Sarah Turecamo's research while affiliated with National Institutes of Health and other places
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Publications (7)
Background:
Inflammation and protein energy malnutrition are associated with heart failure (HF) mortality. The metabolic vulnerability index (MVX) is derived from markers of inflammation and malnutrition and measured by nuclear magnetic resonance spectroscopy. MVX has not been examined in HF.
Objectives:
The authors sought to examine the prognos...
Background: Heart failure (HF) is associated with metabolic alterations, including ketogenesis. However, determinants of ketogenesis and risk of mortality in HF is not defined. Total ketone bodies (KB) include β-hydroxybutyrate, acetoacetate, and acetone and can be measured in plasma by nuclear magnetic resonance (NMR). The aim of this study is to...
Introduction: Over 6 million people in the U.S. have heart failure (HF), less than half are expected to survive beyond 5 years. The need to better stratify mortality risk in HF is recognized. Frailty is associated with mortality in HF but not routinely measured clinically. As frailty is linked to inflammation and malnutrition, we hypothesized that...
Importance
Rural populations experience an increased burden of heart failure (HF) mortality compared with urban populations. Whether HF incidence is greater among rural individuals is less known. Additionally, the intersection between racial and rural health inequities is understudied.
Objective
To determine whether rurality is associated with inc...
Based on decades of both basic science and epidemiologic research, there is overwhelming evidence for the causal relationship between high levels of cholesterol, especially low-density lipoprotein cholesterol and cardiovascular disease. Risk evaluation and monitoring the response to lipid-lowering therapies are heavily dependent on the accurate ass...
Heart failure (HF) is associated with metabolic alterations, including insulin resistance (IR) . Perturbations in lipid metabolism and insulin signaling may impact outcomes, but the relationship between IR and mortality is not well characterized. The Lipoprotein Insulin Resistance Index (LPIR) is a score (0-100; higher values signify greater IR) ca...
Background: Rural-urban disparities in cardiovascular mortality are increasing, with higher heart failure (HF) mortality among rural residents. Whether rurality is also associated with an increased risk of HF incidence is not known.
Methods: A total of 27,119 Southern Community Cohort Study participants without prevalent HF receiving Centers for Me...
Citations
... Of note, 94% of our patients belonged to NYHA class IV. These results and a previously reported association of low valine serum levels with adverse events (all-cause mortality, re-hospitalization for worsening HF, and atrial fibrillation) in CHF patients who primarily belonged to NYHA classes II [12] or III and IV [13] may suggest the applicability of valine as a prognostic biomarker across the severity stages and types of HF. However, in an AHF cohort in which none of the patients belonged to NYHA class IV, ratios of leucine to phenylalanine and of branchedchain amino acids to aromatic amino acids, as well as plasma levels of leucine but not valine, were associated with cardiac death or hospitalization for worsening HF [14,15]. ...
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... ApoB100 comprises 4563 amino acids and is synthesized in the liver [23]. After lipidation via the microsomal triglyceride transfer protein (MTP), apoB100 is secreted as the main structural protein on VLDL [20,24]. It also contains a positively charged ligand-binding domain for the uptake of LDL through the LDLR [23]. ...
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... Whether rurality in this study represents the distance to health care remains to be elucidated. 34 Dr Laila Al-Shaar from the Pennsylvania State College of Medicine presented findings showing dietary sulfur amino acid intake was significantly associated with a higher risk of CVD, CVD mortality, and all-cause mortality in men and women, even after adjustment for nondietary and dietary risk factors. ...
