Shevon E. Bhattacharya’s scientific contributions

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Publications (1)


Attention enhancing effects of methylphenidate are age-dependent
  • Article

November 2014

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38 Reads

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16 Citations

Experimental Gerontology

Shevon E. Bhattacharya

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Barry D. Waterhouse

The psychostimulant methylphenidate (MPH, Ritalin®) is used to treat a variety of cognitive disorders. MPH is also popular among healthy individuals, including the elderly, for its ability to focus attention and improve concentration, but these effects have not been shown to be comparable between aged and adult subjects. Thus, we tested whether MPH would improve performance in sustained attention in both adult and aged rats. In addition, we tested the impact of visual distraction on performance in this task and the ability of MPH to mitigate the effects of distraction. Adult (6–12 months) and aged (18–22 months) male Sprague–Dawley rats were given oral MPH, and their cognitive and motor abilities were tested. Results suggest that while MPH improves task performance in adults; there is no improvement in the aged animals. These outcomes suggest that the use of MPH for cognitive enhancement in elderly individuals may be ineffective.

Citations (1)


... Dose-related increments were observed in tracking performance and attention in the CTT and DAT, processing speed and cognitive flexibility in the DSST, spatial memory in the SMT, and performance efficiency in the MFFT. Similar improvements in neurocognitive function have been documented for various stimulant drugs, including cocaine, MDMA, amphetamine, modafinil, methylphenidate [42][43][44][45][46][47][48][49][50][51] and designer drugs such as 4-FA [38]. Psychostimulant properties of amphetamine-like compounds have long been recognized and utilized in medical applications to treat attention deficit disorders [52,53], and in military applications to maintain and sustain vigilance during operations [54,55]. ...

Reference:

Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study
Attention enhancing effects of methylphenidate are age-dependent
  • Citing Article
  • November 2014

Experimental Gerontology