Sarah Mahne's research while affiliated with Louisiana State University Health Sciences Center New Orleans and other places
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Publications (4)
Rationale: Environmentally persistent free radicals (EPFRs) in combustion generated particulate matter (PM) are capable of inducing pulmonary pathologies and possibly contributing to the development of environmental asthma. In vivo exposure of infant rats to EPFRs demonstrates their ability to induce airway hyperresponsiveness to methacholine - a h...
Epidemiological studies consistently link inhalation of particulate matter (PM) to increased cardiac morbidity and mortality, especially in at-risk populations. However, few studies have examined the effect of PM on baseline cardiac function in otherwise healthy individuals. In addition, airborne PM contain environmentally persistent free radicals...
Exposure to airborne particles is associated with increased cardiovascular morbidity and mortality. During the combustion of chlorine-containing hazardous materials and fuels, chlorinated hydrocarbons chemisorb to the surface of transition metal-oxide-containing particles, reduce the metal, and form an organic free radical. These radical-particle s...
Citations
... Among these compounds, environmentally persistent free radicals (EPFRs) have received substantial attention due to their potential health effects. As a group of mixed complex pollutants, EPFRs can produce reactive oxygen species (ROS) through oxidation in a human body and are harmful to cardiovascular and respiratory systems (Balakrishna et al., 2011;Thevenot et al., 2013). The coexistence of particulate EPFRs and PAHs resulting from combustion sources has been reported, which shows the close relation among EPFRs, PAHs, and oxygenated PAHs (Borrowman ☆ This paper has been recommended for acceptance by Admir Créso Targino. ...
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... These ROS could induce oxidative stress in biological systems (Khachatryan et al., 2011;Dellinger et al., 2001;Ayres et al., 2008;Nel et al., 2006). In vitro and in vivo studies of inhalation exposure to EPFR containing particulate matter (PM) identified cardiac (Burn and Varner, 2015;Lord et al., 2011;Mahne et al., 2012;Chuang et al., 2017) and pulmonary (Fahmy et al., 2010;Balakrishna et al., 2011;Filep et al., 2016;Thevenot et al., 2013;Wang et al., 2011) dysfunction and effects on the central nervous system (CNS) (Wang et al., 2017;Allen et al., 2017;Costa et al., 2015;Solaimani et al., 2017;Ljubimova et al., 2018). Saravia et al. (2013) also studied adverse health effects of PM-associated EPFR on infants. ...
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... For example, EPFRs-containing particles could inhibit the activity of cytochrome P450 purified from the livers of rats (Reed et al., 2014), or induce airway hyperresponsiveness in neonatal rat lungs (Balakrishna et al., 2011). Inhaling of EPFRs-containing particles could cause pulmonary and cardiac inflammation and immune system diseases (Lord et al., 2011;Xu et al., 2021). In addition, EPFRs-containing particles could decrease wheat growth and green algae activity . ...
