Shilpi Khetarpal's research while affiliated with Cleveland Clinic and other places
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Publications (39)
Each year, the dermatology landscape continues to evolve, and the breadth of medical information available to physicians continues to grow at a rapid pace. With the constant pressure of increasing patient volume and healthcare demands, many physicians find themselves with less time to participate in research, education, and staying up to date with...
Background
While numerous studies have demonstrated enhanced hair growth following platelet-rich plasma (PRP) treatments in patients with male and female pattern hair loss, no study has demonstrated its impact on quality of life (QoL) using a validated tool.Objective
This prospective study aimed to assess the psychological impact of PRP treatment f...
Cosmetic dermatology is a key subspecialty of academic dermatology. As such, academic centers are expected to demonstrate excellence in the teaching of cosmetic dermatology skills to trainees, the clinical delivery of cosmetic dermatology services to patients, and the performance of clinical research that advances knowledge and uncovers new therapi...
Cosmetic and laser procedures are increasingly popular among patients and are skills in which dermatologists are regarded as well trained. Most dermatology residents intend to incorporate cosmetic procedures into their practice and prefer to learn such procedures during residency through direct patient care. However, there are notable challenges in...
Radiofrequency microneedling (RFMN) creates tiny skin perforations and delivers thermal energy to underlying tissues to cause dermal coagulation, collagen remodeling, and neoelastogenesis, via a wound-healing response. The skin perforations also improve transcutaneous absorption of topical products and transcutaneous elimination of skin debris. The...
Stem cells have the ability to self-renew and differentiate into other cell types, which forms the foundation for their use in regenerative medicine and cosmetic dermatology. Adipose-derived stem cells have proven particularly attractive in aesthetics given their relative ease of collection and abundance. Stem cells have been employed for the treat...
Background:
Many studies have evaluated radiofrequency microneedling (RFMN) in various dermatologic conditions. However, the efficacy and safety of RFMN, and how it compares with other energy-based devices in a clinician's armamentarium, remains unclear.
Objective:
To review higher-quality evidence supporting RFMN and the dermatologic conditions...
Objective:
We update and expand our 2010 article in this journal, Patient safety in dermatology: A review of the literature [4][DH1].
Methods:
PubMed at the National Center for Biotechnology Information (NCBI), United States National Library of Medicine (NLM) was searched September 2019 for English language articles published between 2009 and 20...
The prevalence of hair loss, its psychological consequences, and historically subpar treatments present a unique challenge to the physician. The current FDA approved treatments for hair loss are plagued by ineffectiveness, noncompliance and adverse effects. Recently, the understanding of hair physiology has fueled the development of more efficaciou...
The realm of scar therapeutics is constantly changing. Several factors need to be considered when developing a comprehensive treatment plan for scar rehabilitation, including those related to the patient and the nature of the scar. Scar characteristics can be divided by color, scar type and thickness, and body location. Many agents including topica...
Female pattern hair loss (FPHL) is a common nonscarring alopecia characterized by progressive loss of terminal hairs. FPHL is a major concern for women and has a high impact on quality of life. Therapeutic regimen is often challenging and requires multiple combinations of topical, systemic, and interventional therapies to control hair loss and prod...
Androgenetic alopecia (AGA) is a common hair loss disorder caused by genetic and hormonal factors that are characterized by androgen-related progressive thinning of scalp hair in a defined pattern. By the age of 60 years, 45% of men and 35% of women develop AGA. Currently, U.S. Food and Drug Administration-approved treatments for AGA include oral f...
A 25-year-old woman with a history of systemic lupus erythematosus (SLE) was transferred from an outside hospital with a worsening painful generalized rash and oral ulcerations for the prior 3 weeks due to concern for Stevens-Johnson Syndrome / toxic epidermal necrolysis (TEN). Exam revealed denuded erythematous plaques covering over 80% of the pat...
Keratosis pilaris (KP) is a common skin finding that presents as follicular hyperkeratotic papules on the proximal extremities in patients with a propensity for atopy. Although often asymptomatic, the stippled appearance is cosmetically disturbing to patients and difficult to treat as current therapies are limited in availability and efficacy. Nitr...
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can...
Importance
The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s.
Objective
To evaluate the body of literature to provide evidence-based recommendations regarding...
Importance:
Skin cancer is the most common malignancy occurring after organ transplantation. Although previous research has reported an increased risk of skin cancer in solid organ transplant recipients (OTRs), no study has estimated the posttransplant population-based incidence in the United States.
Objective:
To determine the incidence and eva...
The ethnic and racial composition of the US population is changing rapidly. There is a continuous rise of individuals with mixed ethnic backgrounds comprising skin of color. It is important for physicians to be comfortable addressing and treating the needs of this population, as it differs significantly from the white population.
The realm of scar therapeutics is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including those related to the patient and the nature of the scar. Scar characteristics can be divided by color, scar type, and body location. Many agents including topical, intralesional, light- and laser-based...
Keratosis pilaris (KP) is a disorder of follicular keratinization that is characterized by keratin plugs in the hair follicles with surrounding erythema. A 46-year-old man with chronic myelogenous leukemia (CML) was started on nilotinib, a second generation tyrosine kinase inhibitor (TKI). Two months later the patient noticed red bumps on the skin...
Studies using a 755 nm picosecond laser with a focus lens array have been reported to be effective for facial wrinkles and pigmentation. This study reports the safety and efficacy using a shorter interval of 2–3 weeks between treatments. Nineteen female subjects and one male subject, primarily Fitzpatrick skin types II and III (one skin type I), wh...
