Shanna D Kulik's research while affiliated with Vrije Universiteit Amsterdam and other places

Publications (19)

Article
BACKGROUND Glioma is associated with pathologically high peritumoral neuronal activity, which associates with faster tumor progression. Concurrently, glioma patients have local and widespread disturbances of the functional brain network as measured with magnetoencephalography (MEG), such as higher network clustering (the extent to which regions con...
Article
BACKGROUND Many patients with glioma suffer from poorly understood executive functioning deficits before and/or after tumor resection. In the past decade, it has become increasingly clear that there is a complex interplay between glioma and both local and global functional activity and connectivity. Moreover, multilayer network integration of the f...
Article
Full-text available
Background Synaptic and neuronal loss contribute to network dysfunction and disability in multiple sclerosis (MS). However, it is unknown whether excitatory or inhibitory synapses and neurons are more vulnerable and how their losses impact network functioning. Objective To quantify excitatory and inhibitory synapses and neurons and to investigate...
Article
Full-text available
It is unclear why exactly gliomas show preferential occurrence in certain brain areas. Increased spiking activity around gliomas leads to faster tumour growth in animal models, while higher non-invasively measured brain activity is related to shorter survival in patients. However, it is unknown how regional intrinsic brain activity, as measured in...
Article
Background Glioma is associated with pathologically high neuronal activity around the tumor, which associates with faster tumor progression in patients. Concurrently, patients with glioma have local and widespread disturbances of the functional brain network as measured with magnetoencephalography (MEG) such as higher network clustering (the extent...
Preprint
Many patients with glioma, primary brain tumors, suffer from poorly understood executive functioning deficits before and/or after tumor resection. We aimed to test whether frontoparietal network centrality of multilayer networks, which allow for integration across multiple frequencies, relates to and predicts executive functioning in glioma patient...
Article
Full-text available
BackgroundA common problem in resting-state neuroimaging studies is that subjects become drowsy or fall asleep. Although this could drastically affect neurophysiological measurements, such as magnetoencephalography (MEG), its specific impact remains understudied. We aimed to systematically investigate how often drowsiness is present during resting-...
Preprint
Full-text available
Introduction Computational models are often used to assess how functional connectivity (FC) patterns emerge from neuronal population dynamics and anatomical connections in the brain. However, group averaged data is often used in this context and it remains unclear whether individual predictions of FC patterns using this approach can be made. Here,...
Preprint
Full-text available
It is unclear why exactly gliomas show preferential occurrence in certain brain areas. Increased spiking activity around gliomas leads to faster tumor growth in animal models, while higher non-invasively measured brain activity is related to shorter survival in patients. However, it is unknown how regional intrinsic brain activity, as measured in h...
Article
Full-text available
Multiple sclerosis (MS) features extensive connectivity changes, but how structural and functional connectivity relate, and whether this relation could be a useful biomarker for cognitive impairment in MS is unclear. This study included 79 MS patients and 40 healthy controls (HCs). Patients were classified as cognitively impaired (CI) or cognitivel...
Article
Full-text available
Background Impaired eye movements in multiple sclerosis (MS) are common and could represent a non-invasive and accurate measure of (dys)functioning of interconnected areas within the complex brain network. The aim of this study was to test whether altered saccadic eye movements are related to changes in functional connectivity (FC) in patients with...
Article
Full-text available
Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoenceph...
Article
Introduction: Glioma patients show increased global brain network clustering relating to poorer cognition and epilepsy. However, it is unclear whether this increase is spatially widespread, localized in the (peri)tumor region only, or decreases with distance from the tumor. Materials and methods: Weighted global and local brain network clusterin...
Preprint
Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoenceph...
Article
Full-text available
Background Cognitive decline remains difficult to predict as structural brain damage cannot fully explain the extensive heterogeneity found between MS patients. Objective To investigate whether functional brain network organization measured with magnetoencephalography (MEG) predicts cognitive decline in MS patients after 5 years and to explore its...
Article
Full-text available
IntroductionProgression-free survival (PFS) in glioma patients varies widely, even when stratifying for known predictors (i.e. age, molecular tumor subtype, presence of epilepsy, tumor grade and Karnofsky performance status). Neuronal activity has been shown to accelerate tumor growth in an animal model, suggesting that brain activity may be valuab...
Article
Introduction Functional brain networks in glioma patients are characterized by higher global clustering than healthy controls, indicating stronger connectivity in triads of brain regions when averaging across the entire brain. However, this could be due to either primary increased local clustering of (peri)tumor regions or higher local clustering t...
Article
Full-text available
Introduction Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly understood. An important marker for survival in these patients is isocitrate dehydrogenase (IDH) mutation (IDH‐mut). Patients with IDH‐mut glioma have a better prognosis but more often suffer from epilepsy than patients with IDH‐wildtype (IDH‐wt) glioma,...
Article
Background Isocitrate dehydrogenase (IDH) mutation (IDH-mut) is an important marker for survival in diffuse glioma patients. Patients with an IDH-mut glioma have a better prognosis but more often suffer from epilepsy. Patients with a wildtype glioma (IDH-wt) are generally older and more often have cognitive deficits. Regardless of IDH status, cogni...

