Shaolin Li's research while affiliated with Sun Yat-Sen University and other places

Publications (16)

Article
Full-text available
Background: The severe and critical cases of COVID-19 had high mortality rates. Clinical features, laboratory data, and radiological features provided important references for the assessment of COVID-19 severity. The machine learning analysis of clinico-radiological features, especially the quantitative computed tomography (CT) image analysis resu...
Article
Objective Meniscal degeneration is strongly associated with osteoarthritis (OA). We aimed to evaluate a 3D ultrashort-echo-time Cones magnetization transfer (UTE-Cones-MT) sequence for quantification of macromolecular fraction (MMF) and MT ratio (MTR) in menisci of healthy volunteers and patients with different degrees of OA. Methods Patients with...
Article
Full-text available
Background: Although lumbar bone marrow fat fraction (BMFF) has been demonstrated to be predictive of osteoporosis, its utility is limited by the requirement of manual segmentation. Additionally, quantitative features beyond simple BMFF average remain to be explored. In this study, we developed a fully automated radiomic pipeline using deep learni...
Preprint
Black-box nature hinders the deployment of many high-accuracy models in medical diagnosis. Putting one's life in the hands of models that medical researchers do not trust it's irresponsible. However, to understand the mechanism of a new virus, such as COVID-19, machine learning models may catch important symptoms that medical practitioners do not n...
Article
The osteochondral junction (OCJ) of the knee joint is comprised of multiple tissue components, including a portion of the deep layer cartilage, calcified cartilage, and subchondral bone. The OCJ is of increasing radiological interest as it may be relevant in the early pathogenesis of osteoarthritis (OA). Due to its short transverse relaxation, the...
Article
A b s t r a c t Purpose To develop and externally validate an MR-based radiomics nomogram from retrospective multicenter datasets for pretreatment prediction of early relapse (≤ 1 year) in osteosarcoma after surgical resection. Methods This multicenter study retrospectively enrolled 93 patients (training cohort: 62 patients from four hospitals; v...
Article
Full-text available
Background Infection with COVID-19 is currently rare in children.Objective To describe chest CT findings in children with COVID-19.Materials and methodsWe studied children at a large tertiary-care hospital in China, during the period from 28 January 2019 to 8 February 2020, who had positive reverse transcriptase polymerase chain reaction (RT-PCR) f...
Preprint
For diagnosis of COVID-19, a SARS-CoV-2 virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test is routinely used. However, this test can take up to two days to complete, serial testing may be required to rule out the possibility of false negative results, and there is currently a shortage of RT-PCR test kits, underscoring the...
Article
Aims Osteoporosis has been known to generally result from an imbalance between bone formation and resorption. Osteogenesis is the process of differentiation of mesenchymal stem cells (MSCs) into osteoblasts. Sirtuin6 (SIRT6) has been reported to mediate osteogenic differentiation (OD) in human bone MSCs (HBMSCs). The present study aimed to assess t...
Article
Full-text available
Objectives To explore the relationship between the imaging manifestations and clinical classification of COVID-19.Methods We conducted a retrospective single-center study on patients with COVID-19 from Jan. 18, 2020 to Feb. 7, 2020 in Zhuhai, China. Patients were divided into 3 types based on Chinese guideline: mild (patients with minimal symptoms...
Article
In this retrospective study, chest CTs of 121 symptomatic patients infected with coronavirus disease-19 (COVID-19) from four centers in China from January 18, 2020 to February 2, 2020 were reviewed for common CT findings in relationship to the time between symptom onset and the initial CT scan (i.e. early, 0-2 days (36 patients), intermediate 3-5 d...
Article
In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 Novel Coronavirus (2019-nCoV) were reviewed with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, sometime...
Article
Full-text available
The collagen density is not detected in the patellar tendon (PT), posterior cruciate ligament (PCL), and anterior cruciate ligament (ACL) in clinic. We assess the technical feasibility of three-dimension multiecho fat saturated ultrashort echo time cones (3D FS-UTE-Cones) acquisitions for single- and bicomponent T2 ⁎ analysis of bound and free wate...
Article
Repairing articular cartilage defects is difficult due to the hypovascular biostructure and poor self-repairing capacity of articular cartilage. Currently, mesenchymal stem cells (MSCs) with excellent differentiation potential are considered as a promising biological approach for cartilage regeneration. The effect, however, remains far from satisfa...
Article
Full-text available
The relationships between IVIM and DCE-MRI parameters in AS are not clear. We explore the correlation between intravoxel incoherent motion (IVIM) diffusion weighted imaging (DWI) and dynamic contrast-enhanced (DCE) parameters obtained on MR images in patients with ankylosing spondylitis (AS). Forty-four patients with AS were prospectively examined...

