Seniha Başaran's research while affiliated with Istanbul University and other places

Publications (50)

Article
Purpose While the definitive diagnosis of COVID-19 relies on PCR confirmation of the virus, the sensitivity of this technique is limited. The clinicians had to go on with the clinical diagnosis of COVID-19 in selected cases. We aimed to compare PCR-positive and PCR-negative patients diagnosed as COVID-19 with a specific focus on older adults. Meth...
Article
Objectives: We aimed to compare classical methods and chromogenic media to detect carbapenem-resistant Enterobacteriaceae (CRE) colonization among hospitalized patients and determine the risk factors causing infection in colonized patients. Methods: Between January and August 2017, 100 patients over the age of 18 who were hospitalized in the Reanim...
Article
Background While there are substantial reports on the acute phase of Covid-19, the data on post-Covid phase are limited. Aim To report the data on older post-Covid patients comparatively with the young adults. Study design Retrospective, single-center study in post-Covid outpatient clinic. Clinical characteristics, laboratory examination, chest i...
Article
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Background: The authors aimed to determine the efficacy of frequently used antibiotics, alone or in combination, against biofilms of ventilator-associated pneumonia isolates. Materials & methods: The authors determined the MICs, minimum biofilm inhibitory concentrations and minimum biofilm eradication concentrations of meropenem, ciprofloxacin and...
Article
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COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 patients who were either fu...
Article
Introduction: The authors aimed to investigate the biofilm-forming features of panresistant Klebsiella pneumoniae (PRKp). Material & methods: The biofilm formations were shown under light microscope and laser scanning confocal microscopy. The optical densities of the wells were measured and classified according to biofilm-forming capacities. Result...
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Introduction: It was aimed to evaluate the risk factors for the development of ventilator-associated pneumonia (VAP) and clinical outcomes and prognostic predictors of VAP. Materials and Methods: This retrospective and single-center study included patients aged ≥18 years who were diagnosed with VAP in the ICU. Patients were divided into two groups...
Preprint
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Purpose COVID-19 vaccines have been shown to be highly effective; however, vaccine breakthrough infections resulting from hospitalization may still occur in a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features and outcomes were different between hospitalized COVID-19 vaccinated and unvaccin...
Article
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Q fever is a zoonosis caused by Coxiella burnetii. In this report, a case of chronic Q fever endocarditis with pancytopenia and hypergammaglobulinemia mimicking a lymphoproliferative disease was presented. A 39-years-old male living in Çatalca and whose family is engaged in animal husbandry admitted with the complaints of weakness and fatigue. The...
Article
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Background: The prognostic factors for COVID-19 in patients with chronic kidney disease (CKD) are uncertain. We conducted a study to compare clinical and prognostic features between hospitalized COVID-19 patients with and without CKD. Methods: Fifty-six patients with stage 3-5 CKD and propensity score-matched fifty-six patients without CKD were...
Article
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ZET Amaç: Kafa tabanı osteomyeliti (KTO) nadir görülen, ancak hayatı tehdit eden ciddi bir infeksiyondur. Bu çalışmada çoğu komplike KTO hastalarının tanısı, tedavisi ve uzun dönem sonuçlarının infeksiyon hastalıkları ve klinik mikro-biyoloji (İHKM) bakış açısıyla irdelenmesi amaçlandı. Yöntemler: 2012-2019 yılları arasında kliniğimizde yatarak ted...
Article
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Objectives Disease severity, previous medications, immunosuppresive agents could affect the antibody response against SARS-CoV-2. We aimed to analyze variables affecting the humoral response to SARS-CoV-2. Methods In this prospective cohort study, we included adult patients who recovered from COVID-19 and were admitted to COVID-19 follow-up unit....
Conference Paper
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Background: The prognostic factors for COVID-19 in patients with chronic kidney disease (CKD) are uncertain. We conducted a propensity score-matched study to compare clinical and prognostic features between hospitalized COVID-19 patients with and without CKD. Methods: Patients with estimated creatinine clearance below 60 ml/min/1.73 m2 for more tha...
