Shauna L. French's research while affiliated with Harvard Medical School and other places
What is this page?
This page lists the scientific contributions of an author, who either does not have a ResearchGate profile, or has not yet added these contributions to their profile.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
It was automatically created by ResearchGate to create a record of this author's body of work. We create such pages to advance our goal of creating and maintaining the most comprehensive scientific repository possible. In doing so, we process publicly available (personal) data relating to the author as a member of the scientific community.
If you're a ResearchGate member, you can follow this page to keep up with this author's work.
If you are this author, and you don't want us to display this page anymore, please let us know.
Publications (4)
Background
The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets which are cellular extensions originating from the MK cell body.
Objectives
Proplatelet formation is an asynchronous and dynamic pro...
During inflammation, steady-state hematopoiesis switches to emergency hematopoiesis to repopulate myeloid cells, with a bias toward the megakaryocytic lineage. Soluble inflammatory cues are thought to be largely responsible for these alterations. However, how these plasma factors rapidly alter the bone marrow (BM) is not understood. Inflammation al...
Megakaryocytes are hematopoietic cells, which are responsible for the production of blood platelets. The traditional view of megakaryopoiesis describes the cellular journey from hematopoietic stem cells, through a hierarchical series of progenitor cells, ultimately to a mature megakaryocyte. Once mature, the megakaryocyte then undergoes a terminal...
Citations
... 4 In our recent work, we have focused on cell surface area, perimeter, circularity (FormFactor), pseudopodia (endpoint) number, and total pseudopodia length. 1 Examples of the processing steps from which these outputs are measured are seen in Figure 2. Cell morphology characteristics have been shown to change under various conditions, such as chronic stress. 1 Protocols similar to this have also been used in other biological contexts and cell types, demonstrating the broad applicability of quantifying cell morphology. 8,9 Cell morphology phenotypes can be indicative of organism characteristics; for example, differences in cell morphology have been associated with donor age more closely than other established biomolecular measurements such as DNA damage response or adenosine triphosphate content. 10 ...
... They are involved in superoxide generation and enhance fibrin binding. Platelet-derived extracellular vesicles also induce platelet activation by collagen receptors [42,43]. UC-MSC-derived EVs suppress ROS-induced apoptosis through the suppression of AIF nuclear translocation and PARP-1 activation [44]. ...
![[object Object]](https://i1.rgstatic.net/ii/profile.image/921580813168645-1596733396728_Q64/Kirill-Butov.jpg)
![[object Object]](https://i1.rgstatic.net/ii/profile.image/11431281103994298-1669911304360_Q64/Kellie-Machlus.jpg)
... IL-6 production can affect both stromal and hematopoietic cells, for example, stimulating megakaryocyte (Mk) growth and maturation in vitro as well as increasing Mk ploidy. Moreover, some authors have recently reported that abnormal levels of IL-6 might interfere with the stability of the bone marrow hematopoietic microenvironment [30,31]. It was already reported that IL-8 is also responsi-ble for the enhanced proliferation and mobilization of HSCs in the bone marrow [32]. ...
... During inflammation, steady-state hematopoiesis switches to emergency hematopoiesis to repopulate myeloid cells, with a bias toward the megakaryocyte (MK) lineage. [1][2][3][4] MKs are derived from hematopoietic stem cells (HSCs) that reside mainly in the bone marrow (BM) and are responsible for platelet production. 5 During many inflammatory states, platelet production becomes dysregulated and can present as thrombocytopenia or thrombocytosis. ...
