S. Vidyadhara's research while affiliated with Chebrolu Hanumaiah Institute of Pharmaceutical Sciences and other places

Publications (89)

Article
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Objective: In vivo pharmacokinetic studies of clopidogrel and dipyridamole floating microballoons to check their bioavailability enhancement. Methods: The bioanalytical method development was carried by using HPLC with column Poroshell 120 EC-C 18; 4.6x100 mm. The in vivo pharmacokinetic studies were performed in Wistar male rats and the obtained d...
Article
Phytochemical evaluation of the alcoholic extract of Rubia cordifolia Linn. roots resulted in the identification of two anthraquinone compounds 1a (1,4-dihydroxyanthracene-9,10(4aH,9aH)-dione) and 1b (2-methylanthracene-9,10(4aH,9aH)-dione). The isolated compounds were characterized by spectroscopic methods and their structures were established. Th...
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Objective: In the current research work, dipyridamole, a BCS class–II drug, was aimed to be formulated as floating controlled release microballoons using ethyl cellulose as polymer and span 80 as surfactant to improve the gastric retention of drug as the multi-particulate dosage forms have tremendous advantages over single unit dosage forms. Method...
Article
It is necessary to discover antidiabetic agents since diabetes is one of the most rapidly growing disorders . It is estimated by WHO that more than 420 million people are suffering from diabetes worldwide. It is very important to synthesize novel molecules for the treatment of diabetes. One of recent and very effective targets is Peroxisome Prolife...
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A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives have been synthesized and characterized by various spectroscopic techniques including FTIR, mass and 1H NMR. In current study, we have followed standard methods for the synthesis of novel molecules, docking and screening against mycobacterium species. The compounds w...
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Telmisartan belongs to a BCS class II drug i.e. low solubility and high permeability. It is an angiotensin II type-I receptor blocker essentially used for the treatment and curing of hypertension. The critical problem facing with telmisartan as it shows low solubility in biological fluids which results into less bioavailability after oral administr...
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Stability study for dolutegravir bulk drug was performed and the degradation products formed were identified by chromatography (HPLC, LCMS) and spectroscopy (ESI-MS, FTIR, ¹H and ¹³C NMR) techniques. Degradation of the drug in acidic and peroxide environment yielded one common major degradant f ((2,4-difluorophenyl) methanamine) with a mass peak at...
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Objective: The present study deals with the formulation and evaluation of fast dissolving buccal films for effective treatment option in the gastroesophageal reflux disease.Methods: Esomeprazole fast dissolving buccal films are a convenient formulation of which can be taken with or without water. In the present investigation, polyvinyl alcohol and...
Article
Aim: The purpose of the present work was to formulate fast dissolving tablets (FDTs) of poorly water-soluble drug Atorvastatin using natural superdisintegrants like starches extracted from Entada scandens seed powder. Objectives: The present work mainly focuses on solubility enhancement of BCS Class-II drugs using starch as superdisintegrant which...
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In the traditional systems of medicine, many medicinal plants are being prescribed for inflammatory condition. The present study was aimed at investigating the ameliorative effect of Adenanthera Pavonina (AP) in sciatic nerve transection (axotomy)-induced peripheral neuropathy in rats. The behavioral parameters were evaluated by using the seeds of...
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In the traditional systems of medicine, many medicinal plants are being prescribed for inflammatory condition. The present study was aimed at investigating the ameliorative effect of Adenanthera Pavonina (AP) in sciatic nerve transection (axotomy)-induced peripheral neuropathy in rats. The behavioral parameters were evaluated by using the seeds of...
Article
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Objective: The objective and purpose of the analysis have sensibly assessed by selecting of a rapid and sensitive RP-HPLC method for Entecavir in bulk and pharmaceutical dosage form by using the most commonly employed C-18column with UV detection.Methods: In estimation by RP-HPLC method Agilent 1120 compact LC system with variable programmable UV d...
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The prime aim of the present investigation was to develop and validate a novel, precise, accurate, specific, rapid and economical stability-indicating isocratic reverse phase liquid chromatography method for the quantitative simultaneous estimation of valsartan and hydrochlorothiazide in bulk and marketed formulations. Estimation of drugs in this c...
