Sarah M. Ryan's research while affiliated with University of Denver and other places

Publications (5)

Article
Full-text available
As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age‐related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to prote...
Article
Full-text available
As organisms are constantly exposed to the damaging effects of oxidative stress through both environmental exposure as well as internal metabolic processes, they have evolved a variety of mechanisms to cope with this stress. One such mechanism is the highly conserved p38 MAPK (p38K) pathway, which is known to be to post-translationally activated in...
Preprint
Full-text available
As organisms are constantly exposed to the damaging effects of oxidative stress through both environmental exposure as well as internal metabolic processes, they have evolved a variety of mechanisms to cope with this stress. One such mechanism is the highly conserved p38 MAPK (p38K) pathway, which is known to be to post-translationally activated in...
Preprint
Full-text available
As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age-related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to prote...
Article
Full-text available
The large repertoire of circadian rhythms in diverse organisms depends on oscillating central clock genes, input pathways for entrainment, and output pathways for controlling rhythmic behaviors. Stress-activated p38 MAP Kinases (p38K), although sparsely investigated in this context, show circadian rhythmicity in mammalian brains and are considered...

Citations

... Putative transcription factor binding motifs were predicted using iMotifs [47,48]. The 250 bp of sequence immediately upstream of each gene of interest was downloaded from FlyBase, and these sequences were used as input to iMotifs. ...
... Fruit flies deficient in p38b or overexpressing p38b in clock neurons showed opposite arrhythmic circadian behavior. p38b controls period gene expression programs in clock neurons through downstream transcription factor Mef2 -an established nuclear target of p38 (Zhao et al., 1999) -and kinase MNK (Dusik et al., 2014;Vrailas-Mortimer et al., 2014). In vertebrates, active p38 was detected in pineal gland neurons, suggesting p38 kinases are involved in circadian periodicity (Hayashi et al., 2003). ...