Shubiao Zhang’s research while affiliated with Dalian Minzu University and other places

... The kinetics of the adsorption of MG by the MMOF hydrogel was studied by adopting a quasi-first-order kinetic model [20][21][22] and a quasi-second-order kinetic mode [23][24][25][26] ( Figure 4). The relevant parameters are listed in Tables 1 and 2. The relationships shown in Equations (1)-(3) represent the quasi-first-order kinetic model, the quasi-second-order kinetic model, and the parameters of the intra-particle diffusion model. ...

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Metal–Organic Framework (MOF)-Embedded Magnetic Polysaccharide Hydrogel Beads as Efficient Adsorbents for Malachite Green Removal

... The latter might be attributed to the destabilization of the plasma membrane by DMPCbased HDL NPs at high concentrations, potentially through pore formation [73,74]. The structure of the head group in CLs substantially affects their toxicity [75,76]. For the novel CLs incorporated into HDL NPs, we observed several cytotoxicity dependencies influenced by the oligoamine head group structure. ...

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High-density lipoprotein-like nanoparticles with cationic cholesterol derivatives for siRNA delivery

... SphK1 is more prominently implicated in cancer progression and chemoresistance [20], while SphK2, although involved in cell death and survival pathways, appears to function differently depending on the cellular context. Due to its strong association with tumor progression, selective targeting of SphK1 is emerging as a promising strategy in cancer therapy [19], and, recently, inhibition of SphK1 using selective agents, such as PF-543, has demonstrated promising cytotoxic effects in preclinical models by disrupting S1P signaling and sensitizing cancer cells to conventional therapies [19,21,22]. ...

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FAM46C Expression Sensitizes Multiple Myeloma Cells to PF-543-Induced Cytotoxicity

... Recently, carbon dots (CDs), as a rising star of carbon-based nanomaterials, have displayed outstanding merits in terms of dispersion stability, ease of preparation, low cost, and eco-friendliness [21][22][23][24][25]. In general, CDs are defined as small carbon nanoparticles less than 10 nm in size and fluorescence as instinct performance [26][27][28]. ...

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Effects of a novel carbon nanomaterial on hydration, mechanics, and chloride binding of cement composites

... Consequently, the selected descriptors should be endpointoriented to ensure the relevance and predictive accuracy of the developed models. In the context of NPs and AdMa, genotoxicity and inflammatory effects are primarily driven by over production of ROS, which in turn leads to oxidative stress -a key mechanism of toxicity [56,[70][71][72][73][74][75][76][77][78]. In addition, the dissolution and subsequent release of toxic metals (including transition and heavy metals) play a critical role, influencing both the biological response(s) and the recovery process through clearance mechanisms [16,[79][80][81]. ...

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Dynamic QSAR modeling for predicting in vivo genotoxicity and inflammation induced by nanoparticles and advanced materials: a time-dose-property/response approach

... Another study realized by Yang et al. illustrated the efficiency of PTX and gemcitabine enriched-hyaluronic acid and 6-(2-nitroimidazole)-hexylamine polymers to accumulate at tumor sites, enter into tumor cells via endocytosis, and initiate MDA-MB-231 cell death. Similar to the previous results, the researchers observed that free drugs exhibited toxic side effects, while their encapsulation stimulated the targeted anti-tumor effect, in a time-dependent manner [83]. ...

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Implantable Polymer Scaffolds Loaded with Paclitaxel–Cyclodextrin Complexes for Post-Breast Cancer Tissue Reconstruction

... Moreover, owing to the extreme toxicity of N 2 H 4 ·H 2 O, the utilization of hollow CuS in the biological domain is severely limited. Polydopamine (PDA) is gaining popularity in the field of biomedicine because of its excellent biocompatibility, adhesion, and biodegradability [27,28]. Also, it demonstrates remarkable photothermal conversion ability when exposed to NIR laser and is recognized as one of the promising candidates for photothermal therapeutic agents [29,30]. ...

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Chitosan Hydrogel Equipped With Hollow Copper Sulfide/Polydopamine Nanoparticles for Near‐Infrared/pH Dual‐Responsive Drug Delivery

... Some of the liposomal systems that are on the market are based on phytoconstituents such as resveratrol, quercetin, curcumin, and berberine [150]. Sun et al. demonstrated that the phytochemical quercetin produces pH-sensitive hyaluronic acid-targeted nano-micelles that are effective against breast cancer while lowering the drug's toxicity to healthy tissues [151]. Lastly, it was shown that the formulation of mesoporous silica encapsulating curcumin, a naturally occurring phytochemical with antioxidant qualities, caused apoptosis in MDA-MB-231 cells by inducing ROS generation, stopping the cell cycle, and altering NF-κB and Bax-mediated apoptotic pathways [152]. ...

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Nanotechnology-mediated precision drug delivery strategies for breast cancer treatment

... Multiple delivery systems, such as lentiviral vectors, adeno-associated virus, and exosomes, have been developed to transport mRNA into the body [27]. Among these, lipid nanoparticles (LNPs) are a type of nanoparticle that can encapsulate and protect mRNA molecules from rapid clearance by the body by effectively delivering mRNA into cells [28][29][30]. LNPs are non-viral vectors, which means that they do not insert their DNA into the host genome. LNPs are also biocompatible, have low immunogenicity and cytotoxicity, and can effectively deliver mRNA to a variety of tissues [25,31]. ...

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Effects of Modified Messenger RNA of Adiponectin Delivered by Lipid Nanoparticles on Adipogenesis and Bone Metabolism In Vitro and In Vivo

... Moreover, they have gained significant attention for their diverse beneficial properties including antimicrobial, antioxidant, antitumor, anti-inflammatory, and insecticidal activities [5,[8][9][10][11]. These esters are both tasteless and odorless, making them suitable for various applications in food [12][13][14], cosmetics [5], and pharmaceuticals [3][4][5]15,16]. SEs can be synthesized from cost-effective and renewable sources (sucrose and naturally occurring fatty acid sources) [2,5,17,18], and can also be directly derived from natural products such as fruits, leaves, and other plant parts [8]. ...

Reference:

Temperature response of sucrose palmitate solutions: Role of ratio between monoesters and diesters