Sabina Sheppard-Olivares's research while affiliated with Kansas State University and other places

Publications (5)

Article
Full-text available
Background: Insulinomas are the most common tumour of the endocrine pancreas in dogs. These malignant tumours have a high metastatic rate and limited chemotherapeutic options. The multi-receptor tyrosine kinase inhibitor sunitinib malate has benefit in the treatment of metastatic insulinoma in people. Toceranib phosphate, an analogous veterinary a...
Preprint
Full-text available
BACKGROUND: Insulinomas are the most common tumour of the endocrine pancreas in dogs. These are malignant tumours with a high metastatic rate and limited efficacious chemotherapeutic options available. Recent literature supports the use of the multi-receptor tyrosine kinase inhibitor sunitinib malate for treatment of metastatic insulinoma in people...
Preprint
Full-text available
BACKGROUND Insulinomas are the most common tumour of the endocrine pancreas in dogs. These are malignant tumours with a high metastatic rate and limited efficacious chemotherapeutic options available. Recent literature supports the use of the multi-receptor tyrosine kinase inhibitor sunitinib malate for treatment of metastatic insulinoma in people....
Article
Thyroid carcinoma is the most common endocrine malignancy in dogs. Thyroidectomy and radiation therapy control local disease, yet are not always feasible, and efficacious medical therapies need to be identified. Toceranib phosphate has been reported to provide clinical benefit (CB) in dogs with thyroid carcinoma, while its role in treatment-naïve t...

Citations

... [27][28][29][30] While approved for the treatment of mast cell disease, 31 clinical responses to toceranib have been documented in dogs with a spectrum of solid tumour types, including several of neuroendocrine histology. 29,[32][33][34][35][36][37][38][39][40][41][42] A retrospective study of five dogs diagnosed with metastatic or recurrent insulinoma and treated with toceranib suggested improved outcomes when compared with seven dogs treated palliatively. 43 A case report describing a dog with metastatic insulinoma reported longterm glycaemic control with toceranib. ...