S M Edworthy's research while affiliated with The University of Calgary and other places

Publications (41)

Article
Full-text available
Objective: To examine disease activity versus treatment as lymphoma risk factors in systemic lupus erythematosus (SLE). Methods: We performed case-cohort analyses within a multisite SLE cohort. Cancers were ascertained by regional registry linkages. Adjusted HRs for lymphoma were generated in regression models, for time-dependent exposures to im...
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Criteria for the classification of giant cell (temporal) arteritis were developed by comparing 214 patients who had this disease with 593 patients with other forms of vasculitis. For the traditional format classification, 5 criteria were selected: age greater than or equal to 50 years at disease onset, new onset of localized headache, temporal arte...
Article
Criteria for the classification of Takayasu arteritis were developed by comparing 63 patients who had this disease with 744 control patients with other forms of vasculitis. Six criteria were selected for the traditional format classification: onset at age less than or equal to 40 years, claudication of an extremity, decreased brachial artery pulse,...
Article
Criteria for the classification of hypersensitivity vasculitis were developed by comparing 93 patients who had this disease with 714 control patients with other forms of vasculitis. For the traditional format classification, 5 criteria were selected: age greater than 16 at disease onset, history of taking a medication at onset that may have been a...
Article
The Illness Intrusiveness Ratings Scale (IIRS) measures the extent to which disease or its treatment or both interfere with activities in important life domains. Before comparing IIRS scores within or across groups it is crucial to determine whether a common underlying factor structure exists across patient populations. To investigate the factor st...
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Internet, Telematics and Health Volume 36 Studies in Health Technology and Informatics Edited by: M. Sosa-Iudicissa, N. Oliveri, C. Gamboa and J. Roberts 1997, 556 pp., hardcover plus ISBN: 978-90-5199-289-2
Article
Webcrawling, like pubcrawling, can be dangerous for the uninitiated. Most of the health information on the Web available to patients with arthritis about their disease is profit driven, produced by companies selling product or by individuals with no clear affiliation with a knowledge organization such as a university or a rheumatology association....
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This chapter addresses the issues associated with self-management in arthritis care. Alternative approaches to traditional medical care have gained popularity in the past decade. Some of the factors that have led to this are discussed in this chapter, including personal self-determination, the patient as consumer in a global economy, the backlash a...
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Our objective was to investigate whether quality of life in systemic lupus erythematosus (SLE) differs across ethnoracial groups and to identify factors that may explain race-related differences. Self-administered questionnaire data from 335 White, 40 Black, and 30 Asian women with SLE were obtained from a multi-center database. Measures assessed i...
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To evaluate the effectiveness of a computer assisted educational intervention to facilitate appropriate utilization of an antiinflammatory medication (Arthrotec) and investigate the mechanism by which it produces these effects. A double blind, multicenter, randomized, controlled trial studied patients over age 50 years with hip or knee osteoarthrit...
Article
The Internet provides new opportunities to gather information on the population and may provide alternatives to the traditional methods of conducting clinical trials in systemic lupus erythematosus. The ‘world wide web-www’ has grown extensively in the past decade and it is estimated that there will be over 1 billion individuals on the net by the y...
Article
This study was a blinded, concurrent assessment of a historical cohort derived from a provincial registry (1978 to 1986) of breast implant recipients (cosmetic, not reconstructive) and controls (other cosmetic surgery) to test the hypothesis that connective tissue disease (CTD) is increased in breast implant recipients. Women who underwent breast i...
Article
To assess the utility of an exercise program, which included aerobic, flexibility and strengthening elements, in the treatment of fibromyalgia (FM). FM is a chronic musculoskeletal condition characterized by diffuse musculoskeletal pain and aching. It has been suggested that aerobic exercise is helpful in its treatment. We studied 60 patients who m...
Article
The safety and efficacy of low-dose (10 mg) recombinant human tissue plasminogen activator (rhtPA: Activase: Genentech) was studied in 14 systemic sclerosis (SSc) patients. The patients were enrolled in a double blind, placebo-controlled crossover trial. Patients who met the inclusion criteria were enrolled in the study, given placebo or rhtPA, and...