Article
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Syphilis has become a serious issue for human immunodeficiency virus (HIV)-infected patients worldwide in recent years; however, the studies related to HIV coinfection and syphilis reinfections in Istanbul, Turkey, are limited. Our objective was to determine the seroprevalence of syphilis among HIV-infected men in the city which has one of the high...
Article
Infective endocarditis (IE) is rare, but associated with significant morbidity and mortality rates. Estimates of the incidence of IE in Turkey are compromised by the absence of population-based prospective studies. Due to the frequent presence of predisposing cardiac conditions and higher rates of nosocomial bacteremia in highrisk groups, the incid...
Article
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Although infective endocarditis (IE) is rare, it is still important as an infectious disease because of the resulting morbidity and substantial mortality rates. Epidemiological studies in developed countries have shown that the incidence of IE has been approximately6/100 000 in recent years and it is on the fourth rank among the most life-threateni...
Article
Non-typhoidal salmonella (NTS) are food-borne pathogens resulting in self-limiting acute gastroenteritis, but also more severe, invasive and sometimes recurrent bacteremia with atypical organ involvement in immunocompromised adults, particularly with human immunodeficiency virus (HIV) infection. Here we present a case of acute hepatitis and pancyto...
Article
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Objective: Recommended combination for the treatment of serious Stenotrophomonas maltophilia infections is ticarcillin-clavulanate and co-trimoxazole (SXT). However, first agent is not available in our country, and the second component may be a matter of antimicrobial resistance or intolerance. Therefore, we aimed to evaluate antimicrobial suscepti...
Article
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Encephalitis is an inflammatory process involving the brain parenchyma associated with neurologic dysfunction. The main causes of infectious encephalitis are viruses, including Herpes simplex virus type 1 (HSV-1). As the mortality rate of HSV-1 encephalitis could be reduced with early acyclovir treatment, it is imperative to distinguish HSV-1 encep...
Article
Objective: We aimed to evaluate the patient factors which increase the probability of achieving a positive blood culture, distribution of microorganisms grown, and to reveal the impact of various factors during collection of blood on blood culture positivity. Methods: Blood cultures of patients with a body temperature of ≥38°C and compatible with a...
Article
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Objective: In this study, we aimed to determine the demographic and clinical characteristics of HIV-positive patients seen in our faculty; and to put forward the differences in virological response, immunological response and adverse effects of administered antiretroviral therapy (ART) regimens in these patients. Methods: Medical records of 175 HIV...
Article
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Objective: We aimed to find the incidence and risk factors of hematologic adverse effects of piperacillin-tazobactam (TZP). Materials and methods: Adult patients who used TZP for more than 10 days were included in the study. Results: The incidence of leukopenia, neutropenia, and eosinophilia in 110 TZP therapy episodes was found to be 16.3%, 1...
Article
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Objectives: We describe the molecular characteristics of colistin resistance and its impact on patient mortality. Methods: A prospective cohort study was performed in seven different Turkish hospitals. The genotype of each isolate was determined by MLST and repetitive extragenic palindromic PCR (rep-PCR). Alterations in mgrB were detected by seq...
Article
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Objective: Plasmodium falciparum acquired abroad, has become the main causative malaria agent in Turkey due to the elimination of endemic P. vivax in recent years. By describing clinical, laboratory and treatment features of imported malaria cases caused by P. falciparum, we aimed to distinguish it from other infectious diseases with similar epidem...
Article
We describe the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infections in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter bau...
Article
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Coccidioidomycosis caused by Coccidioides immitis or Coccidioides posadasii is a rare infectious disease except in endemic regions. In this report the third documented imported case of coccidioidomycosis in Turkey was presented. A thirty-year-old male patient was admitted to our hospital with fever and purulent drainage from his chest tube. He had...
Article
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We described the prevalence of antibiotic resistance and predictors of fatality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause fatality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae w...
