinical Journal of Gastroenterology
A man in his 30s was referred to our department for evaluation of bile duct stricture and removal of an intrahepatic bile duct stone. Five years before his presentation, he underwent left hepatectomy for a giant hepatic hemangioma. There were no abnormalities in blood biochemical tests. Magnetic resonance cholangiopancreatography showed one 5 mm oval defect in region B6 and two 8 mm semicircular defects in the hilar bile duct. Endoscopic ultrasound revealed a 3.5 mm hypoechoic focal raised lesion in the hilar bile duct. Oral cholangioscopy revealed his two lesions in the hilar bile duct as white papillary elevations with mucus production. The pathological diagnosis of intraductal papillary neoplasm was determined (low-grade dysplasia, type 1, gastric type). After 1 and a half years, no expansion of the bile duct lesion was observed. Initially, it was thought to be a benign stenosis after liver resection, but based on the results of endoscopic ultrasound, we suspected a tumorous lesion, and we were able to make an accurate diagnosis, including histological type, using transoral cholangioscopy.
June 2024
·
7 Reads
Journal of Clinical Biochemistry and Nutrition
Introduction Type 1 diabetes mellitus (T1DM) may be associated with other autoimmune diseases. Celiac disease (CD), another autoimmune disorder that mainly affects the small intestine, is caused by intolerance to gluten ingestion. CD has a higher prevalence in patients with T1DM than in the general population. However, the prevalence of CD in patients with T1DM in Japan is unknown. This study investigated the prevalence of CD in Japanese patients with T1DM. Methods We included 115 patients with T1DM treated at Hyogo Brain and Heart Center from December 2020 to April 2021. A questionnaire survey about dietary habits and abdominal symptoms was administered, and serum anti-tissue transglutaminase (TTG) antibody titers were determined for all participants. A CD (CD-seropositive) diagnosis was based on TTG levels >10 U/ml. Results Fifty-eight patients (50.4%) had some abdominal symptoms (such as constipation, diarrhea, and abdominal pain). The average TTG-IgA antibody titer was 0.75 ± 0.49 U/ml and negative (<10 U/ml) in all patients. Conclusions The prevalence of CD among patients with T1DM at our hospital was 0%. Thus, the prevalence of CD in Japan is low compared to that in other countries, even among patients with T1DM, who are considered to have high comorbidity rates.
June 2024
·
4 Reads
Pathology International
Reports of Helicobacter pylori ( Hp )‐naïve gastric neoplasm (HpNGN) cases have been rapidly increasing due to the recent increase in the Hp ‐naïve population in Japan. Most HpNGNs exhibit the gastric immunophenotype and a low malignant potential regardless of histological type. Especially, foveolar‐type gastric adenoma (FGA) and intestinal‐type gastric dysplasia (IGD) rarely progress to invasive carcinoma. FGA is a foveolar epithelial neoplasm that occurs in the fundic gland (oxyntic gland) mucosa and is classified as the flat type or raspberry type (FGA‐RA). The flat type is a large, whitish flatly elevated lesion while FGA‐RA is a small reddish polyp. Genomically, the flat type is characterized by APC and KRAS gene mutations and FGA‐RA by a common single nucleotide variant in the KLF4 gene. This KLF4 single‐nucleotide variant reportedly induces gastric foveolar epithelial tumorigenesis and activates both cell proliferation and apoptosis, leading to its slow‐growing nature. IGD consists of an intestinalized epithelial dysplasia that develops in the pyloric gland mucosa, characterized as a superficial depressed lesion surrounded by raised mucosa showing a gastritis‐like appearance. Immunohistochemically, it exhibits an intestinal or gastrointestinal phenotype and, frequently, p53 overexpression. Thus, IGD shows unique characteristics in HpNGNs and a potential multistep tumorigenic process.
May 2024
·
5 Reads
Gastroenterology
April 2024
·
21 Reads
Internal Medicine
Objective The presence of a short white hair-like appearance in the lower esophagus has recently been noted during esophagogastroduodenoscopy (EGD) at our institution. Histological findings showed that this formation was a spiked protrusion of the esophageal papilla. The results regarding the prevalence of such lesions in individuals who underwent EGD examinations as part of medical checkup procedures are herein presented. Methods The EGD results of 14,338 individuals (9,225 males, 5,113 females; mean age 54.0±9.8 years) were examined. The findings related to the presence of multiple lesions with a short white hair-like appearance in the lower esophagus of patients with reflux esophagitis, esophageal squamous papilloma, or gastric mucosal atrophy (GMA), as well as the hiatal hernia width, were investigated. Results Endoscopic findings indicating short white hair-like appendages in the lower esophagus were noted in 167 patients, with a prevalence rate of 1.2%. A female sex, younger age, lower body mass index, lower percentages of habitual smoking and drinking, and the presence of esophageal squamous papilloma were characteristic features of cases with such findings. In addition, a significantly lower prevalence of reflux esophagitis and a smaller diaphragmatic hiatus size were observed. A multiple logistic regression analysis indicated that a female sex, absence of reflux esophagitis, presence of esophageal squamous papilloma, and a smaller diaphragmatic hiatus were factors significantly related to the presence of these short white hair-like appendages. An analysis of circumferential localization revealed the main location to be the left-posterior wall. Conclusion This study is the first to report the prevalence of multiple short white hair-like appendages in the lower esophagus. The occurrence of such lesions is inversely associated with the presence of reflux esophagitis.
