Shang Wan's research while affiliated with Sichuan University and other places

Publications (20)

Article
Full-text available
Background We aimed to assess whether the quantitative parameters of esophageal varices (EV) based on computed tomography (CT) can noninvasively predict severe EV and the risk of esophageal variceal bleeding (EVB). Methods A total of 136 endoscopically confirmed EV patients were included in this retrospective study and were divided into a non-cons...
Article
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Background Clear cell Renal Cell Carcinoma (ccRCC) is the most common malignant tumor in the urinary system and the predominant subtype of malignant renal tumors with high mortality. Biopsy is the main examination to determine ccRCC grade, but it can lead to unavoidable complications and sampling bias. Therefore, non-invasive technology (e.g., CT e...
Article
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With the development of heteronuclear fluorine, sodium, phosphorus, and other probes and imaging technologies as well as the optimization of magnetic resonance imaging (MRI) equipment and sequences, multi-nuclear magnetic resonance (multi-NMR) has enabled localize molecular activities in vivo that are central to a variety of diseases, including car...
Article
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Objective Clinical evidence suggests that the risk stratification of portal hypertension (PH) plays a vital role in disease progression and patient outcomes. However, the gold standard for stratifying PH [portal vein pressure (PVP) measurement] is invasive and therefore not suitable for routine clinical practice. This study is aimed to stratify PH...
Article
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Objective Early detection and diagnosis of hepatocellular carcinoma (HCC) is essential for prognosis; however, the imaging hallmarks for tumor detection and diagnosis has remained the same for years despite the use of many new immerging imaging methods. This study aimed to evaluate the detection performance of hepatic nodules in high risk patients...
Article
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Background: Mutation screening for gastrointestinal stromal tumor (GIST) is crucial and the c kit gene (KIT) exon 11 mutation is the most common type. This study aimed to explore the associations between GIST with KIT exon 11 mutation and contrast-enhanced computed tomography (CT) images. Methods: Pathologically proven GISTs with definitive geno...
Chapter
Portal hypertension is one of the major complications in patients with chronic liver diseases (CLD) which induces the increase in portal vein gradient pressure. At advanced stage, it can cause the esophageal varices and variceal hemorrhage. Therefore, portal hypertension has been the leading cause of mortality in CLD patients. To diagnose portal hy...
Article
Purpose To assess whether CT (computed tomography)-derived quantitative parameters of liver lobe volume can predict severe esophageal varices (EV) and the risk of first variceal hemorrhage (FVH) in patients with liver cirrhosis. Methods A total of 217 endoscopically confirmed EV patients were included in this retrospective study and were divided i...
Article
Full-text available
Adrenal lymphangioma is a very rare benign lesion worldwide and remains challenging for early diagnosis, especially when the patient has some complicated clinical disease. This is an unusual case of a 68-year-old man who was admitted to our hospital with a history of pancreatic tumor. Computed tomography (CT) images and subsequent magnetic resonanc...
Article
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Purpose: To determine whether morphologic features and semiquantitative parameters of computed tomography (CT) could be used to distinguish heterotopic pancreas from gastrointestinal stromal tumor (GIST) and leiomyoma. Methods: This retrospective study evaluated CT images of heterotopic pancreases (n = 28), GISTs (n = 57), and leiomyomas (n = 26...
Article
Full-text available
The most common mesenchymal tumors are gastrointestinal stromal tumors (GISTs), which have malignant potential and can occur anywhere along the gastrointestinal system. Imaging methods are important and indispensable of GISTs in diagnosis, risk staging, therapy, and follow-up. The recommended imaging method for staging and follow-up is computed tom...
Article
Background: The coronavirus disease 2019 (COVID-19) has rapidly become a pandemic worldwide. The value of chest computed tomography (CT) is debatable during the treatment of COVID-19 patients. Compared with traditional chest X-ray radiography, quantitative CT may supply more information, but its value on COVID-19 patients was still not proven. Me...
Article
Rationale and objectives: We aimed to assess the prevalence of significant computed tomographic(CT) manifestations and describe some notable features based on chest CT images, as well as the main clinical features of patients with coronavirus disease 2019(COVID-19). Materials and methods: A systematic literature search of PubMed, EMBASE, the Cochra...
Article
Full-text available
Background: To prospectively establish and validate new diagnostic criterion (DC) for liver-specific contrast agents and further compared the diagnostic sensitivity and specificity with conventional DC. Methods: Institutional Review Board approved and written informed consent were obtained for this prospective study. Two board-certified reviewers e...
Article
Background: To explore whether a multiparametric radiomics nomogram on computed tomography (CT) images based on radiomics and relevant parameters of esophageal varices (EV) can be used for predicting the EV severity in patients with cirrhotic livers. Methods: From January 2016 to August 2018, 136 consecutive patients with clinicopathologically c...
Article
Rationale and objectives: The aim of our study is to evaluate the severity of esophageal varices (EV), based on the computed tomographic portography (CTP) measurement of EV in the distal esophagus and to assess the prediction value of EV volume. Patients and methods: A total of 53 EV patients examined by CTP within 4 weeks of upper endoscopy wer...

