Sara So's research while affiliated with Johns Hopkins Medicine and other places

Publications (3)

Article
Full-text available
Background: Several measures have been developed to examine acute psychedelic effects (e.g. mystical-type and challenging experiences), but no measure assesses acute psychologically insightful experiences that may occur during psychedelic experiences. Aim: The purpose of this study was to develop and examine the psychometric properties of the Psych...
Poster
Full-text available
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in glandular secretions of Bufo alvarius toads and is synthesized. No human laboratory studies have been conducted, but evidence suggests 5-MeO-DMT may reduce depression and anxiety symptoms among those who use for spiritual or recreational reasons. Probing the effects of...
Article
Background: A recent epidemiological study suggested that 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used for spiritual and recreational reasons is associated with subjective improvement in depression and anxiety. Further exploration of the potential psychotherapeutic effects of 5-MeO-DMT could inform future clinical trials. Objectives: We exa...

Citations

... It has been shown that a decrease in resting state functional connectivity within the DMN brought about by LSD, a classic psychedelic, led to a less ruminative and more present-focused and mindful mental state (Speth et al., 2016). This disruption of DMN, combined with insight oriented and emotional breakthrough experiences facilitated by psychedelics, may lead to psychological flexibility, greater openness, a sense of well-being, and enhanced life satisfaction Roseman et al., 2019;Davis et al., 2021), which may be central to the possible role of classic psychedelics in treatment of PTSD. Psychedelics have also been shown to increase positive affect Frontiers in Pharmacology | www.frontiersin.org ...
... An important principle of a context-dependent or relational approach to psychedelics is that the psychedelic experience itself is an important mediator of subsequent therapeutic outcomesand there is much evidence to support this (Carbonaro et al., 2016;Carhart-Harris et al., 2016b;Davis et al., 2019Davis et al., , 2020Davis et al., , 2021bGarcia-Romeu et al., 2015;Gasser et al., 2015;Griffiths et al., 2016Griffiths et al., , 2018MacLean et al., 2011;Passie, 1997;Roseman et al., 2018;Ross et al., 2016;Schmid and Liechti, 2017). Specifically, a number of studies have found that 'peak' or 'mystical' -type experiences, which feature feelings of unity, transcendence of time, space and self, and positive mood, are predictive of subsequent positive therapeutic outcomes (Bogenschutz et al., 2015;Davis et al., 2019;Garcia-Romeu et al., 2015;Griffiths et al., 2016;Murphy et al., 2022;Pahnke, 1963;Roseman et al., 2018;Ross et al., 2016). ...