Sharon L. Brennan-Olsen's research while affiliated with University of Melbourne and other places

Publications (155)

Article
Introduction The early years of a child’s life (including the in-utero environment) have an important influence on their immediate and long-term developmental and health outcomes. Intervening as early as possible is key to preventing these consequences. Effective engagement with perinatal services during pregnancy and the postnatal period can have...
Article
Note: We respectfully refer to Aboriginal and Torres Strait Islander people as Indigenous in this study. Objective: To design and develop an Indigenous specific suicide intervention skills program that focuses on education and intervention training as an effective suicide prevention strategy. Method: Using a co-designed wrap-around framework, w...
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This study identified the costs and health-related quality of life impacts of several post-fracture multidisciplinary care pathways specific to individual skeletal site (hip, distal forearm, vertebrae, humerus). These care pathways may assist healthcare providers in allocating resources for osteoporotic fractures in more effective and cost-efficien...
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Introduction Low health literacy is common in people with cardiovascular disease and may be one factor that affects an individual’s ability to maintain secondary prevention health behaviours following myocardial infarction (MI). However, little is known about the association between health literacy and longer-term health outcomes in people with MI....
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Background Bipolar disorder (BD) is associated with significant psychological and physical comorbidity. Yet little is known about the bone health of individuals with BD. Thus, we aimed to investigate the association between BD and bone health in a population-based sample of women. Methods Women with a history of BD (n = 117) were recruited from pu...
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Objectives Aboriginal and Torres Strait Islander Australians have a substantially greater fracture risk, where men are 50% and women are 26% more likely to experience a hip fracture compared with non-Indigenous Australians. Fall-related injuries in this population have also increased by 10%/year compared with 4.3%/year in non-Indigenous Australians...
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Background It is not known how measures of body composition, strength and physical performance are interrelated or how empirical groupings of these measures relate to disability and mobility disability. Methods Muscle mass was assessed by D3-creatine dilution (D3Cr muscle mass) in 1345 men (84.1 ± 4.1 years) enrolled in the Osteoporotic Fractures...
Chapter
This multidisciplinary chapter discusses the social context of osteosarcopenia: often a neglected area of consideration for this geriatric condition. It begins by discussing the evidence regarding associations between social conditions and lifestyle risk factors for osteosarcopenia. It then argues that lifestyle risk factors during childhood and ad...
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Little is known about factors that lead to excess mortality post-fracture. This study demonstrated that 5-year mortality is lower in older adults who recovered to their pre-fracture health-related quality of life (HRQoL) at 12-months compared to those who did not recover. Our results highlight the importance of post-fracture interventions known to...
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We investigated and quantified the predictability of frailty associated with musculoskeletal parameters. This longitudinal study included 287 men aged ≥ 50 yr at baseline (2001–2006) from the Geelong Osteoporosis Study. Baseline musculoskeletal measures included femoral neck bone mineral density (BMD), appendicular lean mass index (ALMI, kg/m2) and...
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Background Musculoskeletal conditions and physical frailty have overlapping constructs. We aimed to quantify individual contributions of musculoskeletal factors to frailty. Methods Participants included 347 men and 360 women aged ≥60 yr (median ages; 70.8 (66.1–78.6) and 71.0 (65.2–77.5), respectively) from the Geelong Osteoporosis Study. Frailty...
Article
Background Social disadvantage may contribute to increased prevalence of sarcopenia and obesity. This study investigated if socioeconomic factors are associated with obesity, sarcopenia, or sarcopenic obesity (SO), in community-dwelling older adults. Methods This was a cross-sectional analysis of data from the Tasmanian Older Adult Cohort study. O...
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In this study of 695 Australian older adults (aged ≥50 years), we found that men and women had a similar trajectory of health-related quality of life (HRQoL) recovery following fragility fracture at any skeletal site. These results provide us with critical knowledge that improves our understanding of health outcomes post-fracture.IntroductionMortal...
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Objective: To generate outcomes for the development of a culturally appropriate mental health treatment model for Indigenous Australians with depression. Methods: Three focus group sessions and two semi-structured interviews were undertaken over six months across regional and rural locations in South West Queensland. Data were transcribed verbat...
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Background Reference ranges for lean mass (LM) and fat mass (FM) are essential in identifying soft tissue disorders; however, no such reference ranges exist for the most commonly used Hologic dual‐energy X‐ray absorptiometry (DXA) machine in Australia. Methods Cross‐sectional study of community‐dwelling adults (aged 18–88 years) who underwent a Ho...