Citations

... Additionally, it will be important to monitor subclinical neuronal hyperexcitability as this might still affect glioma growth which will require further examination via longitudinal monitoring via EEG and MEG [38]. Additionally, it has been recently reported that gliomas occur more often in brain regions with higher activity [79]. ...
... This Focus Feature also provides and evaluates new network-based biomarkers. Kulik and colleagues (Kulik et al., 2022) explore associations between structural and functional connectivity in a cohort of multiple sclerosis (MS) patients, and investigate whether (alterations in) this relation could be a useful biomarker for cognitive impairment in MS. Although there were significant differences in structure-function coupling between cognitively impaired patients and matched healthy controls, receiver operating characteristic (ROC) curves revealed that these group-level differences did not significantly differentiate between groups. ...
... Impaired saccadic eye movements were related to the functional connectivity of the oculomotor network and clinical performance in MS in [49]. The authors measured the eye movements using Eyelink 1000 Plus. ...
... 2 Similar results have also been observed when using broadband power measured non-invasively with magnetoencephalography (MEG) and EEG as a proxy of neuronal activity. 8 Furthermore, there are indications that healthy and pathological activity in the (peri)tumoural region are interdigitated during cognitive performance in these patients. 9 This complex bidirectional interaction between the brain and glioma that informs both tumour and patient behaviour has sparked the relatively new field of 'cancer neuroscience', aiming to explain how this crosstalk may inform understanding and treatment of glioma. ...
... Nevertheless, mean FSIQ and GM values were within normal limits (FSIQ ranged from 86.62 to 115.66 and GM 87.7 to 119.96) 29,30 , and no patients were under the cutoff point of AQ (93.8) 25 . GM and verbal memory scores showed strong negative correlations with the LPS value between raPFC and lSPL in the beta1 band (13)(14)(15)(16)(17)(18)(19)(20). Patients with left frontal gliomas have often shown some language function impairment 1 . ...
... As it turns out, several time-varying connectivity parameters are hierarchically organized in the normal connectome (Lurie et al., 2020;Vidaurre et al., 2017). Even in the absence of an explicit task the functional network transitions between distinct states in a non-random order (Vidaurre et al., 2017;Zalesky et al., 2014), which are identified by observing recurrent network conformations (Miller et al., 2016). This new way of analyzing an order of events within a functional scan could reveal how the functional network dynamically moves between and behaves within states, which might be essential for understanding dynamic network integration and hence cognition in MS. ...
... These data were processed as previously described. [35][36][37] In short, data were visually inspected and at maximum 12 malfunctioning channels were excluded. Offline spatial filtering of the raw data removed artefacts using the temporal extension of Signal Space Separation (tSSS) using MaxFilter software (Elekta Neuromag Oy; v.2.1). ...
... Likewise, better functional connectivity being associated with better neurocognitive performance has been observed in patients suffering from gliomas with IDH mutation compared to patients with IDH wildtype gliomas, although functional neuronal networks have been shown to be more often invaded by gliomas with IDH mutation than IDH wildtype glioma (Derks et al. 2019). This may suggest a relation of cellular rate of growth to molecular mechanisms of glioma cell integration along axonal projections or specific interactions with neuronal networks, both posing major limitations to maximize extent of tumor resection . ...
... Another study by Kessler and colleagues employed a flexible battery of cognitive measures based on clinical needs prior to initial surgery and found that incidence of cognitive impairment defined as zscore of ≤ − 1.5 on two tests or ≤ −2.0 on one test was significantly higher in patients with IDH1-WT gliomas when compared with that in patients with IDH1-mut gliomas (84% vs. 65%, respectively) [30••]. Derks and colleagues used a battery of cognitive tests measuring verbal memory, executive functioning and psychomotor speed, working memory, information processing speed and psychomotor speed, attention functioning, and executive functioning in 54 diffuse grade II-IV glioma patients prior to initial surgery [38]. They found that IDH1-WT glioma patients performed worse on cognitive testing relative to patients with IDH-Mut gliomas; however, only difference in the summary score of a verbal memory test reached statistical significance after adjusting for age, presence of epilepsy, and education. ...