Shibnath Ghosal's research while affiliated with Banaras Hindu University and other places

Publications (172)

Article
The tannoid principles of the fruits of Emblica officinalis have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin-A (37%) and -B (33%) enriched fraction of fresh juice of Emblica fruits (EOT) was investigated for antioxidant activity against ischemia-reperfusion (IRI)-induced oxidative stress i...
Article
Chemical analysis of organic solvent extractives of ten fossil-taxa (Gymnosperms) of the Paleozoic - Mesozoic ras indicate the chemical preservation of five main classes of naturally occurring compounds, viz. ginkgolic acids, terpenoidal lactones (ginkgolides A & B, bilobalide), biflavones (amentoflavone, bilobetin), procyanidins and anthocyanidins...
Article
Withania somnifera glycowithanolides (WSG) were investigated for their preventive effect on the animal model of tardive dyskinesia (TD), induced by once daily administration of the neuroleptic, haloperidol (1.5 mg/kg, i.p.), for 28 days. Involuntary orofacial movements (chewing movements, tongue protusion and buccal tremors) were assessed as TD par...
Article
Nine extracts of H. perforatum, containing hyperforin in conjugated forms, but devoid of free hyperforin and adhyperforin, were subjected to antidepressant screening using the forced swim test (FST). The observed activity was compared with that of SJW extracts containing hyperforin and adhyperforin (in free form). Results indicate that hyperforin c...
Article
Effects of concomitant administration of Processed Shilajit (PS, 0.1 and 1 mg/kg, i.p.), in Swiss mice were evaluated on the development of tolerance to morphine induced analgesia in the hot plate test. Chronic administration of morphine (10 mg/kg, i.p., b.i.d.) to mice over a duration of 10 days resulted in the development of tolerance to the anal...
Article
The antioxidant activity of Withania somnifera (WS) glycowithanolides was assessed in chronic footshock stress induced changes in rat brain frontal cortex and striatum. The stress procedure, given once daily for 21 days, induced an increase in superoxide dismutase (SOD) and lipid peroxidation (LPO) activity, with concomitant decrease in catalase (C...
Article
The roots of Withania somnifera (WS) are used extensively in Ayurveda, the classical Indian system of medicine, and WS is categorized as a rasayana, which are used to promote physical and mental health, to provide defence against disease and adverse environmental factors and to arrest the aging process. WS has been used to stabilize mood in patient...
Article
Glycowithanolides, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, isolated from the roots of Withania somnifera Dunal, have been reported to have an antioxidant effect in the rat brain frontal cortex and striatum. In the present study, the effect of 10 days of oral administration of these active principles, in grade...
Article
Effect of tannoid principles emblicanin A, emblicanin B, punigluconin, and pedunculagin of E. officinalis was assessed on chronic unpredictable footshock-induced stress-induced perturbations in oxidative free radical scavanging enzymes in rat brain frontal cortex and striatum. Chronic stress, administered over a period of 21 days, induced significa...
Article
The effect of a standardized extract of Bacopa monniera Linn. was assessed on rat brain frontal cortical, striatal and hippocampal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities, following administration for 7, 14 or 21 days. The effects induced by this extract (bacoside A content 82% +/- 0.5%), administered...
Article
The tannoid principles of the fruits of the plant Emblica officinalis Gaertn comprising of emblicanin A. emblicanin B, punigluconin and pedunculagin, have been reported to exhibit antioxidant activity in vitro and in vivo. In the present study, an emblicanin A (37%) and B (33%) enriched fraction of fresh juice of Emblica fruits (EOT), administered...
Article
Members of the genus Wrightia, viz. W. tinctoria, W. tomentosa and W. coccinea, have been investigated for their chemical constituents with a view to locating their bioactive principles. Indigotin 3, indirubin 6, tryptanthrin 8, isatin 5, anthranillate 7 and rutin 9 have been isolated and identified as major constituents of W. tinctoria and W. tome...
Article
In some tropical rain forests organic matter, derived from epiphytic plants, accumulates as heavy mats on tall tree tops (Crown), trunks and branches. Upon microbial and abiotic (chemical, geological) interactions, the canopy organic matter (COM) is transformed into Crown humus. Detailed chemical, chromatographic and spectroscopic analyses of seven...