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Background/objectives To derive dietary patterns and examine their longitudinal associations with sociodemographic and lifestyle factors in the Tasmanian Older Adult Cohort. Subjects/methods This is a corrected analysis of a retracted paper. We followed 1098 adults aged ≥50 years for 5 years. Dietary intake was assessed using a validated food freq...
Article
PurposeTo investigate the association between serum interleukin-6 (IL-6) and frailty.Methods Participants were 581 men aged 60–90 yr (median (IQR): 74 yr (67–83 yr)) from the Geelong Osteoporosis Study. Tallies of ≥ 3, 1–2 and 0 for weight loss/exhaustion/physical-inactivity/slowness/weakness indicated frailty, pre-frailty and robustness, respectiv...
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Purpose We aimed to identify combinations of health service use specific to each major osteoporotic fracture (MOF) site – hip, distal forearm, vertebrae and humerus – associated with recovery of health-related quality of life (HRQoL) 12-months post-MOF. Methods Patients were 4126 adults aged ≥50 years with a MOF (1657 hip, 1354 distal forearm, 681...
Article
Purpose To investigate wellbeing and work impacts in younger people with persistent shoulder pain. Materials and methods People aged 20–55 years with shoulder pain of >6 weeks’ duration (excluding those with recent fracture or dislocation) were recruited from orthopaedic clinics at three major public hospitals. Health-related quality of life (HRQo...
Article
Objectives: We aimed to investigate fracture risk associated with anticonvulsant use in a population-based sample of men and women. Methods: Data from 1,458 participants (51.8% women) with a radiologically confirmed incident fracture (cases) were compared to 1,796 participants (46.5% women) without fracture (controls). Lifestyle factors, medicat...
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Background Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods Data from 926 men (24-73 yr) and 1070 women (21-94 yr) participating in the Geelong Osteoporosis Study were included. Bone miner...
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Previously we have reported an association between maternal vitamin D and offspring bone as measured by dual-energy X-ray absorptiometry. It is plausible that shared genetics might confound associations between maternal vitamin D in pregnancy and offspring bone measures. We aimed to determine whether such associations are independent of maternal bo...
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https://onlinelibrary.wiley.com/share/QIEUC85C3PBSHTG4NA7X?target=10.5694/mja2.50925
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Background Personality disorder (PD) may affect the efficacy of pharmacological interventions for mood disorders, but the extent to which this occurs is uncertain. We aimed to examine the available published evidence concerning the role of PD in pharmacological treatment outcomes of randomised controlled trials (RCTs) for adults with mood disorders...
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Background Care pathways are generally paper-based and can cause communication failures between multidisciplinary teams, potentially compromising the safety of the patient. Computerized care pathways may facilitate better communication between clinical teams. This study aimed to investigate whether an electronic care pathway (e-pathway) reduces del...
Article
Background: A socioeconomic gradient exists in the utilisation of total hip replacements (THR) and total knee replacements (TKR) for osteoarthritis. However, the relations between socioeconomic status (SES) and time to THR or TKR is unknown. Aim: To describe the association between SES and time to THR and TKR. Methods: 1072 older-adults residi...
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Objectives: To examine associations of education and occupation with handgrip strength (HGS), lower limb strength (LLS) and appendicular lean mass (ALM). Methods: Measures of HGS, LLS and ALM (dual-energy X-ray absorptiometry) were ascertained at baseline in 1090 adults (50-80 years, 51% women), ~3 and 5 years. Education and occupation were self...
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Major osteoporotic fractures (MOFs) are associated with a rapid decline of health-related quality of life (HRQoL), however there is limited knowledge about which health care services positively affect HRQoL post-fracture. This study aimed to identify specific combinations of health service use associated with recovery of HRQoL 12-months post-MOF. T...
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Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60–90 years) enrolled in the Geelong Osteoporosis Study. Frailty...
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Few studies have investigated the prevalence of frailty in the Australian general population. This study determined the prevalence of frailty in a population-based sample of older adults and examined the relationship between frailty and comorbid conditions. Men (n = 347) and women (n = 360) aged ≥ 60 year from the Geelong Osteoporosis Study (GOS) w...
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Purpose The Vitamin D in Pregnancy Study is a long-term ongoing cohort study. It was conceived to explore relationships between maternal vitamin D status in pregnancy and offspring growth and development, and has since diversified to include a wide range of physical and mental health exposures and outcomes. Participants Recruitment was from the Un...