Citations

... In this technique, circularly polarized light is used to selectively optically pump (usually) rubidium (Rb) electrons, generating a highly spin-polarized Rb gas. A wide range of nuclei 2 H, 3 He, 13 C, 15 N, 31 P, and 129 Xe can be polarized [50]. The 129 Xe hyperpolarization method can be used for lung imaging amongst others [51]. ...
... In summary, the ML algorithm could identify fibrous matrix features and correlate with HVPG measurements. In addition to morphology-based features, texture features and deep convolutional neural network-based imaging analysis also showed a potential performance in assessing PH (28,57). However, due to the end-to-end nature of the model, specific features that helped improve diagnostic performance could not be elucidated. ...
... Esophageal varices (EV), which are dangerously prone to bleeding and have a high mortality rate due to portal hypertension, are serious issue in patients with liver cirrhosis. Sixty to eighty percent of newly diagnosed cirrhotic patients have EV, and 5% to 15% of those who have large EV experience their first variceal bleeding within a year [1]. As a result, Esophagogastroduodenoscopy (EGD) is necessary to detect EV in patients with cirrhosis at the time of diagnosis. ...
... Three studies developed a model or nomogram based on radiomic features obtained from CE-CT imaging (arterial, venous and delayed phase) to predict the presence of KIT exon 11 mutations, which resulted in varying AUC outcomes, namely 0.57, 0.72 and 0.81 [75,76,81]. Deletions in exon 11 may indicate more aggressive tumor behavior, and for this reason, Liu et al. also assessed the efficacy of their model in predicting exon 11 deletion affecting codons 557-558 and achieved an AUC of 0.85 [76]. ...
... Despite the crucial role of PVP or HVPG measurements for the assessment and prognostic evaluation of PH (11), the invasive nature and high-cost effectiveness of these techniques have limited their clinical application as ideal surveillance tools for monitoring disease progression (12). Currently, liver stiffness (LS) by transient elastography (TE; Fibro-Scan) is recognized as the backbone of the non-invasive diagnosis of PH (1,13); however, controversy still exists regarding its application in patients with obesity, non-alcoholic fatty liver disease, or severe Abbreviations: PH, portal hypertension; PVP, portal vein pressure; HVPG, hepatic venous pressure gradient; CSPH, clinically significant portal hypertension; HE, hepatic encephalopathy; HCC, hepatocellular carcinoma; LS, liver stiffness; TE, transient elastography; CT, computed tomography; TIPS, transjugular intrahepatic portosystemic shunt; PFS, progression-free survival; FHVP, free hepatic venous pressure; WHVP, wedged hepatic venous pressure; ROIs, regions of interest; GLCM, gray-level cooccurrence matrix; GLSZM, gray-level size zone matrix; GLRLM, gray-level run length matrix; NGTDM, neighboring graytone difference matrix; GLDM, gray-level dependence matrix; ICC, intraclass correlation coefficient; ROC, receiver operating characteristic; AUC, curve and the area under the curve; INR, international normalized ratio; OR, odds ratio; SD, standard deviation; IQR, interquartile range; HR, hazard ratio; PT, prothrombin time; CTP, Child-Turcotte-Pugh. ascites (1). ...
... GHP often presents as an intramural oval mass with indistinct margins on CT coronal images [23,30]. GHP is usually small in diameter (often less than 3 cm) and tends to be an intraluminal growth pattern [6,14,31,32]. The CT attenuation, enhancement heterogeneity, and enhancement degree of GHP correlate with its pathological histological compositions [5,9,10,14,23,33]. ...
... Bilateral ground-glass opacities with peripheral localization have been reported as the typical CT findings, especially in the initial stages of the disease [7,8]. Quantitative analysis of CT scan has demonstrated promising results in the prognosis prediction, using segmentation algorithms and extraction of lung volumes according to Hounsfield Unit (HU) intervals [9][10][11][12]. ...
... This alternative method of detection is especially useful in the case of an ambiguous or false-negative RT-PCR result and help validate true-positive results, demonstrated by a study that found 5 of 167 patients with positive chest CT and negative RT-PCR results test positive for COVID-19 days later [6]. According to meta-analyses, COVID-19 on chest CT commonly presents with ground glass opacities in 86% of cases, consolidation in 47 % of cases, and air bronchogram sign in 46 % of cases [7]. By identifying these common patterns and being cognizant of new and potentially coronavirusspecific signs, we hope to add another crucial layer of testing to the diagnostic process of COVID-19. ...
... However, in some benign lesions, such as atypical hemangioma, it can also present with the typical enhancement pattern of APHE (35). This study did not conduct further analysis of the APHE subtypes, but Cunha's study (36) showed that there are still differences in observers' perceptions of APHE subtypes (37), and no unified understanding has been formed. Quantitative assessment can directly reflect histological features. ...
... GEVs were graded based on their form and the presence of RC marks and spots as follows: grade 0, no varices; grade 1 (mild GEVs), F1RC0 GEVs; grade 2 (moderate GEVs), F1RC1-3 or F2RC0 GEVs; and grade 3 (severe GEVs), F2RC1-3, F3RC0, or F3RC1-3 GEVs. This grading system has been described previously [19]. ...