Scott H. Sicherer’s research while affiliated with Icahn School of Medicine at Mount Sinai and other places

... Open OFCs were performed following PRACTALL recommendations. 12,13 All included food challenges were performed to either confirm or exclude a possible food allergy in patients having presented a previous clinical reaction possibly due to the tested food or put on an elimination diet based on the results of a previous allergy work-up. All those who presented a history of anaphylaxis had a prescription for Adrenaline Auto-Injector (AAI) and patients and/or caregivers are required to present with their emergency kit (including AAI) the day of the OFC. ...

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Anaphylaxis severity grade, during oral food challenges, assessed by five different classifications

... Puede haber anafilaxia por mecanismos mediados por IgE. [8][9][10][11][12][13][14][15][16][17][18][19] Se han reportado casos de enfermedad del suero por la formación de inmunocomplejos, debido a la producción de anticuerpos contra omalizumab con mecanismos de hipersensibilidad tipo III. Los pacientes pueden padecer fiebre, artralgias, eritema y linfadenopatía. ...

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Artículo de revisión Reacciones adversas por anticuerpos monoclonales en el tratamiento de enfer- medades alérgicas. Posicionamiento de Grupo: Comité de Alergia a Medicamen- tos del Colegio Mexicano de Inmunología Clínica y Alergia (CMICA 2024-2025) Adverse reactions due to monoclonal antibodies in the treatment of allergic diseases. Group Positioning: Comité de Alergia a Medicamentos del Colegio Mexicano de Inmunología Clínica y Alergia (CMICA 2024-2025)

... We also performed similar experiments assessing IgE + GC B cells. We cultured single GC B cells (sorted as B220 + GL7 + CD38 − IgD − IgG − ) with feeder cells along with IL-4, IL-2 and IL-10 (enhancing IgE B cell survival 23 ; Fig. 5h). We found that ~25% of GC B clones were IgE + in control mice. ...

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Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses

... Another area of research is the application for omalizumab beyond its current indications. A promising recent trial has demonstrated utility for omalizumab in treating food allergies, specifically in preventing allergic reactions to accidentally exposed food allergens, but future studies will need to validate those findings [58][59][60]. Evidence is growing that IgE could be involved in autoimmune diseases such as in bullous pemphigoid (BP) or systemic lupus erythematosus (SLE), which has sparked the evaluation of omalizumab in those conditions [61][62][63]. ...

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A Comparison of Natural and Therapeutic Anti-IgE Antibodies

... Specifically, saliva and stool ASVs that were identified as threshold-associated microbiota, peripheral blood levels for transcripts in the threshold-associated FcγR-mediated phagocytosis and TLR signaling co-expression modules, abundances for the cell type associated with reaction threshold (i.e., neutrophils), and peanut-specific serum IgE and Ara h 2 antibodies were used in these correlation analyses. As context, we previously found that among all co-expression modules identified by weighted gene coexpression network analysis [29] and Gene ontology (GO) analysis [30] of peripheral blood transcriptome data in this cohort, the FcγR-mediated phagocytosis and TLR signaling modules were specifically associated with reaction threshold [31]. In addition, among all peripheral blood cell types identified by whole blood staining and cytometry in this cohort, only neutrophils were associated with reaction threshold [31]. ...

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Oral and Gut Microbial Hubs Associated With Reaction Threshold Interact With Circulating Immune Factors in Peanut Allergy

... Food allergy represents an increasingly prevalent immune disease with potential lifethreatening implications, and is the result of a defect in the existing tolerance [183,184]. Oral tolerance (OT) to food proteins is a natural immune process in which the immune system recognizes common antigens as harmless [185]. When this mechanism does not work correctly, the harmless compound is recognized as a menace for the body and is attacked by the immune system, triggering an adverse immunological reaction as displayed in Figure 2. The gastrointestinal tract contains lymphocytes, as well as unique antigen-presenting cells with specialized functions. ...

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Unraveling the Biological Properties of Whey Peptides and Their Role as Emerging Therapeutics in Immune Tolerance

... 5 The significance of SA is underscored by its ranking as the third most common immunoglobulin E (IgE)-mediated FA among Israeli children, 6 and the fourth among Australian 7 and Turkish children. 8 Documented fatalities highlight the severity of SA, 9 with strict avoidance remaining the primary management approach, while oral immunotherapy (OIT) shows emerging promise. 10 Exciting data suggests that early introduction of OIT may lead to allergy resolution. ...

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Natural history of sesame allergy in pediatric patients: Insight from a retrospective analysis

... The most common allergens in acute FPIES include cow's milk, soy, eggs, fish, and cereals [11,12]. However, with recent guidelines endorsing the early introduction of peanuts in early infancy, there has been an increase in peanut-induced FPIES [13]. ...

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A Review of Non-IgE Immune-Mediated Allergic Disorders of the Gastrointestinal Tract

... More specifically, non-IgE mediated conditions are now classed under Type IVb T2 immune responses and type V tissue-driven, which are cell-mediated reactions that involve Tlymphocytes, eosinophils, a variety of cytokines, and in some conditions include epithelial barrier defects and leaky junctions. 1 The Figure 1). [2][3][4] Typically, non-IgE mediated reactions are delayed, with the onset of symptoms occurring several hours and even up to several days after exposure to a culprit food, with the exception of FPIES. ...

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An update on the diagnosis and management of non‐IgE‐mediated food allergies in children

... In the case of early sensitization to hazelnut, IgE from a majority of infants, under 1 year of age, with atopic dermatitis bound to the glycinin Cor a 9 [10]. Individuals with allergy to pistachio and cashew have been shown to have reactions to citrus seeds and pectins due to cross-reactivity of citrin, a glycinin, with the 11 S globulins of pistachio and cashew [11]. All three of these 11S globulins showed IgE cross-reactivity with the glycinin from Sichuan pepper seed, Zan b 2 [12]. ...

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Purification and Epitope Mapping of Jug r 4, a Major Walnut Allergen