Sabine Tricon's research while affiliated with University of Southampton and other places

Publications (16)

Article
Here the impact of APOE genotype on CHD risk in UK adults is reported, along with an analysis of APOE genotype × BMI/age/sex interactions. APOE genotype had a significant impact on fasting total:LDL-cholesterol (TC:LDL-C) ratio, triglycerides, % HDL3, and the Framingham 10-year CVD risk score (P<0.05), with an overall trend towards lower and higher...
Article
The prevalence of asthma and allergic diseases has increased dramatically over the past few decades with the highest incidence occurring in children. Most asthma and related atopic disorders have their origins in early life. Thus, it is imperative to understand the early life origins of the disease in order to identify targets for prevention and ea...
Article
Summary  There has been increasing interest in health benefits of conjugated linoleic acid (CLA) based on findings with laboratory animals. Some human studies have also suggested health benefits of CLA, but because of the mixes used these could not be readily associated with a particular isomer of CLA. A recent study examined the separate effects o...
Article
Full-text available
Interest in the development of dairy products naturally enriched in conjugated linoleic acid (CLA) exists. However, feeding regimens that enhance the CLA content of milk also increase concentrations of trans-18:1 fatty acids. The implications for human health are not yet known. This study investigated the effects of consuming dairy products natural...
Article
This review critically evaluates studies investigating the effects of conjugated linoleic acid on human health, including effects on body composition, blood lipids, liver metabolism, insulin sensitivity and immune function. It focuses mainly on human intervention studies, but includes some reference to animal and cellular studies which provide insi...
Article
Conjugated Linoleic Acid [“CLA”] is a collective term for a mixture of positional and geometric isomers of linoleic acid in which the two double bonds are conjugated, that is, contiguous, unlike the double bonds in linoleic acid, which are separated by a methylene group. Although diet is the major source of CLA in humans, there is no systematic dat...
Article
Full-text available
The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the concentration of this isomer in plasma and cellular lipids in healthy men. The study had a double-blind cross-over design. Subjects aged 34-60 years consumed dairy...
Article
Full-text available
Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immun...
Article
The purpose of this study was to determine the incorporation into erythrocytes of cis (c)-9,trans (t)-11 conjugated linoleic acid (CLA) and t10,c12 CLA consumed as supplements highly enriched in these isomers. Healthy men (31 ± 8 years) consumed 1, 2, and 4 capsules containing approximately 80 g/100 g of either c9,t11 CLA or t10,c12 CLA for sequent...
Article
Animal studies have suggested that conjugated linoleic acid (CLA), a natural component of ruminant meat and dairy products, may confer beneficial effects on health. However, little information on the effects of CLA on immune function is available, especially in humans. Furthermore, the effects of individual isomers of CLA have not been adequately i...
Article
The purpose of this study was to determine the incorporation into erythrocytes of cis (c)-9,trans (t)-11 conjugated linoleic acid (CLA) and t10,c12 CLA consumed as supplements highly enriched in these isomers. Healthy men (31 ± 8 years) consumed 1, 2, and 4 capsules containing approximately 80 g/100 g of either c9,t11 CLA or t10,c12 CLA for sequent...
Article
Conjugated linoleic acid (CLA) is reported to have weight-reducing and antiatherogenic properties when fed to laboratory animals. However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear. This study investigated the effects of 3 doses of highly enriched cis-9,trans-11 (0.59, 1.19, and 2.38 g/...
Article
Full-text available
Supplementation of the diet with fish oil, which is rich in the long-chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is reported to decrease several markers of immune function. However, whether EPA, DHA, or a combination of the 2 exerts these immunomodulatory effects is unclear. The objective of the...
Article
Full-text available
This study investigated the incorporation of cis-9,trans-11 conjugated linoleic acid (c9,t11 CLA) and trans-10,cis-12-CLA (t10,c12 CLA) into plasma and peripheral blood mononuclear cell (PBMC) lipids when consumed as supplements highly enriched in these isomers. Healthy men (n = 49, age 31 ± 8 years) consumed one, two, and four capsules containing...
Article
Full-text available
Background: Supplementation of the diet with fish oil, which is rich in the long-chain n−3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is reported to decrease several markers of immune function. However, whether EPA, DHA, or a combination of the 2 exerts these immunomodulatory effects is unclear. Objectiv...

