SK-W Liu's research while affiliated with University of Toronto and other places

Publication (1)

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Inhibition of hippocampal neurogenesis is implicated in neurocognitive dysfunction after cranial irradiation for brain tumors. How irradiation results in impaired neuronal development remains poorly understood. The Trp53 (p53) gene is known to regulate cellular DNA damage response after irradiation. Whether it has a role in disruption of late neuro...


... In our research, we also found that Z734 increased the HERC3 and p53 levels. Many studies have demonstrated that p53 can regulate apoptosis, trigger the differentiation process, and block the shift from regeneration to carcinogenesis [32,54,55]. HERC3 is highly homologous to HERC4, and it is related to p53 [56,57]. ...