Citations

... The severity of COVID-19 depends on many physiological factors of which some are explainable in artificial intelligence (AI)-assisted severity classification. In a study by Liu et al. [15], 78 patients with COVID-19 were categorized as mild, regular, severe, and critical according to clinical conditions. Early triage of these patients could be supported by machine learning with CT-based clinical-radiological features. ...
... Decreased MMF and MTR were observed for cartilage and meniscus in mild and advanced OA as compared to healthy subjects. 93,94 UTE Quantitative Susceptibility Mapping Quantitative susceptibility mapping (QSM) has recently emerged as a promising technique that allows characterization of tissue based on its magnetic susceptibility. 95 QSM can estimate the spatial susceptibility distribution from a measured field perturbance using nonlinear optimization techniques. ...
... The purpose of cartilage imaging is to assess the completeness of cartilage tissue, cartilage thickness, and its relationship to subchondral bone. Ultrashort echo time (UTE) sequences represent a group of clinically compatible techniques that are capable of using echo times <1 ms [11] and has gained attention for the display of osteochondral junctions [10,[12][13][14][15][16][17][18]. Bae et al. imaged the isolated patella using the dual inversion prepared UTE sequence (DIR-UTE) and found a high signal at the osteochondral junction [12], which was not available on conventional sequences; by histological experiments, the source of the high signal at the osteochondral junction was found to be the deepest layer of the non-calcified and calcified cartilage. ...
... Previous models often used elaborate architectures as well as deeper hierarchies to improve their fitting ability and thus give them higher accuracy. While this approach can increase the model's accuracy to some extent, it tends to reduce the generalization ability of the model, and thus the effect of the improvement is on the weak side often [39,40]. Further, excessively sophisticated architecture will lead to slow and less efficient model training, and the hardware demands will likely be high. ...
... İterasyon başına işlenen örnek sayısı, önerilen modelin girdi görüntülerini eş zamanlı olarak seçilmiş değer kadar işlenmesini sağlar ve donanımsal özellikler ile doğrudan alakalıdır [27]. [11] çalışmasına göre avantajı uçtan uca bir yaklaşım önermesidir. Fakat deneysel analizlerin kuantum bilgisayarlar tarafından gerçekleştirilememesi ise bir dezavantaj olarak görülmüştür. ...
... Moreover, the interaction between miR-101-3p and PTGS2 has also been demonstrated in colon cancer, gastric cancer and esophageal squamous cell carcinoma but not in bone remodeling (Strillacci et al., 2009;Wang et al., 2010;Gong et al., 2016). In contrast, miR-186-5p and miRNA-93-5p were reported to be osteogenic differentiation inhibitors via various target genes (Zhang et al., 2017;Xu et al., 2019;Xiao et al., 2020;Li et al., 2021). Interestingly, it was reported that miR-451a induced osteoblast differentiation and mineralization in vitro and significantly reversed ovariectomy-induced bone loss in vivo (Karvande et al., 2018). ...
... After assigning each lung lobe with a score based on the degree of pneumonia, the total chest CT score is calculated as the sum of 5 lobe scores [1,[8][9][10][11]. Studies have showed that semi-quantitative chest CT scores were associated with categorized COVID-19 outcomes, and higher chest CT score was predictive of adverse outcomes [12][13][14][15]. ...
... [5] CRP in severe Covid -19patients increased significantly at the initial stage, and is a signal of lung deterioration and progression. [6] In this study, we examined the relationship between levels of inflammatory markers and CT severity score in patients with SARS-COV-2 pneumonia to prove whether or not there is a correlation between them, and thus to assess the role of CT versus biomarkers as a prognostic value for COVID-19 disease severity and short-term clinical outcome. ...
... CT manifestations of heavy/critical-type infection show consolidation of multiple lesions and interlobular septal thickening. In the paper [44], Bernheim et al. mentioned that the CT image features of COVID-19 are consolidative pulmonary opacities and bilateral and peripheral ground glass. The longer the onset of symptoms, the more findings on CT images. ...
... Two retrospective group of critically ill patients in Italy, reported a median PaO2/FiO2 was 160, with higher values in younger patients (164) than in older patients (156)" [28,29]. "Radiographic features of severe disease imaging modalities are clinically useful in revealing important findings linked to the development of the severe disease" [32]. in this study the classification of the severity of pulmonary engagement detected by X-ray or CT scan imaging was classified as previously described [21] and proved to be a good predictor of the outcome as reported in Figs. 2 and 5b, these results were in good accordance with data from literature [33,34]. ...