Sara L O'Kane's research while affiliated with University College Dublin and other places
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Publications (4)
Objective:
Anti-ribosomal-phosphoprotein antibodies (anti-Ribos.P Abs) are detected in 10-45% of NPSLE patients. Intracerebroventricular administration of anti-ribosomal-P Abs induces depression-like behaviour in mice. We aimed to discern the mechanism by which anti-Ribos.P Abs induce behavioural changes in mice.
Methods:
Anti-Ribos.P Abs were e...
Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis may facilitate detection of ovarian cancer in the early stages of the disease with identification of a panel of tumour specifi...
Profiling the autoantibody (AAb) repertoire in serum has been routinely used for many years for the diagnosis of autoimmune diseases, including rheumatoid arthritis, scleroderma, and lupus. In recent years, AAb profiling of cancers has become a prominent field in oncology research. Protein arrays enable high-throughput screening of clinical samples...
Calmodulin is an essential regulator of intracellular processes in response to extracellular stimuli mediated by a rise in Ca(2+) ion concentration. To profile protein-protein interactions of calmodulin in human brain, we probed a high content human protein array with fluorophore-labeled calmodulin in the presence of Ca(2+). This protein array cont...
Citations
... Very little data are currently available on the prevalence of anti-p53 antibodies in patients with epithelial ovarian cancer [16]. Murphy et al. [17] used ELISA to detect anti-p53 antibody in sera in normal heath individuals and ovarian cancer patients, however, the distribution of anti-p53 antibody in the two groups showed no significant difference. Additionally, Høgdall et al. [18] found that the frequency of anti-p53 antibodies in ovarian cancer patients increased somewhat with increasing clinical stage of disease, but the differences did not reach statistical significance. ...
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... Kv6.1 interacts with CaM in a calcium-dependent manner (O'Connell et al., 2010). The in teraction is mediated through a C-terminal binding motif that is exclusively found in Kv6.1 and not in other KvS members (Figure 8). ...
Reference: The Voltage-Dependent K+ Channel Family
... Generally, protein microarrays have been grouped into functional protein microarrays and analytic (protein-detecting) protein microarrays [121,122]. They can be fabricated using reverse capture of native proteins [121][122][123][124], recombinant proteins [120,125], cDNA expression libraries [126][127][128], and in-situ expression techniques [129][130][131][132]. Detailed information about how protein arrays work can be found elsewhere [120,133,134]. Despite the immense potential of this proteomics method in elucidating the pathogenesis of several autoimmune hair and skin conditions in humans [135], there is a paucity of studies that have employed it in human hair proteomics. ...
