Sana Majid's research while affiliated with Boston University and other places

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Publications (8)

Fig 1. eNOS activation is impaired in endothelial cells from...
Fig 2. The JUUL e-liquid and its individual components induce cellular...
Fig 3. JUUL e-liquids and nicotine salt impair nitric oxide production....
Fig 4. Heated particle fractions of JUUL e-liquids impair nitric oxide...
+1 Fig 5. Inflammatory gene expression and pod e-liquid exposure....
Pod-based e-liquids impair human vascular endothelial cell function
Article
Full-text available
  • Jan 2023
Pod-based electronic (e-) cigarettes more efficiently deliver nicotine using a protonated formulation. The cardiovascular effects associated with these devices are poorly understood. We evaluated whether pod-based e-liquids and their individual components impair endothelial cell function. We isolated endothelial cells from people who are pod users...
Effects of Pod-Based Electronic Cigarette Use on Vascular Health and Relation to Volatile Organic Compound Exposure in Young Adults
Preprint
  • Dec 2022
Background: Pod-based electronic cigarettes (e-cigarettes) use that contain nicotine salts is frequent among youth and young adults; thus, we compared the vascular health effects of pod-based e-cigarette use to combustible cigarette use. Methods and Results We performed a two center observational, cross-sectional study of healthy adults recruited f...
Association of electronic cigarette use with circulating angiogenic cell levels in healthy young adults: Evidence for chronic systemic injury
Article
  • Dec 2022
Background Circulating angiogenic cells (CACs) are indicative of vascular health and repair capacity; however, their relationship with chronic e-cigarette use is unclear. This study aims to assess the association between e-cigarette use and CAC levels. Methods We analyzed CAC levels in 324 healthy participants aged 21–45 years from the cross-secti...
Abstract 10999: Pod-Based E-liquids Induce Vascular Endothelial Cell Dysfunction
Article
  • Nov 2021
Introduction: Pod-based e-cigarettes including JUUL represent the most commonly used product type and more efficiently deliver nicotine; however, their cardiovascular effects are poorly understood. Methods: We evaluated endothelial function (cell viability by TUNEL and nitric oxide bioavailability using DAF-2DA) in human aortic endothelial cells (H...
Lipid profiles in users of combustible and electronic cigarettes
Article
  • May 2021
Electronic cigarette use has especially risen among adolescents and young adults. The aim of this study was to investigate fasting blood glucose and lipid profiles in chronic combustible cigarette and electronic cigarette users. We evaluated participants aged 21 to 45 ( n = 525, mean age 31 ± 7 years, 45% women) without established cardiovascular d...
Abstract 16510: Acute Use Impairs Vascular Function in Exclusive Juul Users (the Jive Study)
Article
  • Nov 2020
Introduction: The use of pod-based electronic cigarettes such as JUUL has especially increased among youth and young adults. Due to its popularity and high nicotine delivery as salts, JUUL warrants assessment of its cardiovascular effects. Hypothesis: JUUL use alters vascular function. Methods: In the JUUL Impact on Vascular Effects (JIVE) Study, w...
Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes
Article
  • Apr 2020
Background Electronic cigarettes (e‐cigarettes) have been proposed as a potential harm reduction tool for combustible cigarette smokers. The majority of adult e‐cigarette users continue to smoke combustible cigarettes and are considered dual users. The vascular impact of e‐cigarettes remains incompletely defined. Methods and Results We examined th...

Citations

... This may have many outcomes on our view of aging and COPD progression. Finally, there is evidence that vaping products, such as electronic cigarettes, can yield a similar lipid profile to conventional tobacco smoking [73], which could have many long-term complications. Therefore, significant work is required to elucidate the causality of altered lung cholesterol metabolism and signaling within the lungs, but it represents an important and exciting study area for pulmonary diseases such as COPD. ...
Reference: The Relationship of Cholesterol Responses to Mitochondrial Dysfunction and Lung Inflammation in Chronic Obstructive Pulmonary Disease
... Only selected e-liquids containing mint or menthol flavoring induced changes in inflammation and oxidative stress. These findings build upon the results of previous studies showing the effects of e-liquids on vascular endothelial cell function [16,24,25] by testing whole pod-based e-liquids and their heated fractions in cultured endothelial cells. Moreover, we found that the PG:VG vehicle with and without nicotine salt is not without harm. ...
Reference: Pod-based e-liquids impair human vascular endothelial cell function