Article
Xanthones isolated from Hypericum perforatum (St. John's wort, SJW) were subjected to antidepressant and receptor binding studies. Contribution of xanthones to the antidepressant activity of H. perforatum has hitherto not been considered due to the apprehension that this class of compounds occurs in traces in SJW and in commercial Hypericum extract...
Article
Bacopa monniera Wettst. (syn. Herpestis monniera L.; Hindi - Brahmi) is classified in Ayurveda, the classical Indian system of medicine, as Medhyarasayana, a group of plant derived drugs used as nervine tonics to promote mental health and improve memory and intellect. Earlier experimental and clinical studies have demonstrated the memory-promoting...
Article
Full-text available
Ginkgolic acid conjugates (GAC) (6-alkylsalicylates, namely n-tridecyl-, n-pentadecyl-, n-heptadecyl-, n-pentadecenyl- and n-heptadecenylsalicylates) isolated from the leaves of Indian Ginkgo biloba Linn., (IGb) were tested for their putative role in anxiety in rats. Elevated plus maze, open-field behaviour, novelty-induced feeding latency and soci...
Article
The effect of acute administration of Wrightia tinctoria (Wt) (leaves) methanolic extractives, constituting indigotin (HPTLC, relative abundance 21.97%), indirubin (27.13%), tryptanthrin (21%), isatin (2.70%) and rutin (14.24%), was studied on the rat brain concentrations of monoamines and their metabolites in five different brain regions, viz. hyp...
Article
Methylenedioxymethamphetamine (MDMA), commonly known as Ecstasy, is widely abused as a recreational agent. Reports of death following MDMA intake has aroused serious concern. Although some of the clinical symptoms of MDMA toxicity include severe anxiety, panic, excitation and agitation, behavioural studies on the drug are sparse and incomplete. The...
Article
Antioxidant activity of active principles of Withania somnifera, consisting of equimolar concentrations of sitoindosides VII-X and withaferin A, was investigated for their effects on rat brain frontal cortical and striatal concentrations of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX). Results were compared with effec...
Article
Although some promising results have been achieved by acetylcholinesterase inhibitors, an effective therapeutic intervention in Alzheimer's disease still remains an important goal. Sitoindosides VII–X, and withaferin-A, isolated from aqueous methanol extract from the roots of cultivated varieties of Withania somnifera (known as Indian Ginseng), as...
Article
Tryptophan, its methyl ester and hemoglobin have been shown, separately, to produce isatin, among other products, by iron ion-catalyzed oxidation with oxygen free radicals. Chemical and spectroscopic evidence of the oxidation products formed, in presence of mangiferin. indicate that the reaction is effected by a number of discrete steps involving e...
Article
The effect of acute administration of Ginkgo biloba leaf extract of Indian origin (lGb) mainly constituting ginkgolic acid conjugates (1a-e). (and their equivalents) have been evaluated on the concentrations of catecholamines, serotonin and their major metabolites in five different regions of the rodent brain namely, hypothalamus, hippocampus, stri...
Article
Five 6-alkyl (n-tridecyl-, n-pentadecyl-, n-heptadecyl-, n-pentadecenyl- and n-heptadecenyl-) salicylates 1a-e, in free and conjugated (esters, phospholipids) forms, constituting one of the largest classes of bioactive metabolites have been isolated from the leaves and fruits of ten Ginkgo biloba trees of different ages (3-80 years) and indigenous...
Article
Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-beta-D-glucoside) purified from plant sources was shown to have in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Following in vivo or in vitro treatment, it also enhanced tumor cell cytotoxicity of the splenic cells and peritoneal macrophages of normal a...
Article
The origin and inherent molecular similarities of the Ayurvedic Maharasas are depicted. The basic molecular architecture of the Maharasas, e.g. Shilajit, Makshika, Abhraka, and Rasaka, is projected as a multilayer metallo-organic complex (Fig. 1) comprising iron-sulphur cluster (in case of Shilajit and Makshika)-humates, coated with thermostable su...
Article
The effects of subcutaneous (s.c.) administration of processed shilajit (PS) alone and in combination with insulin (s.c.) on plasma glucose levels (PGL) were determined in either sex of streptozotocin-induced diabetic (SID) rats. PS (50 μ/kg; s.c.) did not alter plasma glucose levels in SID rats. Insulin (0.25-1.0 U/kg; s.c.), dose-dependently prod...
