Shu Wu’s scientific contributions

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Publications (3)


Fig. 3 Prevalence of bacterial pathogens over the 13-year period. a Shows the prevalence of isolates during the study period. b Describes the distribution of patients alongside positive cultures throughout the study period. c Demonstrate the culture positivity rates in different years of the investigation period
Fig. 4 Prevalence of bacterial isolates per gender and age group. Isolated bacteria were distributed according to sex (a) and age group (b) of the patients
Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi
  • Article
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January 2021

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20 Citations

BMC Infectious Diseases

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Background Bacterial infections are a significant cause of sickness and death in sub-Saharan Africa. This study aimed at establishing the prevalence, distribution and antimicrobial susceptibility pattern of major bacterial isolates from patients accessing medical care at a tertiary hospital in Malawi. Methods We retrospectively reviewed bacteria culture and antimicrobial susceptibility records for 4617 patients from 2002 to 2014 at Mzuzu Central Hospital (MCH). No inclusion and exclusion criteria were followed. Data was analysed using excel (Microsoft office, USA) and GraphPad prism 7 software programs. Results The most prevalent isolates were S. aureus (34.7%, n = 783), Klebsiella species (17.4%, n = 393) and Proteus species (11.4%, n = 256). Most microorganisms were isolated from adults (88.3%, n = 3889) and pus was the main source (69.3%, n = 1224). S. pneumoniae was predominantly isolated from cerebrospinal fluid (60.3%, n = 44) largely collected from children (88.2%, n = 64). Overall, most bacteria exhibited high resistance to all regularly used antimicrobials excluding ciprofloxacin. Conclusions Our report demonstrates an increase in bacterial infection burden in sites other than blood stream and subsequent increase in prevalence of antimicrobial resistance for all major isolates. Creating an epidemiological survey unit at MCH will be essential to help inform better treatment and management options for patients with bacterial infections.

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Citations (1)


... [12] A high percentage of these microbial isolates in this study is a cause for concern as they are the potential pathogens causing a variety of infections in both immunocompetent and immunocompromised patients. [13] To categorize the group most vulnerable to microbial infections, all bacterial isolates were grouped according to inpatient and outpatient categories. Among gram-negative isolates, E. coli was most commonly isolated from outpatients in comparison to inpatients. ...

Reference:

Prevalence of Bacterial Pathogens and their Antimicrobial Susceptibility Patterns at a Tertiary Care Hospital in Riyadh
Prevalence, distribution and antimicrobial susceptibility pattern of bacterial isolates from a tertiary Hospital in Malawi

BMC Infectious Diseases