Shobhit Kumar's research while affiliated with Uttar Pradesh Textile Technology Institute and other places

... The protective role of silymarin on diabetic cardiomyopathy is strongly supported by the literature either in cell lines (H9c2 rat embryonic heart cells) or in animal models (diabetic mice at the dose of 100 mg/kg) [127]. Its cardioprotective ability is expressed via the inhibition of myocardial fibrosis and collagen deposition through the counter-regulation of the TGF-β1/Smad signaling pathway [128]. Furthermore, silymarin can be involved in the regulation of Tropomyosin alpha-1 chain (TPM1) and ...

... The permeation of curcumin through everted goat intestine was evaluated in a tablet dissolution apparatus (DS-8000, Lab India analytical Instruments Pvt. Ltd., Maharashtra, India) following the previous procedure with slight modification. 35 The dissolution apparatus type-II (paddle) was used for this study. The dissolution vessels were filled with 900 mL of releasing medium made with PBS containing 0.25% w/v sodium lauryl sulphate (pH 6.8, 37°C). ...

... Furthermore, invivo analgesic activity on rats showed the significantly enhanced anesthetic action of CO-NEG in terms of the latency reaction time and analgesia [125]. In another study, Shram et al. investigated the in-situ-NEG of (AZM) with eugenol intended for intra-pocket drug delivery against the treatment of periodontitis [126]. The developed formulation demonstrated the desired thixotropy behavior for periodontal delivery [126]. ...

... This strategy could particularly benefit patients with IEI and cancer by reducing the chemotherapeutic dose while providing some antimicrobial prophylaxis. Many of these repurposed drugs are antimicrobial agents including salinomycin, monensin, ritonavir, itraconazole, nitazoxanide and ivermectin (6,21,22). For instance, ivermectin synergized with cisplatin to completely inhibit ovarian tumor growth of xenografts in mice compared to 1/3 rd inhibition with cisplatin alone (23). ...

... %transmittance was investigated to assess the droplet size as well as the stability of the formulation because any change in %transmittance leads to a change in droplet size as well as the size distribution of the formulation [21]. The optimized AZL-NE formulation was found to be 93.46 ± 1.13%, which is close to 100, implying that the formulation was transparent, clear, and able to transmit the light. ...

... The majority of drugs used in cancer therapy are natural products or their structural relatives. Combinatorial chemistry and high-throughput screening technologies are used by the pharmaceutical industry to obtain these drugs [146,147]. Thus, more subtle use of nature-derived templates combined with organic chemistry will be much more likely to produce selective analogs [148]. Glioblastoma patients have failed most chemotherapy trials partly due to poor drug penetration through the BBB. ...

... Huntington's disease (HD) is a neurodegenerative disease which is triggered in adulthood, and patients show emotional problems, cannot control their physical movements, have speech disorders and dementia, lose the ability to think, and die within 15-20 years of diagnosis; Huntington's disease is genetically inherited through an autosomal dominant gene located on chromosome 4; it is caused by DNA mutation of generally 37 or more repetition of CAG nucleotides. Proteomic analysis with gel electrophoresis, mass spectroscopy, Western blot, and technology based on chromatogra-phy and X-ray crystallography, where it is shown that there are molecular changes that occur in HD, improves the specific treatment [38]. ...

... Thus, values of PDI can range from 0.00 (for mono-dispersed systems) to 1.00 (for highly dispersed systems). PDI values greater than 0.50 indicate a broader size distribution, whereas those less than 0.50 indicate a narrow size distribution [37,38]. ...

... Blood-brain barrier (BBB) endothelial cells express Lf receptors (LfR). Lf binding to LfR can mediate an Lfmodified drug carrier system through the BBB to increase drug concentration in the brain, and Lf has been widely applied in targeted nanotherapy for nervous system disorders (Huang et al., 2007;Yan et al., 2018;Mittal et al., 2020). Liu et al. (2017) found that Lf-modified daunorubicin and magnolol liposomes were transported via the BBB and promoted drug accumulation in brain tumor tissue. ...

... In the literature, rutin has been suggested to be a powerful antioxidant agent. [35] It prevents increased oxidants such as MDA and the decrease of antioxidants such as GSH in both ischemia-reperfusion injuries [36] and lung injury. [4] In a study in which oxidative stress was created with pulmonary edema, low MDA and high GSH levels were obtained by rutin administration. ...