Immunocompromised individuals are at greater risk for disseminated fungal infections. Immunocompromised individuals in the community have increased because of medical advances, thereby increasing the incidence and prevalence of opportunistic mycoses [1]. The following case series illustrates the importance of having a high clinical suspicion for sk...
A 72-year-old man with a medical history of atrial fibrillation, type 2 diabetes mellitus, chronic kidney disease, hypertension, and congestive heart failure presented with a 2-month history of scaly erythematous papules on both forearms (Figure, A). The lesions were pruritic at times and the patient reported no improvement with chlorhexidine wash...
Erythema nodosum (EN) is the most common form of panniculitis and is a form of septal panniculitis, or inflammation of the fat. It is associated with many conditions including infections (viral, bacterial, fungal, protozoal), pregnancy, medications, autoimmune conditions, and malignancies. Half of all cases are idiopathic. Associated medications th...
Cutaneous drug eruptions are common, compromising approximately 2 % of all drug reactions. Reaction types vary and can be skin-limited or life-threatening. Cutaneous reactions can involve any part of the skin; this section will focus on drug eruptions of the scalp. Adverse cutaneous reactions involving the scalp can be caused my many medications, i...
A 72-year-old man presented with a 2-year history of an asymptomatic rash on the trunk and upper extremities that progressed over 3 months and is aggravated by sunlight. There was no associated fever, joint pain, weight loss, shortness of breath, or malaise. Hismedications included atenolol, simvastatin, triamterenehydrochlorothiazide, aspirin, fen...
Citations
... A significant proportion of dermatologists lack awareness or possess incorrect understanding about cosmetics. In recent years it has been increasingly realized that resident education in this field is essential for training dermatologists who are well-equipped to address the entire spectrum of patient needs (31,32). ...
... A significant proportion of dermatologists lack awareness or possess incorrect understanding about cosmetics. In recent years it has been increasingly realized that resident education in this field is essential for training dermatologists who are well-equipped to address the entire spectrum of patient needs (31,32). ...
... Edelweiss stem cells prevent the destruction of hyaluronic acid and collagen by enzymes. [22] Dobner et al., [23] investigated the L. alpinum and observed that, L. alpinum's had a significant antibacterial activity justifying its traditional usage for the management of abdominal pains, diarrhea, and dysentery. This was in line with literature data performed by Kankaanpää et al. [24] On the other hand, Schmid et al. [25] detected the antisenescence action of an extract of Uttwiler spatlauber stem cells. ...
Reference: CCD-14-135
... Image data collection that does not adequately capture our populations, in lack of representation of all skin types in clinical teaching sets and in datasets used for research, can negatively impact our specialty, leading to bias in algorithms and providers [1,2]. Highquality images are critical for accurate lesion identification for surgical sites after biopsy and for clinical monitoring to improve diagnostic accuracy of individual lesions [3][4][5][6][7]. ...
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... comunicações, medicina, indústria, pesquisa científica e muitos outros campos (DAYAN et al., 2020;TAN et al., 2021;ROHRICH et al., 2022). A radiofrequência é amplamente utilizada na área da estética para tratar uma variedade de preocupações com a pele, emagrecimento, aumento de performance e melhorar a aparência. ...
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... We also searched MD case reports in the last five years and summarized 13 cases ( Table 2) [8,29,[31][32][33][34][35][36][37][38][39][40][41]. Most patients were male (11/13)[8,29,31-34,36-39,41], and all patients (mean age, 58.8 years) had typical disfigurement of benign symmetric lipomatosis. ...
... 33 However, Semsarzadeh N. suggested that the best method for preparing PRP was using the single-spin centrifugal method. 37 Research has shown that activated platelets can release alphagranules, which contain various growth factors such as transforming growth factor-ß (TGF-ß), epidermal growth factor (EGF), VEGF, PDGF, and insulin-like growth factor-1 (IGF-1). 21,27 These growth factors promote angiogenesis, fibroblast proliferation, and collagen synthesis, which in turn improve hair loss. ...
... Mild-to-moderate FPHL can be treated with oral antiandrogen therapies and/or topical minoxidil with good results in many cases. 1 Anti-androgen therapy is used in FPHL if hyperandrogenism is present or if there is a poor response to minoxidil. 33 However, information on their efficacy is limited and they have not been approved by FDA. 33,34 The commonly used antiandrogenic drugs in combination with minoxidil include 5-alpha reductase inhibitors (finasteride, dutasteride), spironolactone, flutamide, and cyproterone acetate. ...
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... LLLT utilizes lasers (600-1,100 nm) to promote hair growth and increase the proportion of anagen HFs, without an invasive procedure (Stevens and Khetarpal, 2018). Until 2023, more than 47 LLLT devices have been designed and approved by the FDA, and there have been multiple clinical studies demonstrating the efficacy of LLLT, which is even more potent than the FDA-approved drugs in some cases (Farivar et al., 2014;Pillai and Mysore, 2021). ...
Reference: Signaling pathways in hair aging
... Several reviews have implicated the immunomodulatory mechanisms of gut microbiota as being important for cutaneous health (Friedrich et al. 2017;Kumar et al. 2014;Lee et al. 2018;. The connection between the gut and skin has been observed in, for example, inflammatory bowel disease (IBD), in which individuals can have various cutaneous manifestations of the disease . ...
Reference: Gut-Skin Axis: Role in Health and Disease