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The present paper illustrates about development and validation of a new, simple, precise and accurate RP-HPLC method with enhanced sensitivity for the simultaneous determination of Doxylamine Succinate (DAS) and Pyridoxine Hydrochloride (PDH) in bulk and its dosage forms. The drug showed good absorbance in mobile phase at 263 nm. Under the optimize...
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Background Teneligliptin is a new FDA approved drug for treating Diabetes Mellitus. There are no reported evidences for their identified degradation products and their effects on humans. MethodsA simple and new stability indicating RP-HPLC method was developed and validated for identification of Teneligliptin and its degradants on Kromasil 100- 5C1...
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A simple and new colorimetric method was developed for the estimation of emtricitabine. The proposed colorimetric method is based on the diazotisation of amine group present in emtricitabine, followed by colour complex formation using β-naphthol reagent. Parameters affecting the reaction were studied and conditions were optimized. The absorption ma...
Article
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Background Teneligliptin is a new FDA approved drug for treating Diabetes Mellitus. There are no reported evidences for its degradation products during stability studies and their effects on humans. MethodsA simple and new stability indicating RP-HPLC method was developed and validated for identification of Teneligliptin and its degradants on Kroma...
Article
A simple, precise, accurate, reproducible and economical stability-indicating reverse phase liquid chromatography method was developed and validated for the quantitative simultaneous estimation of nebivolol and indapamide in bulk and marketed formulations. Estimation of drugs in this combination was done with a C18 column [Kromasil column. 250mm ×...
Article
A novel stability indicating reverse phase liquid chromatographic method has been developed for the simultaneous estimation of Losartan Potassium, Ramipril and Hydrochlorothiazide in bulk and Pharmaceutical formulations by using reverse phase Kromasil 100-5 C18 column [250mm x 4.6mm].The mobile phase (Methanol: phosphate buffer-pH 4.0) in the ratio...
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A new reverse phase-high performance liquid chromatography (RP-HPLC) have been developed and validated for the determination of Erlotinib in bulk drug and pharmaceutical dosage form. The developed method is rapid, accurate, precise, simple and economical. The separation was carried out using column Hypersil ODS C-18 (150 mm x 4.6 mm 5 μm particle s...
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A stability indicating RP-HPLC method was developed for the simultaneous estimation of the anti hypertensive drugs Hydrochlorothiazide, Amlodipine Besylate and Telemisartan. These drugs were subjected to stress studies under different conditions as per ICH guidelines. The separations were carried out using C18 reverse phase column (Agilent ODS UG 5...
Article
The objective of present study was to improve solubility and dissolution rate of rosuvastatin by formulating it as a self micro emulsifying drug delivery system (SMEDDS). The SMEDDS were prepared by using capmul McM and capryol 90 as oils Polaxomer 407 as surfactant and Transcutol hP and Soluphor P as co-surfactants. The liquid SMEDDS were then con...
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The present study describes the development and validation of stability indicating RP - HPLC method for the estimation of nelarabine, a chemotherapy drug. Nelarabine was subjected to stress studies under different conditions as per ICH guidelines. The separations were carried out using C18 Reverse Phase Column (Cosmicsil Adge 150 × 4.6 mm, 5μm) emp...
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A novel hydrazide derivative of ciprofloxacin was synthesized and evaluated for its antibacterial activity against E. coli, B. subtilis, and P. auregenosa. The compound was purified by column chromatography and spectrally elucidated using U.V. and FTIR techniques. The compound has shown activity at 10 μg/mL concentration against gram negative bacte...
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This study investigated the antidiarrheal and cytotoxic effects of Ethanolic extract of Alsotinia scholoris leaves. Antidiarrheal effect was measured in castor oil induced-diarrhea, and enteropooling models in albino mice. Cytotoxicity was investigated by zebra fish lethality bioassay. In castor oil induced diarrhea we measure the parameters like t...
Article
A simple, precise, accurate, reproducible and economical reverse phase liquid chromatography method was developed and validated for the quantitative simultaneous estimation of Atazanavir and Ritonavir in bulk and marketed formulations. Estimation of drugs in this combination was done with a C18 column Kromasil 100-5C18 column [250mm x 4.6mm].using...
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The present research work was focussed on the preparation as well as the evaluation of Aceclofenac solid dispersions for analgesic, anti-inflammatory and immunosuppressant activities. Solid dispersions were formulated using cros-carmellose sodium as polymer in different ratios. The solid dispersions were prepared using physical mixture, solvent eva...