Article
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Sepsis is defined as development of probable or proved infection accompanied by systemic signs of infection. It is estimated that incidence of severe sepsis in United State of America was 300 people in 100 000. The half of these patients was out of intensive careunit. The one-fourth of patients with severe sepsis hasbeen dying duringtheir hospitali...
Article
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Sepsis, severe sepsis, and septic shock are medical clinical emergencies. Despite intensive effort, including a lot of clinical trials, optimal therapy has changed little since the 1960s. Early clinical suspicion and rigorous diagnostic measures are important in sepsis treatment. Three elements are the basic components of therapy for septic shock:...
Article
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Objective: The aim of this study is to compare the efficacy of catheter lock solutions of novel antibiotics with anticoagulants against methicillin-resistant Staphylococcus aureus (MRSA) embedded in biofilm. Methods: Biofilm was formed in vitro on silicone Hickman catheter segments by 10 MRSA isolates. Catheter segments were exposed to 2 mg/ml vanc...
Article
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A case of infective endocarditis (IE) presented with fatigue, lowgrade fever, painful nodular lesions and intracranial haemorrhage and diagnosed after 16 months is reported. A 35-year-old woman without any previous disease was investigated at different medical departments during these 16 months. Despite the detection of an underlying valvular heart...
Article
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Objective: It was aimed to evaluate clinical and laboratory differences and characteristic aspects between cases that were classified in three subgroups as tuberculous spondylodiscitis (TS), pyogenic spondylodiscitis (PS) and brucellar spondylodiscitis (BS). Methods: Adult patients with spondylodiscitis diagnosis were evaluated retrospectively. Pat...
Article
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Rothia mucilaginosa, previously known as Stomatococcus mucilaginosus, is a Gram-positive coccus and belongs to the family Micrococcaceae. It is considered as normal flora of oropharynx and upper respiratory tract, and rarely causes pneumonia. In this report, we present a case of nosocomial pneumonia caused by R. mucilaginosa, in a patient who recen...
Article
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Objective: The aim of this study is to evaluate nosocomial infections (NIs) in intensive care unit (ICU) in terms of site of infection, distribution of pathogens and risk factors for developing infection. Methods: 80 patients staying for more than 48 hours in the ICU were included in the study. Epidemiologic characteristics of the patients, invasiv...
Article
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Objective: It was aimed to evaluate clinical and laboratory differences and characteristic aspects between cases that were classified in three subgroups as tuberculous spondylodiscitis (TS), pyo-genic spondylodiscitis (PS) and brucellar spondylodiscitis (BS). Methods: Adult patients with spondylodiscitis diagnosis were evaluated retrospectively. Pa...
Article
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Nosocomial infections caused by multidrug-resistant (MDR) microorganisms are a major problem in intensive care units (ICUs) with high mortality and morbidity rates and the prior colonization is an important risk factor for these infections. The aim of this study was to investigate the prevalence of rectal colonization of MDR microorganisms and the...
Article
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Actinomyces species may lead to slowly progressive infection of almost any site once mucosal breakdown exists; hence, it has the name "great pretender." Its diagnosis may be unthinkable unless proper cultures/histologies are taken. We describe a patient with lumbar spondylodiscitis and epidural abscess. This is an exceptional another disease by act...
Article
The aim of this study was to determine the in vitro activities of doripenem, imipenem, and meropenem against clinical gram-negative isolates. A total of 596 clinical isolates were obtained from intensive care unit (ICU) and non-ICU patients in 10 centers over Turkey between September-December 2008. The origin of the isolates was patients with nosoc...
Article
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Amaç: Nötropenik hastalarda infeksiyonların uygun ve hızlı bir şe-kilde tedavi edilmesi morbidite ve mortaliteyi etkilemektedir. Etken-lerin sıklığını bilmek büyük önem taşımaktadır. Bu çalışmada hema-tolojik malignitesi olan hastaların febril nötropeni atağı sırasında kan kültürü (KK)'nde üreyen etkenlerin dağılımı, direnç durumu ve hastaların kli...