Article
The dose- and time-dependent effects of processed shilajit (SJP) on morphometric and functional changes of mouse peritoneal macrophages were evaluated. Several dynamic aspects of cellular modulations were observed in response to SJP treatment (0.025–900 mcg per mouse, i.p.) for different periods of time (0 min to several hours). A plausible mechani...
Article
The active principles of Withania somnifera (WS, 20–50 mg/kg, p.o.), consisting of equimolar amounts of sitoindosides. VII–X and withaferin A, were investigated for putative nootropic activity in an experimentally validated Alzheimer's disease (AD) model. The syndrome was induced by ibotenic acid (IA) lesioning of the nucleus basalis magnocellulari...
Article
The radicophilicity (antiradical–antioxidant effects) of processed shilajit (SJP) to oxygen-derived free radicals and nitric oxide (NO), and the attendant H2O2 cleaving effect were evaluated. SJP provided complete protection to methyl methacrylate (MMA) against hydroxyl radical-induced polymerization and acted as a reversible NO-captodative agent....
Article
Effects of glycowithanolides (Ws, 10–150 mg/kg, i.p.), consisting of sitoindosides VII-X, in combination with withaferin-A, from Withania somnifera, in Swiss mice were evaluated on (i) morphine-induced inhibition of gastrointestinal tract (GIT) transit and (ii) development of tolerance to morphine-induced analgesia. Pretreatment with Ws significant...
Article
The effect of processed shilajit (SJ-P) was evaluated on murine peritoneal macrophages and on the cohabiting fibroblasts. The study revealed a dynamic aspect of modulation of the peritoneal cells by SJ-P (200–600 mcg/mouse), when administered intraperitoneally. The findings further suggested that by carefully determining the dose, SJ-P can be used...
Article
Mangiferin, a C-glucosylxanthone (1,3,6,7-tetrahydroxyxanthone-C2-β-D-glucoside), isolated from several plant sources, was shown to be effective in activating murine peritoneal macrophages. It acted as a strong inducing agent with a peak elicitation response at 48 h interval of treatment (10 μg mangiferin/g body weight, g b.w). The mangiferin-elici...
Article
Shilajit (25 and 50 mg/kg i.p. for 5 days) significantly lowers the levels of 5HT and 5HIAA and increases the levels of DA, NA and their metabolites, in concert, in rat brain. The finding is appraised in view of its use as an Ayurvedic rasayan (rejuvenator).
Article
The nature of the building blocks and their alignments in the humus 'core' of shilajit were determined by mild and drastic degradations and by comprehensive spectroscopic analyses of the products. Mild hydrolysis of humic acids (HAs) from shilajit afforded two new dibenzo-alpha-pyrones, viz. 3-O-palmitoyl-8-hydroxydibenzo-alpha-pyrone (1) and 3-O-b...
Article
Shilajit, a panacea of oriental medicine, collected from different countries, exhibits overtly different levels of bioactivity. The effects of shilajit, collected from India, Nepal, Pakistan and Soviet Russia, and the effects of organic constituents isolated from a potent shilajit sample, were studied in a number of antistress and CNS activity para...
Article
The biochemical role of free and conjugated alkaloids in the fruits of Crinum asiaticum during strees (incisional injury and attack by an insect) is appraised. Wounding of C. asiaticum fruits caused almost complete hydrolysis of the alkaloidal conjugates and also produced oxidized metabolises of lycorine and its analogues. Prior treatment of fruits...
Article
The isolation and structure of the reactive benzopyrone (I), a crucial intermediate to the bioactive dibenzopyrones (II) from shilajit, a panacea in oriental medicine, as well as the synthesis of (IIc) are described.
Article
Two new epimeric pyrrolophenanthridine alkaloids, 2-epilyocorine and 2-epipancrassidine, were isolated from the flower-stem fluid of Crinum latifolium. The structures of the two alkaloids were established by spectroscopic analyses, crucial chemical transformation, and synthesis in case of the former. The differences in the metabolic pathways of lyc...
Article
Two new isocarbostyril alkaloids, 7-deoxypancratistatine and pancratiside (= pancratistatine-2-O-β-d- glucoside), were isolated from the resting bulbs of Haemanthus kalbreyeri. The structures of the two alkaloids were established by comprehensive spectral analyses and chemical transformations. The plant growth regulatory profile of these two alkalo...