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The present paper illustrates about development and validation of a new, simple, precise and accurate Spectrophotometric and RP-HPLC method with enhanced sensitivity for the determination of the antidepressant paroxetine (PXT) in bulk and its dosage forms. The drug showed good absorbance in water at 294 nm, hence water is selected as a solvent and...
Article
Aim: The aim of this study is to formulate and evaluate zolmitriptan orodispersible tablets using novel excipients. Zolmitriptan is an antimigraine drug used in the treatment of migraine. Materials and Methods: In the present investigation, an attempt has been made to enhance the solubility and dissolution rate of zolmitriptan by formulating it as...
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The objective of the present investigation is to prepare and evaluate the sustained release matrix tablets of Diltiazem hydrochloride. In this investigation, sustained release matrix tablets of Diltiazem hydrochloride were prepared using a natural polymer, is Gum karaya. Total twelve formulations (DK1-DK12) were prepared by using different proporti...
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Aim: The present investigation concerns with the developments of hydrodynamically balanced tablets of cefixime trihydrate were designed to prolong the gastric residence time after oral administration and thereby increasing drug bioavailability. Materials and Methods: Floating tablets of cefixime trihydrate were prepared by direct compression using...
Article
In the present work an attempt has been made to increase the solubility and dissolution rate of lansprozole by formulating it as solid dispersions by lipid carriers such as compritol 888 ATO Phospholipon 90 H and Lipoid S100 by using Fusion method, Kneading method and solvent evaporation method. Further the solid dispersions were compressed as orod...
Article
Aim: This study deals with the formulation of fast dissolving buccal films of doxylamine succinate is an antihistaminic commonly used for the prevention and treatment of nausea and vomiting in pregnancy. Doxylamine is a histamine H1 antagonist with pronounced sedative properties. It is used in allergies, antiemetic, and hypnotic. Doxylamine has als...
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Aim: The present investigation highlights the formulation and evaluation of matrix tablets of propranolol hydrochloride (HCl) using a natural polymer, is gum kondagogu. Materials and Methods: Wet granulation method was used for the preparation of matrix tablets of propranolol HCl using varying proportions of natural polymer as a release retardant,...
Article
A simple, rapid, specific and precise liquid chromatography–tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for quantification of Erlotinib, in human plasma. Erlotinib d6 was used as internal standard, added to plasma sample prior to extraction using acetonitrile as a precipitating agent. Chromatographic separation was...
Article
A simple, accurate, precise high-performance liquid chromatographic (HPLC) method has been developed and validated for the simultaneous determination of abacavir sulphate (ABA) and lamivudine (LAM) in combined dosage form. Separation was performed on a C18 column [Agilent ODS UG 5 column, 250 mm × 4.5 mm], with methanol: water (50:50 V/V) isocratic...
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In the present investigation an attempt has been made to formulate medicated lozenges containing amoxicillin trihydrate. There are several amoxicillin trihydrate dosage forms in the market such as tablet, capsule, suspension and syrup. Still there is a need for more variant dosage forms which acts effectively and locally. The benefits of the presen...
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The objective of the present study was to investigate the influence of polymer level and type of some hydrophobic polymers, Dammar gum and Copal gum with meltable carriers such as Poly ethylene glycol 6000 (PEG 6000) and carnauba wax, on the release rate and mechanism of lamivudine (LM) from matrix tablets prepared by hot- melt granulation techniqu...
Article
Two simple, precise, and easy methods were successfully developed for the estimation of Atomoxetine hydrochloride in bulk and pharmaceutical dosage forms. The first method was UV-spectrophotometry, which is linear in the concentration range of 20-100μg/ml at maximum absorbance (γmax) 270 nm. The correlation coefficient was found to be 0.999. The ac...
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Rizatriptan Benzoate is potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor. It commonly used for relief of headaches in treatment of migraine. Conventional tablets of RZT are not capable of rapid action, which is required for immediate relief from migraine pain. The aim of present work is to...
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A cataract is a condition where clouding of the eye’s natural lens occurs. It acts a major complication in case of diabetes mellitus. The present study investigates the effect ofmethanolic extract ofZiziphusxylopyrus fruiton cataract induced by glucose. Ziziphusxylo pyrus, a traditional folklore plant has antioxidant, antiulcer properties. Goat eye...
