Sandra J Sargent’s scientific contributions

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Publications (1)


Figure 1 Initial presentation: (a) nodule on right forelimb; (b) full-thickness ulceration on left carpus; (c) full-thickness ulceration on left forelimb; (d) left carpus; (e) ulcerated lesion on right hock; (f) metacarpal pad discoloration; and (g) right pinnal nodule
Figure 2 (a) Ulcerative dermatitis with necrosis of the underlying dermis, and heavy dermal infiltrates of eosinophils; (b) dermal infiltrates of eosinophils, inflammatory mast cells and small lymphocytes, with mild-to-moderate edema and mucinosis; and (c) 'flame figures' (arrows), consisting of collagen bundles surrounded by degranulated eosinophils, which, in turn, are surrounded by macrophages and multinucleated giant cells. The bars in (a), (b) and (c) are 600 μm, 60 μm and 60 μm, respectively
Figure 3 (a) Exacerbation of pad lesions after steroid discontinuation; and (b) crusting of lesions with underlying purulent discharge
Figure 4 Enlargement of pinnal nodule
Figure 5 Fourteen days post-pinnectomy
Novel presentation of eosinophilic granuloma complex in a cat
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July 2019

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4,886 Reads

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6 Citations

Journal of Feline Medicine and Surgery Open Reports

Kaitlin P Hopke

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Sandra J Sargent

Case summary A 9-year-old neutered male domestic shorthair cat was presented for multiple deep lesions on all four limbs and a nodule on the right pinna. The limb lesions ranged from nodules with necrotic surfaces to full-thickness ulcerations with exposure of muscles and tendons. The cat lived indoors only in a single-pet household and had no prior history of trauma. The owner reported that the lesions appeared abruptly and that the cat was not apparently painful or pruritic. Histopathology of the limb lesions and pinnal nodule confirmed severe lesions of the eosinophilic granuloma complex. Resolution of lesions was achieved with a combination of antibiotics, prednisolone, topical therapies, diet change and ciclosporin. Relevance and novel information This case report demonstrates a severe, aggressive presentation of eosinophilic granuloma complex. It will expose practitioners to atypical clinical signs of this commonly diagnosed disease.

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Citations (1)


... 34 Ciclosporin is commonly trialled for long-term management or in refractory cases and has also been successful in people. [43][44][45][46][47][48] Therefore, the second recurrence of the apparent HOCM phenotype that occurred during ciclosporin treatment was disappointing. One possible explanation is that the dose employed in this case (4 mg/kg) was less than the immunosuppressive dose reported in cats (regularly 7 mg/kg), and given the paucity of data on ciclosporin and its pharmacodynamics in cats, there is a distinct possibility that 4 mg/kg was a sub-therapeutic dose. ...

Reference:

Recurrent steroid‐responsive hypertrophic obstructive cardiomyopathy in a Maine Coon cat
Novel presentation of eosinophilic granuloma complex in a cat

Journal of Feline Medicine and Surgery Open Reports