Samiul Ansary’s research while affiliated with West Bengal University of Health Sciences and other places

Background Oxygen saturation (SpO 2 ) is an essential component during patient care and management because a variety of acute negative consequences on specific organs and systems can result from hypoxemia. Aim and Objective The effects of two homeopathic medicines, Coca erythroxylon 6CH and Vanadium metallicum 6CH, were explored against placebos on blood SpO 2 following a 6-min walk test (6MWT) in apparently healthy human volunteers after 3 days of intervention. Subjects and Methods A 3-day, randomized (1:1:1), double-blind, placebo-controlled pilot trial was conducted on 60 healthy human volunteers. Participants were randomized to Coca erythroxylon ( n = 20), Vanadium metallicum ( n = 20), and identical-looking placebos ( n = 20). Blood SpO 2 % (primary), peak expiratory flow (PEF; mL), and breath holding timing (s) were measured at baseline once preintervention and postintervention and again before and after a 6MWT. Interventions were administered 4 times a day for 3 consecutive days. Group differences were estimated using a one-way analysis of variance. Significance levels were set at P < 0.05 two-tailed. Results Statistically significant differences in pre- and postintervention mean changes were observed in blood SpO 2 % in the Coca erythroxylon group in comparison with the others ( F 2,57 = 3.815, P = 0.028); however, no such significant differences could be observed in PEF and breath holding time. No adverse events were reported. Conclusion Coca erythroxylon significantly increased blood SpO 2 % following a 6MWT in healthy human volunteers. It is necessary to conduct definitive trials to validate the findings. Trial Registration: CTRI/2022/08/044810; UTN: U1111-1281-3263.