... In the maintenance study, patients who had responded during the induction study were randomized in a 1:1:1 ratio to receive guselkumab at 200 mg SC every 4 weeks, guselkumab at 100 mg SC every 8 weeks, or a placebo for a total of 44 weeks. At week 44, clinical remission was achieved in 50%, 45%, and 19% of the participants treated with guselkumab at 200 mg every 4 weeks, at 100 mg every 8 weeks, and the placebo, respectively [66]. ...
December 2024
The Lancet
... Endoscopic treatment of superficial esophageal squamous cell carcinoma (ESCC) in the presence of such an anastomotic stricture is challenging and requires ingenuity of devices and scopes [2]. Endoscopic submucosal dissection (ESD) with water or gel immersion helps in difficultto-treat situations [3,4], and the utility of a small-caliber tapered conical hood during ESD is established [5]. Herein, we describe underwater ESD with a conical hood and gel immersion, which was performed successfully for superficial ESCC with post-TPL anastomotic stricture (▶ Video 1). ...
March 2024
Endoscopy
... Cirurgias, como a duodenojejunostomia, apresentam altas taxas de sucesso, com alívio duradouro e melhora na qualidade de vida (Suto et al., 2024). Dada a raridade da SAMS, o diagnóstico diferencial em pacientes com distúrbios alimentares e perda de peso acentuada é essencial, reforçando a importância do reconhecimento precoce de sinais críticos para prevenir complicações fatais (Hasegawa et al., 2024). ...
February 2024
... Due to its simple stool-processing method and shorter turnaround time, Buhlmann turbidometry is routinely ordered to detect inflammation in the GI tract. Recent findings have validated the performance of the fCAL-turbo assay, showing a strong correlation with endoscopic activity in IBD patients [30]. While analyzing patient data, we observed that the AFCAL assay was performed multiple times within a year for some patients, often at short time intervals, without the use of invasive procedures like colonoscopy and endoscopy. ...
January 2024
... Despite these limitations, the authors precisely analyzed 54 cases of HPNGCs, which is comparable to the number of 63 HPNGCs in a recent multicenter study. 4 In that multicenter study, HPNGCs were less invasive (98.4% detected in early stage), smaller (median size of 4.0 mm), and more frequently located in the proximal stomach than H. pylori-related gastric cancers. ...
October 2023
Journal of Gastroenterology
... More recently, tofacitinib has been used as a sequential therapy in ASUC predominantly after failure of one or more biologics, or as first-line rescue in biologic-experienced patients presenting with ASUC. 10,42,[44][45][46][47][48][58][59][60][61][62][63][64][65][66][67][68][69] These studies are summarized in Table 1. Tofacitinib works by inhibiting intracellular JAK (predominantly JAK 1 and 3, and to a lesser extent JAK 2) and subsequent phosphorylation of signal transducers and activators of transcription, causing decreased production of multiple cytokines. ...
October 2023
Journal of Gastroenterology
... Patients were randomized to receive 200 mg or 400 mg of guselkumab, or a placebo. At the end of the 12-week induction phase, clinical response rates were significantly higher in the guselkumab groups compared to the placebo (200 mg: 61.4%; 400 mg: 60.7%; placebo: 27.6%) [65]. ...
September 2023
Gastroenterology
... Foveolar-type adenocarcinoma of the stomach is a rare variant of gastric cancer characterized by a tumor with a well-differentiated (WD) glandular architecture and low-grade nuclear atypia that mimics regenerative gastric foveolar (surface) epithelial cells [1][2][3]. According to Japanese diagnostic criteria, sporadic gastric foveolar-type neoplasms can be classified into 2 subtypes: conventional and raspberry-like [2,[4][5][6][7]. The conventional type is markedly rare and typically observed as a whitish, flat-elevated lesion, whereas the raspberry-like type is a recently recognized disease entity characterized by a small reddish protrusion with a fine granular surface. ...
August 2023
Gastric Cancer
... Individuals who have undergone rapid weight loss are particularly susceptible [2]. This condition is often multifactorial, with predisposing factors including significant weight loss, lumbar spine deformities, and anatomical variations such as a short ligament of Treitz and low insertion of the SMA on the aorta [2,5]. Here, we present a case of aorto-mesenteric clamp syndrome in an infant, examining the etiopathogenic mechanisms, diagnostic approaches, and therapeutic options. ...
May 2023
World Journal of Clinical Cases
... There are numerous case reports in literature about the link between PSVD, predominantly described as NRH, and AZA/6-MP therapy in IBD patients ( Table 1 ). In most of the documented cases, the occurrence of PSVD was associated with AZA treatment [24][25][26][27][28][29][30][31][32][33][34][35][36][37] . However, only a small number of case reports have so far mentioned PSVD associated with 6-MP therapy, which may be because of greater use of AZA than 6-MP in this context [38][39][40] . ...
April 2023
Journal of Crohn s and Colitis