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To develop a questionnaire for measuring patients' knowledge about arthritis and its self-management. An initial item pool of 175 multiple-choice questions was developed, based on the Stanford Arthritis Self-Management Program and on basic medical knowledge about arthritis and its management. A rheumatologist, psychologist, physiotherapist, and sev...
Article
Connective tissue diseases (CTDs) typically have a wide spectrum of symptoms that vary widely over time, often requiring a large array of medications and laboratory tests. This presents a challenge in all stages of database development, including the selection of data elements, collection methods, coding of variables, and selection of a relational...
Article
To compare the relative efficacy and tolerability of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia, and to identify predictors of response to amitriptyline and cyclobenzaprine. Two hundred eight patients who fulfilled the American College of Rheumatology criteria for the classification of fibromyalgia were entered int...
Article
Illness intrusiveness derives from illness-induced lifestyle disruptions that interfere with continued involvements in valued activities and interests and is hypothesized to represent a fundamental determinant of the psychosocial impact of chronic conditions. The present investigation compared reported levels of illness intrusiveness across 305 ind...
Article
The prescription drugs procainamide (PA) and hydralazine (HYD) are associated with the induction of autoimmunity and a clinical syndrome called drug-induced lupus. Since PA- and HYD-induced autoantibodies are directed primarily against histones and histones are prime acceptors of poly (ADP-ribose) (PADPR), we have investigated the effects of PA and...
Article
Assessment of therapy in patients with rheumatoid arthritis is important but difficult. We examined 4 different methods of analyzing pretreatment data and assessed the difference that each made in detecting a positive effect of intramuscular gold on the patient's overall disability. The methods were (1) calculating the arithmetic mean of prior data...
Article
We report the occurrence of life threatening upper airway complications in 4 of 158 patients with systemic lupus erythematosus (SLE) admitted to our hospital over a 6-year period and review published reports on this complication. The patients included in our study were identified through a computer search of our hospital medical records. Patients'...
Article
Depressive symptoms in rheumatoid arthritis (RA) were hypothesized to derive from illness intrusiveness--illness-induced lifestyle disruptions. Differences over the adult lifespan were also investigated in 110 outpatients with RA, aged 24-78 years who completed standardized psychological tests. A significant Age x Illness Intrusiveness interaction...
Article
This case report concerns a young woman with systemic lupus erythematosus who presented with a protein-losing enteropathy. Intestinal biopsy revealed lymphangiectasia. Mesenteric lymph nodes showed paracortical lymphoid depletion and multiple small sinusoids. Elevated cholesterol levels and normal lymphocyte counts characterized the peripheral bloo...
Article
Criteria for identifying Henoch-Schönlein Purpura (HSP) and distinguishing HSP from other forms of systemic arteritis were developed by comparing the manifestations in 85 patients who had HSP with those of 722 control patients with other forms of vasculitis. By the traditional format of choosing different combinations of candidate criteria and comp...
Article
The American College of Rheumatology Subcommittee on Classification of Vasculitis of the Diagnostic and Therapeutic Criteria Committee developed classification criteria for 7 forms of vasculitis: polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, hypersensitivity vasculitis, Henoch-Schönlein purpura, giant cell (temporal) arter...
Article
Criteria for the classification of Churg-Strauss syndrome (CSS) were developed by comparing 20 patients who had this diagnosis with 787 control patients with other forms of vasculitis. For the traditional format classification, 6 criteria were selected: asthma, eosinophilia >10% on differential white blood cell count, mononeuropathy (including mult...
Article
Criteria for the classification of hypersensitivity vasculitis were developed by comparing 93 patients who had this disease with 714 control patients with other forms of vasculitis. For the traditional format classification, 5 criteria were selected: age >16 at disease onset, history of taking a medication at onset that may have been a precipitatin...
Article
We defined a clinical staging of renal function in systemic lupus erythematosus (SLE) which uses inexpensive outpatient measures to serially stage patient status and then analyzed the disease course of 292 patients followed since 1968. The 4 mutually exclusive states used were (1) normal (creatinine less than 1.2 mg/dl and protein less than 2+ on d...
Article
The 339 cases of systemic lupus erythematosus (SLE) and controls used in 1982 to develop the current ARA rules for classifying this disease were further analyzed using recursive partitioning methodology. The method identified 9 subgroups of cases and controls. It allowed correct classification of 97% of cases and 95% of controls while using only 6...
