Shaoyuan Tan's research while affiliated with St. Jude Children's Research Hospital and other places

Publications (5)

Article
Full-text available
Little is known about the prevalence of avian influenza viruses (AIV) in wildlife and domestic animals in Polynesia. Here, we present the results of active AIV surveillance performed during two sampling seasons in 2019 on Easter Island (Rapa Nui). Tracheal and cloacal swabs as well as sera samples were obtained from domestic backyard poultry, while...
Article
Full-text available
Background Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown. Objective An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function. Methods Hi...
Article
Introduction: Chemotherapy for hematologic malignancies can cause severe cardiomyopathy. Chemotherapeutic agents also induce immune suppression increasing the risk of opportunistic infections. Hypothesis: We have hypothesized that immunosuppression after chemotherapy increases opportunistic viral infections, myocarditis and cardiomyopathy. Methods:...
Article
Background Human astroviruses (HAstV) are a leading cause of acute gastroenteritis in children, particularly those under the age of 2 or with immunosuppressive conditions. Indeed, our studies suggest that children with hematological malignancies are at high risk of infection. However, it has become increasingly clear that HAstV infections can also...
Article
Full-text available
Since the 1970s, eight closely related serotypes of classical human astroviruses (HAstV) have been associated with gastrointestinal illness worldwide. In the late 2000s, three genetically unique human astrovirus clades, VA1-VA3, VA2-VA4, and MLB, were described. While the exact disease associated with these clades remains to be defined, VA1 has bee...

Citations

... Unlike classical HAstVs, HAstV-VA1 has rarely been linked to diarrhea [43,44] but has been reported in association with neurological disease [31,45]. Classical and non-classical HAstVs are genetically distinct and differ on key factors of replication and pathogenesis [46,47]. Since the novel HAstV strain was discovered just over 10 years ago, investigations into its pathogenesis are just beginning and our finding that it does not induce EMT may reveal an underlying fundamental difference between it and classical HAstVs. ...