S. Wehrmeyer's research while affiliated with Max Planck Institute for Molecular Genetics and other places
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Publications (8)
Protein array technology has emerged as a new tool to enable ordered screening of proteins for expression and molecular interactions in high throughput. Besides classical solid-phase substrates, such as micro-titre plates and membrane filters, protein arrays have recently been devised with chip-sized supports. Several applications on protein chips...
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex disorders have also been mapped to this chromosome, and...
On Feb 4, 2004 this sequence version replaced gi:7417414. -------------- Genome Center Center: Insitute of Molecular Biotechnology Center code: IMB Web site: http://genome.imb-jena.de/ Contact: gscj-submit@genome.imb-jena.de -------------- Project Information Center project name: U141 Center clone name: SCb-318B17 -------------- Summary Statistics...
On Jun 16, 2001 this sequence version replaced gi:7263184.
On Feb 22, 2002 this sequence version replaced gi:14475924.
Citations
... Kuwahara et al (24) reported that the germinal-center associated nuclear protein encoded on HSA21 was associated with tumorigenesis and development of breast cancer. The human GRIK1 gene is a HSA21 gene, located on the q21.3 region of the chromosome (25). Similar to other HSA21 genes such as RCAN1.4, ...
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... TTC3, also known as TPRDIII, RNF105, and DCRR1, was first discovered in 1996 (Ohira et al. 1996;Tsukahara et al. 1996). Subsequently, the sequencing of chromosome 21 was completed in 2000, and the TPRD gene was renamed TTC3 (Hattori et al. 2000). TTC3 is located at 21q22.2 (Eki et al. 1997;Tsukahara et al. 1996). ...
... Therefore, protein microarrays were also employed as a tool for phosphoproteomic analysis, as this allows detection of phosphorylation targets as well as molecular interactions using thousands of immobilized probable protein targets [32][33][34][35]. This technique was first employed for A. thaliana proteins [36]. Before designing the high-throughput microarrays with A. thaliana kinases [37], low throughput microarrays were designed to understand the number of microarrays analyzed for one phosphorylation on one microarray [38,39] followed by medium throughput with barley kinases [40]. ...
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