Sa’ar Lanir-Azaria's research while affiliated with Hebrew University of Jerusalem and other places

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Publication (1)

Enhanced wakefulness following lesions of a mesopontine locus essential for the induction of general anesthesia
Article
  • Dec 2017
The induction of general anesthesia shares many features with the transition from wakefulness to non-rapid eye movement (NREM) sleep, suggesting that the two types of brain-state transition are orchestrated by a common neuronal mechanism. Previous studies revealed a brainstem locus, the mesopontine tegmental anesthesia area (MPTA), that is of singu...
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Citations

... It seems likely that anesthesia transiently silenced a group of neurons necessary for wakefulness, and that these are the same neurons that, when silenced, produce the behavioral effects described by Bremer and others. Interestingly, however, while other GABAergic agents produce loss of arousal, neither silencing this region with lidocaine or tetrodotoxin Minert et al., 2017;Avigdor et al., 2021), nor ablating it caused loss of arousal Lanir-Azaria et al., 2018). No specific cell populations have been identified as mediating the effect of pentobarbital in this region (Minert et al., 2017). ...
Reference: A Century Searching for the Neurons Necessary for Wakefulness
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