Article
Objectives Sarcopenia Definitions and Outcomes Consortium (SDOC) provides cut-points based on muscle weakness (low grip strength) and slowness (poor gait speed) for low-risk populations; however, it is unknown if these criteria apply to high-risk populations. We examined the association between SDOC criteria and important health status indicators i...
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Post-puberty, bone mass displays clear sex-specific patterns. However, research has suggested that a sexual dimorphism in bone mass is evident in younger children and is likely attributable to differences in lean mass. Thus, we aimed to determine whether the association with both overall muscle mass and/or muscle strength was different between the...
Preprint
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Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods: Data from 926 men (24-73yr) and 1070 women (21-94yr) participating in the Geelong Osteoporosis Study were included. Bone minera...
Preprint
Full-text available
Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods: Data from 926 men (24-73yr) and 1070 women (21-94yr) participating in the Geelong Osteoporosis Study were included. Bone minera...
Preprint
Full-text available
Background: Anticonvulsant use has been linked to bone deficits in specific patient populations. We studied the association between anticonvulsant use and bone health in a population-based sample of men and women. Methods: Data from 1996 people, 926 men (age:24-73y) and 1070 women (21-94y) participating in the Geelong Osteoporosis Study were includ...
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A systematic review of prediction models/questionnaires developed to identify people with deficient/insufficient vitamin D status shows the potential of self-reported information to estimate vitamin D status. The objective is to identify and compare existing screening tools, developed to identify vitamin D deficiency or insufficiency in adults. A s...
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Background: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. Methods: In cross-sectional analysis, frailt...
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Background In order to develop and implement prevention strategies for falls, comprehensive epidemiological data are required. Therefore, this study mapped emergency presentations for falls across the western region of Victoria, Australia, encompassing urban, regional and rural areas. Methods This cross-sectional study utilised electronic data for...
Article
Rationale Suicide prevention training in Aboriginal and Torres Strait Islander communities is a national health priority in Australia. Objective This paper describes a qualitative study to increase understanding of how a mobile application (app) could be used to support suicide prevention gatekeepers in Indigenous communities. We respectfully use...
Article
Objectives It is unknown whether muscle mass measured by the D3-creatine dilution method is a superior predictor of incident mobility disability than traditional components of sarcopenia definitions (including grip strength, walking speed, appendicular lean mass). The objective of this study was to determine the relative importance of strength; phy...
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Background A four- to seven-fold increase in the prevalence of current mood, anxiety, substance use and any mental disorders in Indigenous adults compared with non-Indigenous Australians has been reported. A lifetime prevalence of major depressive disorder was 23.9%. High rates of comorbid mental disorders indicated a transdiagnostic approach to tr...
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Australian Indigenous model of mental healthcare based on transdiagnostic cognitive–behavioural therapy co-designed with the Indigenous community: protocol for a randomised controlled trial – CORRIGENDUM - Volume 6 Issue 3 - Maree Toombs, Bushra Nasir, Steve Kisely, Srinivas Kondalsamy-Chennakesavan, Leanne Hides, Neeraj Gill, Gavin Beccaria, Sharo...
Article
Purpose: To investigate the association between bone mineral density (BMD) and the severity of sarcopenia using the revised European Working Group on Sarcopenia in Older People (EWGSOP2) definition. Methods: BMD [dual energy X-ray absorptiometry (DXA)], appendicular lean mass (DXA), handgrip strength (hydraulic dynamometer) and gait speed (over 4-...
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Introduction Little is known about the bone health of adults with bipolar disorder, aside from evidence purporting bone deficits among individuals with other mental illnesses, or those taking medications commonly used in bipolar disorder. In this paper, we present the methodology of a case–control study which aims to examine the role of bipolar dis...
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Contemporary data are required to plan interventions and identify gaps in health service provision. As part of the larger Ageing, Chronic Disease and Injury study, we mapped joint replacements across the western region of the Australian state of Victoria. Primary total joint replacement data were extracted from the Australian Orthopaedic Associatio...
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Identification of sarcopenia in lower- and middle-income countries (LMICs) is limited by access to technologies that assess muscle mass. We investigated associations between two functional measures of sarcopenia, grip strength and gait speed (GS), with functional disability in adults from six LMICs. Data were extracted from the World Health Organiz...