Article
Two new dimethoxy-acetophenone-O-glucosides and the known 2,4,6-trimethoxyacetophenone were isolated from the flowering bulbs and pseudo-stem fluid of Pancratium biflorum. The structures of the new compounds were established as 4,6-dimethoxyacetophenone-2-O-β-d-glucoside and 2,6-dimethoxyacetophenone-4-O-β-d-glucoside on the basis of chemical trans...
Article
The effects of shilajit and the combined effects of its main constituents, fulvic acids (FAs), 4′-methoxy-6-carbomethoxybiphenyl (MCB) and 3,8-dihydroxy-dibenzo-α-pyrone (DDP), were studied in relation to the degranulation and disruption of mast cells against noxious stimuli. Shilajit and different combinations of FAs, MCB and DDP provided statisti...
Article
Two new glycowithanolides, sitoindoside IX (1) and sitoindoside X (2), isolated from Withania somnifera Dun., were evaluated for their immunomodulatory and CNS effects (anti-stress, memory and learning) in laboratory animals, because the plant extract is used by practitioners of the Indian systems of medicine for similar purposes. The two compounds...
Article
The effects of shilajit and the combined effects of its main constituents, fulvic acids (FAs), 4'-methoxy-6-carbomethoxybiphenyl (MCB) and 3,8-dihydroxy-dibenzo-α-pyrone (DDP), were studied in relation to the degranulation and disruption of mast cells against noxious stumuli. Shilajit and different combinations of FAs. MCB and DDP provided statisti...
Article
Differences in the low- and medium Mr phenolic and steroidal compounds in healthy and malformed florets of Mangifera indica, the latter infested with Fusarium moniliforme var. subglutinans (IMI 225231), and in those intentionally infected with this fungus are reported. The biochemical significance of the changes in these constituents, resulting fro...
Article
A new Schiff's base, named isocraugsodine, was isolated from the fruits of Crinum asiaticum. Its N-(3- methoxy-4-hydroxybenzylidene)- 4′-hydroxyphenethylamine structure was assigned on the basis of chemical trans- formation and comprehensive spectroscopic evidence. The temperature-gradient distribution of the three isomeric forms (1a⇌1b⇌1c) of the...
Article
Fulvic acids (FA) and 4′-methoxy-6-carbomethoxybiphenyl (MCB, 1), two major organic compounds isolated from Shilajit (a humus product), were screened for anti-ulcerogenic activity in albino rats. Both FA and MCB showed significant anti-ulerogenic effects in the battery of tests accepted for this purpose. The mechanism of anti-ulcerogenic action was...
Article
The effect of glucan A and phosphatidyllycorine, isolated from Crinum latifolium L. (family Amaryllidaceae) was studied on the rate of degranulation of mast cells of albino rats. Different combinations of glucan A and phosphatidyllycorine (5–20 and 5–10 μg/mL, respectively) in vitro, produced statistically significant protection against Tween 80-in...
Article
The role of ungeremine (2), a natural metabolite of lycorine (1), in the growth-inhibitory and cytotoxic effects of 1 is evaluated. Ungeremine produced marked antibacterial action against ten bacterial isolates and significantly inhibited testicular metabolism in mice, and the growth and viability of S-180 tumour cells. Lycorine did not exhibit any...
Article
Four new alkaloidal phospholipids, 2-O-glycerophosphoryllycorine, phosphatidyllycorines, phosphatidylpseudolycorines and phosphatidyllycorinium methocation, were isolated from the flowers of Zephyranthes flava. The structures of these compounds were established by comprehensive spectral analyses, chemical transformations and synthesis, where possib...
Article
Mangiferin, a naturally occurring glucosylxanthone, was assessed for its immunomodulatory potential. The phytochemical induced extensive in vitro proliferation of murine splenocytes and thymocytes at the doses of 5-40 micrograms ml-1. Suppression of the proliferative response of the cells was observed with higher doses of mangiferin. Mangiferin als...
Article
Sitoindoside-IV (= sitosterol 3-[2″-O-palmitpyl-myo-inosityl-(1″ → 6′)-β-D-glucopyranoside]), isolated from Musa paradisiaca L., in doses of 100-400 µg/mouse, when administered over a span of time (3 to 7 days) produced statistically significant mobilization and activation of peritoneal macrophages. The increased cellular activity, as indicated by...
