Shirlee J. Yonkovich's scientific contributions

Publication (1)

The simple pattern of variability in mouse lambda chains suggests that diversity is generated by somatic spontaneous mutation and by sequential selection by antigen of single step mutants.


... In GCs, B cells undergo somatic hypermutation (SHM) of B cell receptor genes, which is followed by positive selection of high-affinity GC B cells. Ultimately, GC B cells differentiate into high-affinity memory B cells (MBCs) and Ab-secreting long-lived plasma cells (LLPCs) (Griffiths et al., 1984;McKean et al., 1984;Weigert et al., 1970). T follicular helper (Tfh) cells are a subset of CD4 + T cells specialized in regulating affinity maturation of B cells in GCs (Crotty, 2019;Vinuesa et al., 2016). ...