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On July 1st 2019, sarcopenia was awarded an Australian ICD-10-AM code. In this letter we summarise an approach to older adults living with sarcopenia and outline the potential benefits of ICD-10-AM recognition.
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Objectives We sought to examine the associations of osteosarcopenia with physical performance, balance, and falls and fractures in community-dwelling older adults. Additionally, we aimed to determine which clinical outcomes are associated with specific components of osteosarcopenia. Design Cross-sectional study. Setting and Participants 253 parti...
Article
Background: In order to implement intervention strategies to prevent falls from height, epidemiological data are needed. The aim of this study was to map emergency presentations for falls from height in residents aged ≥40 yr of the western region of Victoria, Australia. Methods: Emergency presentations following a fall from height (≥1 m) were ob...
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Context: Worldwide, cancer is the second leading cause of death, with a rapidly increasing global incidence: it is present in high and in lower-middle income countries (LMICs). Overweight and obesity are also a major global health concern, and while they were once considered conditions specific to the ‘Western’ world, this geographic patterning has...
Article
Abstract Summary These data present associations between socioeconomic status (SES), different types of childhood maltreatment (CM) history and family dysfunction, and arthritis in men and women across a wide age range. Arthritis was less likely among those with higher SES, regardless of CM history. Introduction CM has been associated with increase...
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Background: Cancer is a leading burden of disease in Australia and worldwide, with incidence rates varying with age, sex and geographic location. As part of the Ageing, Chronic Disease and Injury study, we aimed to map the incidence rates of primary cancer diagnoses across western Victoria and investigate the association of age, accessibility/remo...
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Osteopenia/osteoporosis and sarcopenia are both age-related conditions. Given the well-defined bone and muscle interaction, when osteopenia and sarcopenia occur simultaneously, this geriatric syndrome is defined as ‘osteosarcopenia’. Evidence exists about therapeutic interventions common to both bone and muscle, which could thereby be effective in...
Article
Background: In order to develop and implement prevention strategies for falls, comprehensive epidemiological data are required. Therefore, this study mapped emergency presentations for falls across the western region of Victoria, Australia, encompassing urban, regional and rural areas. Methods: This cross-sectional study utilised electronic data...
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Full-text available
Our aim was to develop a framework-based weight control behavior questionnaire (Weight-CuRB) and test its psychometric properties among a non-probability sample of 240 postmenopausal women with osteoporosis. Appropriate validity, simplicity, functionality and reliability were observed for the Weight-CuRB. The explanatory model fits the data well (χ...
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Objectives Traditionally, the approach to fracture prevention has focused on increasing bone mineral density while typically lacking a combined clinical approach to falls prevention and vice versa. To resolve this gap, we implemented and evaluated a novel combined model of care to the assessment and prevention of osteoporosis and falls in the outpa...
Chapter
There is a clear contribution made by biological anthropology to contemporary efforts to prevent osteoporosis and fracture and an imperative of understanding epigenetics to future risk identification and targeted pharmacological interventions. The three lines of evidence for the effect of socio-economic context on musculoskeletal health demonstrate...
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The identification of osteoporosis prior to fracture and effective postfracture care is imperative to public health. However, disparities exist in screening, diagnosis and treatment of osteoporosis between sexes, social groups and ethnicities. Indeed, the osteoporosis ‘care gap’, itself a worldwide phenomenon, is disproportionately experienced by s...
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Environmental factors begin to influence bone health in utero and continue across the life course, ultimately influencing our lifelong prospects of good bone health. These social-environmental forces are referred to as the Social Determinants of Health (SDoH) and result in the social patterning of health outcomes: a phenomenon referred to as the so...
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This chapter discusses two case studies using limb bone microstructure samples from a medieval (eleventh to sixteenth centuries) English skeletal collection in Canterbury. The site represents low and high socio-economic status (SES) groups. Firstly, the effect of SES on skeletal growth is investigated by combining dental indicators of childhood phy...
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Disparities exist in fracture incidence, prevalence, rates and risk factors between social and ethnic groups. Whilst genetic predisposition, such as sex and ethnicity, influence the risk of fractures, a significant contribution is made by environmental stressors. In addition to the direct effect of lifestyle behaviours and key risk factors for frac...
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Background: Residents of rural and regional areas, compared to those in urban regions, are more likely to experience geographical difficulties in accessing healthcare, particularly specialist services. We investigated associations between region of residence, socioeconomic status (SES) and utilisation of all-cause revision hip replacement or revis...