Article
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A. Abstract: a formulation of Fast dissolving Tablets (FdTs) using solid dispersions (sds) and cyclo-dextrin (cd)-based complexes will improve the solubility, dissolution rate and, hence, bioavailability of certain poorly soluble drugs. In the present study, an attempt was made to improve the solubility and dissolution rate of Telmisartan by sd tec...
Article
A simple, precise, accurate, reproducible, economical and sensitive reverse phase liquid chromatography method was developed and validated for the simultaneous estimation of Domperidone and Pantoprazole in bulk and marketed formulations. Evaluation of drugs in this combination was performed with a C18 column [ Kromasil column. 250mm × 4.5 mm] using...
Article
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A. Abstract: a formulation of Fast dissolving Tablets (FdTs) using solid dispersions (sds) and cyclo-dextrin (cd)-based complexes will improve the solubility, dissolution rate and, hence, bioavailability of certain poorly soluble drugs. In the present study, an attempt was made to improve the solubility and dissolution rate of Telmisartan by sd tec...
Article
Full-text available
A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine Besylate and Telmisartan in pharmaceutical formulation using RP - C18 column. The mobile phase (acetonitrile: acetate buffer adjusted to pH 5 with orthophosphoric acid) was pumped at a flow rate of 1.0...
Article
A simple and sensitive spectrophotometric method for the determination of ramipril and telmisartan in pharmaceutical dosage forms has been developed. The absorption maxima were found at 220nm for ramipril and 297nm for telmisartan using 0.1N NaOH as solvent. Beer's law was obeyed for both the drugs in the concentration range of 2-10μg/ml with corre...
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Solubility is an important physicochemical factor affecting absorption of drug and it's therapeutic effectiveness. The present research work is to improve the solubility and dissolution rate of olmesartan medoxomil by complexation with HP ß-Cyclodextrins. The inclusion complexes were prepared by lyophilization and solvent evaporation method. The pr...
Article
Venlafaxine hydrochloride is used in the treatment of depression and anxiety disorders. The objective of the present study was to prepare the orodispersible tablets of venlafaxine hydrochloride by sublimation method. Camphor and menthol are used as subliming agents. Tablets are prepared by direct compression process with calcium silicate and sodium...
Article
A simple, fast, precise reverse phase isocratic high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Enalapril Maleate and Hydrochlorothiazide in marketed formulations. Estimation of drugs in this combination was done with a C18 column [ ODS UG column. 250mm × 4.5 mm ] using mobile phase of...
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Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of pH and hydrodynamic conditions of gastrointestinal tract (GIT). The present study was aimed to develop osmotic controlled extended release formulations of verapamil hydrochloride an angiotensin II receptor...
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A new, simple, accurate, precise and rapid reversed-phase high performance liquid chromatographic (RP-HPLC) method has been developed and subsequently validated for the simultaneous estimation of Sitagliptin phosphate and Metformin hydrochloride in pure and dosage forms. The proposed method is based on the separation of the two drugs in reversed-ph...
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A simple, accurate, precise, economical and reproducible UV spectrophotometric method has been developed for the simultaneous estimation of hydrochlorothiazide, amlodipine besylate and telmisartan in bulk and in combined tablet dosage form. The stock solutions were prepared in methanol followed by the further required dilutions with distilled water...
Article
The objective of this study was to develop a solid dispersion method for enhancing the aqueous solubility of aprepitant (BCS class II drug). In the present study a simplified definitive equivalent formulation is targeted by preparing a solid dispersion using hot melt extrusion. Model formulation isolated from a range of carrier-plastizer mixtures b...
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A novel, simple, rapid and precise reverse phase isocratic high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Atorvastatin and Ezetimibe in pure and marketed formulations. Estimation of drugs in their formulations were done with a Kromasil 100-5C18 Column[250mm × 4.6mm]using mobile phase o...
Article
The present research work was focused on the antibacterial activity of seed extracts of Sesamum indicum. The aqueous and ethanolic extracts of seeds prepared from various extraction procedures were evaluated against a Gram positive bacteria Bacillus subtilis and a Gram negative bacterial strain, Escherichia coli by agar well diffusion method. Preli...
