Shelby Coates's research while affiliated with Washington State University and other places
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Publications (3)
Cannabis-based products have experienced notable increases in co-usage alongside tobacco products. Several cannabinoids exhibit inhibition of a number of cytochrome P450 (CYP) and UDP glucuronosyltransferase (UGT) enzymes, but few studies have examined their inhibition of enzymes involved in nicotine metabolism. The goal of the present study was to...
Introduction
Cannabis is an increasingly popular recreational and medicinal drug in the USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on its use. With its increased usage, there is an increased potential for potential drug-drug interactions (DDI) that may occur with concomitant use of cannabis and pharmac...
Opioids including morphine are mu-opioid receptor (MOR) agonists that suppress excitatory neurotransmitter release, hyperpolarize neuronal cells, and decrease overall excitability, resulting in the desired analgesic effect. As a result of their over-prescription, the still-growing opioid epidemic has devastated many communities, with many individua...
Citations
... 50,54 CBD and its metabolites are lipophilic and there is evidence of bioaccumulation, particularly in adipose and brain tissues to some extent while the acids such as CBDA appear to undergo less bioaccumulation in brain tissue, yet are still present, albeit at lower concentrations than CBD. 55,56 Recent work in Guinea pigs examining adipose and cartilage tissues shows that the bioaccumulation of CBD does occur primarily in the patellar fat pad and much less so in cartilage. 57 Work in beef cows examining contaminated hempseed cake also shows CBD and CBDA in liver and kidney tissue at low concentrations lower than what was found in plasma, suggesting similarly to people that organs do not show significant bioaccumulation while adipose can be a modest repository for cannabinoids to some extent. ...
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