S R Naik’s research while affiliated with Federal University of Paraíba and other places

... Antidepressant, hepatoprotective, antioxidant, anticancer, antibacterial and antispasmodic properties are all present in piperine's fruit (2). Additionally, piperine has the power to lower inflammation, relieve pain, enhance digestion, and boost bioavailability (3). Additionally, piperine is capable of improving bioavailability, increasing digestion and reducing discomfort (4). ...

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Corrosion Inhibition of carbon steel XC70 in two acidic media (0.1 N H 2 SO 4 ( and (0.1 N HCl) by weight loss method using Black Pepper Extract as corrosion inhibitor

... Furthermore, peptaibols seem to cause pathological changes to the ultrastructure of mitochondria (Reed and Lardy, 1975;Bruckner and Toniolo, 2013). It has been shown that the peptaibol AAM exhibits trypanocidal activity in a mouse model for trypanosomiasis (Kumar et al., 1991), effect attributed to the channel-forming capacity that dissipates the parasite mitochondrial membrane potential, or alters the parasite's plasma membrane integrity (Nagaraj et al., 2001). ...

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Synergistic combination of alkylphosphocholines with peptaibols in targeting Leishmania infantum in vitro

... Terpenes are bioactive compounds that occur both as hydrocarbons and terpenoids (oxygen-containing compounds), present naturally in many herbs, and are known to possess significant hypoglycaemic properties [20]. Terpenes show antidiabetic potential by either of the mechanisms that include stimulation of insulin secretion [21][22][23][24], enhanced plasma BER (β-endorphin immunoreactivity) by activation of α1-ARs to improve the discharge of β-endorphin, which has the potential to excite opioid micro-receptors to diminish gluconeogenesis in the liver and boost glucose uptake in the soleus muscle [25,26], α-glucosidase inhibition [27][28][29], increasing glucose uptake and glycogen synthesis and blood insulin concentrations. It appears that the reason for this outcome was the facilitation of insulin secretagogue impact in β-cells of the pancreas [30] by appreciably augmenting the blood pyruvate concentration and liver glycogen level [31] by improving insulin discharge from β-cells of the pancreas, which is due to improved stimulation of β-cells and insulin synthesis [32][33][34], and by enhancing glucose utilization in striated muscles, which leads to lower plasma glucose levels and increases in insulin discharge from pancreatic β-cells [24,28,35,36]. ...

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Anti-diabetic activity-guided isolation of α-amylase and α-glucosidase inhibitory terpenes from Capsella bursa-pastoris Linn.

... Some studies have reported that pepper had a high antibacterial ability (75% antibacterial activity) to fight infections in the respiratory tract and oral cavity, had helped improve mood, and had battled depression, reducing stress and fatigue due to substances that had caused the body to increase serotonin production 5 . Piperine, found in black pepper, has the chemical formula C 17 H 19 NO 3 , belonging to the alkaloid, characterized by its mild alkaline nature and yellow crystalline structure, showing strong solubility in ethanol and chloroform. ...

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Extraction of Bioactive Compounds from Pepper (Piper Nigrum) in Vietnam Using Response Surface Methodology and the Piperine Purification Process

... The fruits include Central Nervous System (CNS) depressants, antipyretic, analgesic, hepatoprotective, bioavailability enhancers [16][17] , antioxidant 18 and antiinflammatory activities. Piplartin, Piperlogumine, Piperidine, Starch, Resin and pungent alkaloids are all found in the fruits of P.nigrum and P.longum. ...

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Simultaneous Quantification of Embelin, Piperine and Gallic Acid in Vidanaga Vati by High- Performance Liquid Chromatography

... Decreased serum Cp levels have been positively correlated with a decrease in dopamine transporter density in patients with Parkinson [63]. Cp acts as a defense mechanism against inflammation [64]. Neurodevelopmental disorders such as ASD are closely related with neuroinflammation [65]. ...

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A Comparison of the Treatment Effects of a Risperidone Solution, an Equal Ratio of DHA/ARA, and a Larger Ratio of Omega-6 PUFA Added to Omega-3 PUFA: An Open-Label Clinical Trial

... (family: Sapotaceae) is a large and tall tree commonly known as 'Quixaba', 'Quixabeira', 'Tranceporteira', 'Sacutiaba' and 'Rompe-gibao' in northeastern Brazil. It naturally grows from north of Minas Gerias to Piaui (41). An unsaturated triterpene acid named bassic acid, isolated from the ethanol extract of root bark of B. surtorum exhibited significant hypoglycemic activity in alloxan induced diabetic rat models. ...

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Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

... The pancreas of 4 groups of alloxan diabetic rats treated with MCE (150 mg/kg and 300 mg/kg), glibenclamide (4 mg/kg) and 1% CMC (10 ml/kg) respectively, for a period of 30 days and one group of normal control rats were isolated and preserved in 10%(v/v) formalin. Histopathological evaluation of the tissues [14] was carried out at clinico-pathology laboratory, Haffkine Institute, Mumbai, India. The histological effects were transformed into numerical scoring system and finally expressed in terms of mean ± SEM Evaluation of hypolipidemic activity of MCE in old obese rats A group of 24 old obese male albino Wistar rats [14] were divided into 3 groups of 8 animals each. ...

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An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract

... This result may be attributed to BP's reduction of acetyl-CoA production, which is required for fat metabolism. Studies on animals have demonstrated that the bioactive components of BP, especially piperine, have antiperoxidative effects (Dhuley et al., 1993). Because of this, broiler hens' diets supplemented with BP caused lower levels of plasma cholesterol and LDL cholesterol (Galib et al., 2011;Ghaedi et al., 2014;Shahverdi et al., 2013;Puvaca et al., 2014), which could be attributed to BP antioxidative properties. ...

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Use of black pepper oil in growing-quail diets and its impact on growth, carcass measurements, intestinal microbiota, and blood chemistry

... Of critical importance for successful use of polyene macrolide antibiotics (PMAs) for nonmedical application such as lucensomycin [28], tetramycin [29], aureofungin [30,31], etc. as highly effective fungicides is not only a broad spectrum of antifungal action but also fast and easy degradation to nontoxic compounds after use. This suggests eco-friendliness and expedience of the practical application of perimycin. ...

Reference:

Heptaene Macrolide Antibiotic Perimycin: Preparation, Physicochemical Properties, Structure, Biological Activity, and Application in Agriculture as an Eco-Friendly Fungicide (A Review)