Citations

... Consumer interest in the relationship between diet and health has focussed attention on the composition of food and in particular on its fatty acid composition. While beef is considered to be rich in saturated fatty acids (SFAs), it is also a source of polyunsaturated fatty acids (PUFAs), particularly omega (n)-3 PUFA and conjugated linoleic acid (CLA) which are considered to be beneficial to human health (Simopoulos, 2002;Yaqoob et al., 2006). Plants have the unique ability to synthesise de novo a-linolenic acid (18:3n-3), and forages such as grass and clover contain a high proportion (50-75%) of total total fatty acids as 18:3n-3 (Dewhurst et al., 2006). ...
... n-3 PUFAs are essential fatty acids for the human body, which can not only oxidize and supply energy in the body, but also participate in changes in cell structure and metabolites, thereby affecting cell functions. Studies have shown that n-3 PUFAs play an important role in the host immune response and inflammatory response of gastrointestinal tumors, so compared with isocaloric nutrition, n-3 PUFAs are the best choice for postoperative treatment (Kew, Mesa, & Tricon, 2004;Wallace, Miles, & Evans, 2001;Yaqoob & Calder, 1995). Our meta-analysis evaluated 10 RCTs to assess the impact of n-3 PUFA nutritional support on postoperative infectious complications, levels of inflammatory cytokines, immune cells and nutrient proteins, and length of stay in patients with gastrointestinal cancer. ...
... Beef is the second-largest meat product in China, second only to pork. 1,2 The price of local beef is on average 65 yuan ($9.4) per kilogram, with that of some imported beef reaching 150 yuan ($21.8) per kilogram. Chinese consumers are willing to pay a premium for imported beef. ...
... In contrast, studies in mice show that dietary CLA10,12 increases the expression and circulating levels of inflammatory mediators and macrophage infiltration into adipose tissue [20,21]. Clinical trials also show inconsistent results, with some studies reporting that CLA10,12 may have pro-inflammatory effects compared to CLA9,11 [22][23][24][25], while other studies show no effects and no differences between the CLAs [26,27]. ...
... is low . The extent of conversion of aLNA to DHA is even less clear ( Table 5 ) . The highest estimated fractional conversion is 4 % ( Emken et al . 1994 ) , while most other studies have reported lower estimates of conversion ( 0·05 % or less ) ( Emken et al . 1999 ; Salem et al . 1999 ; Vermunt et al . 2000 ; Pawlosky et al . 2001 , 2003a , b ; Burdge et al . 2003 ; Goyens et al . 2005 ; Hussein et al . 2005 ) and one study failed to detect significant incorporation of stable isotope into DHA above background 13 C enrichment ( Burdge et al . 2002 ) . Pawlosky et al . ( 2001 ) have suggested estimates for the efficiency of conversion of individual steps in the desaturation – elongation pathway from kinetic analysis bas ...
... Several prospective studies reported no clear association [42,43] or a negative relationship [44] between rTFA intake and CVD risk. Given that humans are capable of converting around 20% of trans-11 18:1 to cis-9, trans-11 conjugated linoleic acid (CLA) [45,46], and cis-9, trans-11 CLA does not appear to have adverse effects on plasma TAG, total, LDL or high density lipoprotein-(HDL) cholesterol in human subjects [47] it has been argued that due to the relatively high abundance of trans-11 18:1 in ruminant products, rTFA may be less harmful than iTFA [48]. Furthermore, the concentration of trans-9 16:1 in plasma phospholipids that originates from milk and dairy products in the human diet has been reported to be negatively associated with type 2 diabetes [49], possibly due to elongation and desaturation to cis-9, trans-11 CLA, a known anti-carcinogen, in adipose tissue [51]. ...
... Unhealthy diets are associated with higher levels of inflammation [24,25]. Studies in adolescents or children have reported a higher risk for severe asthma in those consuming fast food three or more times per week [48] or with a low intake of fruits and vegetables, fish, butter, and dairy fat [49]. In adults, a high fish and fruit diet was related to a lower incidence of asthma [50]. ...
... LPS-stimulated macrophages from human and mice showed increased TNF-α and IL-6, and the activation of the inflammatory NFκB pathway in APOE4 compared to APOE3 carriers (65). We have previously shown higher levels of h-CRP, P-selectin and E-selectin in normal-weight healthy APOE4 individuals in comparison to APOE3/E3 (67). Similarly, in the mouse brain, an APOE4 genotype was associated with increased microglial activation, IL-1β and lipid peroxidation (65,66). ...
... In healthy humans, the fasting plasma or serum NEFA concentration is typically about 600 µM. Burdge et al. [53] reported the contribution of CLA9,11 and CLA10,12 to the plasma NEFA pool in healthy young men prior to and after using supplements of CLA9,11 and CLA10,12. They showed that CLA9,11 contributes on average 0.35% of FAs in the fasting NEFA pool. ...