Article
The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA). The new criteria are as follows: 1) morning stiffness in and around joints lasting at least 1 hour...

Citations

... Several studies have indicated that SPRA patients experience greater disease severity in terms of disease activity, functional impairment, increased mortality over time (2,3), and might show poor response to treatment compared to seronegative RA (SNRA) patients (4). Although both SPRA and SNRA fulfill the 1987 American College of Rheumatology (ACR) revised classification criteria (5) or the 2010 ACR/European League Against Rheumatism (EULAR) classification criteria (6), their clinical manifestations, courses, and prognostic features are distinctive. ...
... Fiftyone, of a total of 2430 patients registered between October 2014-April 2021, were included in this study (Fig. 1). Vasculitis-mimickers (atherosclerosis, peripheral vascular disease, malignancies, tuberculosis, syphilis and other infections), Takayasu's arteritis (ACR 1990 criteria) and Giant Cell Arteritis (ACR 1990 criteria) were excluded (8)(9)(10). This retrospective single-center study included 51 patients aged ≥18 years diagnosed with CP. ...
... Cancer risk was found to have increased in SLE patients in comparison to the entire population. This was more prevalent with patients of white race and younger patients as well as those with lower SLE span [12]. ...
... Magnetic resonance imaging revealed no dural thickening related to hypertrophic pachymeningitis. The patient was diagnosed with EGPA as her condition matched the characteristic clinical course described by the American College of Rheumatology classification criteria [4] with symptoms due to vasculitis following asthma and elevated eosinophils in the peripheral blood. Figure 2A shows the patient's clinical course. ...
... At least three of five criteria must be present to diagnose leukocytoclastic vasculitis with a sensitivity of 71% and specificity of 83.9%. 22 The present case scored 5 out of 5, which favours the diagnosis of leukocytoclastic vasculitis. ...
... If the questionnaire assessment or the laboratory markers either individually or collectively yielded a pathological result, (3) MSUS was conducted and (4) the participant was then directly referred to a board-certified rheumatologist for an initial consultation and if necessary, for further follow-up visits in an outpatient rheumatology clinic. RA was defined by fulfilling the ACR/EULAR classification criteria 1987 [19]. The study was conducted in agreement with the principles of the Declaration of Helsinki, the International Conference on Harmonization Guidance for Good Clinical Practice and approved by local ethic committee of Heinrich-Heine-University Düsseldorf (3249). ...
... To date, preliminary results, controlling for disease activity, support a possible increased risk of lymphoma in cyclophosphamide users, without definitively demonstrating an increased risk for any other medications (adjusted for demographics and disease activity, the odds ratio for cyclophosphamide was 1.99, 95% CI: 1.00-3.96) [42]. More detailed analyses specifically looking at dose, routes and scheduling are underway. ...
... It includes diversified forms of healthcare communication, such as telemedicine, internet-based inquiry and interrogation, online-therapy, and the use of apps and software to trace and collect abundant medical information. Existing studies highlight the vital role of e-health for healthcare in both developed (e.g. the use of internet health) and developing countries (e.g. the use of telemedicine) (Edworthy, 2001;Reiners, Sturm, Bouw, & Wouters, 2019;Suziedelyte, 2012). ...
... Among rheumatic autoimmune diseases, this association has been demonstrated particularly in SS, the CTD with the highest risk of lymphoma [5], as well as in other rheumatic diseases [6]. Increased disease activity has been associated with a higher risk of lymphoma in RA [7], whereas such an association is less clear in SLE [8]. Moreover, a biphasic cancer incidence has been observed in SSc, with a first peak occurring early in the disease, suggesting a paraneoplastic phenomenon in which mutant cells serve as autoantigens. ...
... Tsunoda et al., [5] reported one case where SLE was revealed with dysphonia, while Korbet et al., [6] described a case of dysphonia, foreign body sensation and respiratory difficulties that occurred during SLE. Martin et al., [7] performed tracheotomy in 2 of their 4 patients with acute respiratory distress syndrome. Burgess and Render [8] reported a case in which the patient had a hoarse voice and dysphagia due to SLE-associated laryngopharyngitis. ...