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The present investigation was focused on the development and evaluation of controlled release pellets of losartan potassium with eudragit S 100 and hydroxypropyl methyl cellulose phthalate (HPMCP) by employing pan coating technique. eudragit S 100, a high viscosity grade controlled release polymer, was mainly used as coating agent for regulating th...
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Physicochemical properties such as low solubility or high lipophilicity were the major unavoidable problems faced by the pharmaceutical industry in the development of a pharmacologically active substance with relevant activity and minimum toxicity. Hence, various techniques are used for the improvement of the solubility of poorly water soluble drug...
Article
Rosuvastatin calcium (RST) is a selective and competitive inhibitor of HMG-CoA reductase, mainly used in the treatment of hypercholesterolemia, hyper triglyceridemia and atherosclerosis. In this work a new attempt was made to enhance the solubility, dissolution rate and oral bioavailability of poorly soluble rosuvastatin by formulating it as solid...
Article
Solid dispersions of irbesartan with poly ethylene glycol (PEG-6000) were prepared and further compressed as tablets by using superdisintegrants such as croscarmellose sodium, crospovidone, sodium starch glycolate (SSG). The solid dispersions of irbesartan with PEG-6000 at different ratios were prepared by physical mixing, solvent evaporation and k...
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In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of verapamil hydrochloride. Verapamil hydrochloride was formulated as oral controlled release matrix tablets by using the polyethylene oxides (Pol...
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The present study outlines a systematic approach for designing and development of Ofloxacin floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Ofloxacin have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time af...
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Oral controlled matrix tablets of Diphenhydramine HCl were formulated by different hydrophilic polymers such as hydroxypropyl methylcellulose K15 M (HPMC K15 M), poly ethylene oxide WSR 301 (PEO WSR 301) and carbopol 940 P along with pharmaceutically acceptable electrolytes. The drug candidate selected is diphenhydramine HCl which is widely used as...
Article
The purpose of the present study was to prepare an acceptable nanosuspension of ritonavir by increasing the aqueous solubility, dissolution and hence oral bioavailability. Ritonavir is having low aqueous solubility and high permeability which can be considered as drug belonging to class-II according to BCS. In this study nanosuspension technology w...
Article
The present investigation was mainly focused on the development of controlled release pellets of verapamil HCl with ethyl cellulose and hydroxylpropyl methyl cellulose phthalate (HPMCP) by employing PAN coating technique. Ethyl cellulose 7cps a high viscosity grade controlled release polymer was mainly used as coating agent for regulating the drug...
Article
The present study deals with the formulation of fast dissolving buccal films of Zolmitriptan which is used for thetreatment of Migraine. The concept of fast dissolving drug delivery emerged from the desire to provide patient withmore conventional means of taking their medication. In the present research work polyvinyl alcohol and polyvinylpyrrolidi...
Article
Full-text available
A simple precise and economical reverse phase high performance liquid chromatographic method has been developed and validated for the estimation of atenolol and nifedipine simultaneously in combined dosage form. The method was developed using agilent ODS C18 column with a mobile phase constituting of methanol:acetonitrile:phosphate buffer(60:20:20)...
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A simple, accurate and precise reverse phase high performance liquid chromatography (RPHPLC) method has been developed and validated for the simultaneous determination of aspirin and simvastatin in combined dosage form. Separation was performed on a C18 column [ODS column, 250mm × 4.5mm with particle size 5μm. with a mobile phase consisting of acet...
Article
The present study deals with the formulation of fast dissolving films of nizatidine as a model drug which is used for the treatment of acid-reflux disorders, peptic ulcer disease, and active duodenal ulcer. Rapidly dissolving dosage forms have acquired great importance in pharmaceutical industry because of their unique properties. In the present re...
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Venlafaxine hydrochloride was formulated as oral controlled release matrix tablets using hydrophilic polymer such as hydroxypropyl methyl cellulose (HPMC K 15 M) along with electrolytes. In this work a new attempt was made for in situ interactions between drug and electrolytes were devised to control the release of highly water soluble drugs from o...
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Solid dispersions of lovastatin were formulated using pregelatinised starch (PGS) as super disintegrant and were further compressed into tablets by using various diluents such as lactose, dicalcium phosphate (DCP) and microcrystalline cellulose (MCC) to enhance the bioavailability. The solid dispersions were prepared by physical mixing, solvent eva...