Article
Three recognized mycotoxins, viz. diaxetoxyscirpenol, T-2 toxin and zearalenone, along with the fatty esters of these toxins were isolated from the flask culture extractives of Fusarium oxysporum Schlecht (IMI 273220) as also from seeds of Brassica campestris var. sarson (mustard) infected with this fungus in storage. Evaluation of biological activ...
Article
Two new acylsterylglucosides, sitoindoside VII and sitoindoside VIII, were isolated from the roots of Withania somnifera Dun., and were screened for putative anti-stress activity because the plant is widely regarded as the ‘Indian Ginseng’ by practitioners of the traditional Indian system of medicine. Since an acceptable paradigm of pharmacological...
Article
The effect of lycoriside, an acylglucosyloxy alkaloid from Crinum asiaticum Linn, (family Amaryllidaceae), with or without sitosterol-3-O-β-D-glucoside, was studied on the rate of degranulation of peritoneal mast cells of albino rats. Lycoriside, at lower concentrations (1-20 µg/ml), in vitro, produced statistically significant protection against T...
Article
From fresh, mature seeds of Zephyranthes flava, two new 2-oxyphenanthridinium alkaloids, zefbetaine and zeflabetaine along with 15 known free and glucosyloxy alkaloids have been isolated by gradient solvent extraction, chromatography and derivatization. The new compounds have been characterized by comprehensive spectroscopic analyses, chemical tran...
Article
A rare incidence of phanerogamic parasitism of Imperata cylindrica on Pancratium biflorum and the concomitant changes in the chemical constituents, from the hypersensitive responses in the host species, are reported.
Article
Three recognized 12,13-epoxytrichothecene mycotoxins, trichothecolone, diacetoxyscirpenol, and T-2 toxin, and a hyperestrogenic factor, zearalenone, together with the fatty acid esters of trichothecolone, scirpenetriol, T-2 tetraol, and zearalenone, were isolated from the flask culture extractives of Fusarium moniliforme Sheldon (IMI 225232) as wel...
Article
The current staus of research of free and glycosylated alkaloids occuring in members of the genus Crinum is reviewed. The distribution, isolation, spectral properties, structural properties, inter conventions and biological acitivities of these alkaloids are presented.
Article
The isolation and determination, by spectroscopic analyses and chemical correlation, of the structure and stereochemistry of (+)-epimaritidine, a new alkaloid from Zephyranthes rosea, is reported. A facile transformation of maritidine to (+)-epimaritidine is described and the mechanism is appraised in the light of the thermodynamic stability of the...
Article
From peeled fruits of Musa paradisiaca (banana, vegetable variety), two new acyl steryl glycosides, sitoindoside-III and sitoindoside-IV, and two new steryl glycosides, sitosterol gentiobioside and sitosterol myo-inosityl-β-D-glucoside, have been isolated by gradient solvent extraction and extensive chromatography (CC, prep. TLC, GC and HPLC). The...
Article
The roots of Haemanthus kalbreyeri contain a new phenanthridone alkaloid, kalbretorine, and a new glucosyloxy alkaloid, kalbreclasine. Additionally, six known alkaloids, viz. haemanthamine, haemanthidine, hippadine, lycorine, narciclasine and pratorimine, previously reported from other Amaryllidaceous plants have now been isolated also from this sp...
Article
From the roots of Hoppea dichotoma, collected before flowering, two new naturally occurring glucosyloxyflavans, dichotosin and dichotosinin, have been isolated and characterized by means of comprehensive spectral analyses, chemical transformation and synthesis of the aglucone of dichotosin. This is the first report of dichotosinin from a natural so...
Article
A new optically active flavan aglucone, 7-hydroxy-3′,4′-methylenedioxyflavan, and its 7-glucoside have been isolated from the bulbs of Zephyranthes flava, collected at flowering. Additionally, two known flavans, 7,4′-dihydroxy-3′-methoxyflavan and 7-methoxy-2′-hydroxy-4′,5′-methylenedioxyflavan, have been isolated for the first time from this speci...
Article
Two new types of alkaloidal conjugates, a C16-acyloxy derivative, named palmilycorine, and an acylglucosyloxy derivative, named lycoriside, were isolated from the fruits of Crinum asiaticum. The presence of these compounds was also detected in the fleshy scale leaves and in roots of this species. The structures of the two compounds were established...