Article
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Crimean-Congo haemorrhagic fever (CCHF) is a severe disease with a case fatality of 2.8 to 80 %. A patient dwelling in an endemic region for CCHF was admitted with fever preceding bleeding diathesis and pancytopenia. Despite no history of tick exposure, CCHF was highly suspected. With an oral ribavirin therapy, clinical and laboratory improvements...

Citations

... In a two-center joint study, the biofilm-forming capacity of K. pneumoniae strains was on average 93.6%; however, that of respiratory tract strains was 100% [31]. Also, Tuncer et al. found that the biofilm formation rate was 100% in K. pneumoniae isolates as invasive infection agents [32]. In another study, the biofilm-forming potentials of P. aeruginosa, K. pneumoniae and A. baumannii isolates from burned tissues were 73.8%, 71% and 40%, respectively [33][34][35][36][37]. Partly similar to those investigations, the present study showed that most of the VAP Pseudomonas spp., K. pneumoniae and A. baumannii isolates had in vitro biofilm-forming abilities (63.6%, 94% and 100%, respectively). ...
... 8,9 In addition, excessive IL-6 levels could contribute to lymphocytopenia, 10 a striking feature of full-blown COVID-19. 1 Published data on the effects of therapeutic use of IL-6 blockade on the immune response against SARS-CoV-2 are scarce and restricted to early stages after therapy. [11][12][13] Whilst we found that the use of anti-IL-6 agents did not affect the initial antibody response against SARS-CoV-2, 11 significant reductions in neutralizing activity of anti-SARS-CoV-2 antibodies have recently been reported in a small group of patients treated with anti-IL-6 receptor monoclonal antibodies, raising concerns on the risk of reinfection and suboptimal response to vaccination in patients treated with anti-IL-6 agents. 13 Long-term data on host immune response to SARS-CoV-2 and clinical outcome of patients recovered from COVID-19 after treatment with IL-6 inhibitors are crucial to understand the potential impact of this therapy on the protective immunity against SARS-CoV-2 and might provide insight into the role of this cytokine during viral infections. ...
... Colistin is a last-resort antibiotic for these infections (Fritzenwanker et al., 2018). However, colistin resistance has also emerged following its usage in difficult to treat infections caused by carbapenemand multidrug-resistant K. pneumoniae including the ST101 high-risk clone, leaving almost no alternative treatment options and also leading to the dissemination of colistin resistance (Can et al., 2018). ...
... By the end of 2019, there had been 962,809 people living with HIV (PLWH) in China, and male-to-male sexual contact had become one of the main routes of HIV transmission (23.3%) (3). In addition to HIV, MSM, including HIV-positive ones, were disproportionally affected by sexually transmitted diseases (STD), especially syphilis (4). ...
... The incidence of IE is approximately 6/100,000 placing them in fourth place among the most life-threatening infectious diseases after sepsis, pneumonia, and intraabdominal infections [1]. The mean age of patients is 64 years and the most common clinical symptoms and signs are shortness of breath, cardiac murmur, and fever [2]. ...
... S. aureus'a bağlı KDE olan hastalarda ileri yaş, CKİ'nin yüksek olması, septik şok varlığının mortalite riskini arttırdığı bir diğer çalışmada gösterilmiştir [4] . Yine S. aureus bakteriyemilerinde mortalite için risk faktörlerinin araştırıldığı bir çalışmada yoğun bakımda yatış, CKİ skorunun yüksek olması ve metastatik odak varlığı mortalite için bağımsız risk faktörleri olarak bulunmuş [13] . Bizim çalışmamızda da literatürle benzer olarak ileri yaş, yoğun bakım ünitesinde yatış, CKİ skoru yüksekliği ve komorbidite sayısının fazla olması ölen hastalarda sağ kalan hastalara göre istatistiksel olarak anlamlı düzeyde farklı bulunmuştur. ...
... Other viral infections associated with hyponatremia include human herpesvirus-6 (HHV-6), SFTS virus (SFTSV), hantavirus, herpes simplex virus (HSV), and Ebola virus infections [34][35][36][37][38][39][40]. ...