Article
The naturally occurring free and glycosylated flavans are reviewed. The distribution, methods of isolation and structure elucidation of flavans, by comprehensive spectral analyses, are presented. Biological properties of flavans are appraised.
Article
From fluids of flower stems and bulbs, and from extracts of roots of Pancratium biflorum, collected at different stages of growth, three new glucosyloxy alkaloids, viz. hordenine-4-O-β-d-glucoside, lycorine-1-O-β-d-glucoside and pseudolycorine-1-O-β-d-glucoside, have been isolated and characterized. Additionally, three proto alkaloids, β-phenethyla...
Article
Female albino rats, treated with mangiferin at daily doses of 5 mg/100 g ip for 3 days during mid-gestation, showed complete fetal resorption. Administration of a mangiferin-Cu(2+) (1:1) complex, along with mangiferin, attenuated the effect of mangiferin and restored the completion of gestation in 60% of the rats. The mother rats that completed ges...
Article
A new polyoxygenated chromone-C-glucoside, named biflorin, was isolated from the roots of Pancratium biflorum collected at flowering time. The
Article
From the bulbs of Crinum latifolium, collected at flowering, two new pyrrolophenanthridone alkaloids, pratorimine and pratosine, have been isolated and characterized on the basis of comprehensive spectral analyses, chemical transformation and synthesis. Additionally, four known alkaloids, hippadine, pratorinine, ambelline and lycorine, encountered...
Article
Full-text available
Hippadine, an alkaloid of the Amaryllidaceae, produced reversible inhibition of fertility in male rats. A decrease in the testicular weight and DNA content and an increase in protein concentration indicated a fall in the relative proportion of freshly divided cells. The weights of accessory sex organs revealed continued production of androgens. A p...
Article
Four 12,13-epoxytrichothecenes, viz., 4-O-acetyltrichothecolone (1), 4-O-cinnamoyltrichothecolone (2), trichothecolone (3), and trichothecin (4), were isolated and characterized from anise fruits infected in fields with Trichothecium roseum van Beyma (CMI-IMI 225229). Among these compounds, 1 and 2 are naturally occurring new 12,13-epoxytrichothece...
Article
Three types of alkaloidal constituents, viz., beta-phenethylamines, quinazolines and carboxylated tryptamines, in addition to choline and betaine have been isolated from Sida acuta Burm., S. humilis Willd., S. rhombifolia L., and S. spinosa L. and characterized by their physical and spectral properties, and by chemical transformations. The qualitat...
Article
A new triterpenoid saponin, named justicisaponin-I, has been isolated from Justicia simplex D. Don. (Acanthaceae). It has been assigned oleanolic acid-3-O-beta-D-glucopyranosyl-4'-O-ferulate structure (1) on the basis of chemical transformation and comprehensive spectral evidence. Justicisaponin-I has produced significant sperm acrosomal membrane s...
Article
Four B-ring oxygen-free trioxygenated xanthones, viz. 1-OH-2,3-(OMe)2-, 1,2,3-(OMe)3-, 1-OH-2,3- (OCH2O)-, 1-OMe-2,3-(OCH2O)-xanthone, two B-ring oxygen-free glucosyloxyxanthones, viz. 1-O-gl.-2-OH-3-OMe- and 1-O-gl.-2,3-(OCH20)-xanthone, and a pentaoxygenated xanthone, 1-OMe-2,3,6,7-(OCH2O)2-xanthone, have been isolated from the flowering top of P...
Article
From the bulbs of Crinum pratense, collected at flowering, lycorine, 1,2-diacetyllycorine, ambelline, narcissidine, and three phenanthridone alkaloids, viz. hippadine, pratorinine and anhydrolycorin-7-one, were isolated and characterized on the basis of comprehensive spectral analyses (UV, IR, 1H NMR, 13C NMR, MS, [α]D) and chemical evidence. Among...
Article
A new 3,7-dioxabicyclo[3,3,O]octane lignan, named justisolin, and a new lignan O-glucoside, named simplexoside, were isolated from the whole plant of Justicia simplex D. Don. (Acanthaceae), collected at fruiting. The structure of the free lignan was established as 2e-(3,4-methylenedioxy-6-hydroxy)-phenyl-6e- Piperonyl-3,7-dioxabicyclo[3,3,0]octane...