S L Primack’s research while affiliated with Oregon Health & Science University and other places

Blunt injuries of the thorax are common worldwide, their frequency matched by penetrating injuries in the United States. Patients not directed immediately to the operating room by the presence of shock or by findings on chest radiograph and ultrasound undergo CT imaging. CT has played an essential role in changing management of blunt aortic injuries and is the principal means of detecting both blunt and penetrating injuries of the diaphragm. While those pneumothoraces and contusions detected only by CT (radiographically occult) may not be clinically significant, CT detection of esophageal, central airways and cardiac injuries can be lifesaving. Recognition of chest wall injuries on CT not only aids management of the orthopedic trauma but can draw attention to associated sites of neurologic or vascular injuries needing surgical or endovascular treatment.

Chest radiography serves a crucial role in imaging of the critically ill. It is essential in ensuring the proper positioning of support and monitoring equipment, and in evaluating for potential complications of this equipment. The radiograph is useful in diagnosing and evaluating the progression of atelectasis, aspiration, pulmonary edema, pneumonia, and pleural fluid collections. Computed tomography can be useful when the clinical and radiologic presentations are discrepant, the patient is not responding to therapy, or in further defining the pattern and distribution of a radiographic abnormality. Copyright © 2015 Elsevier Inc. All rights reserved.

Purpose: Narrow PTV margins and steep dose gradients underscore the importance of evaluating breathing-associated tumor motion for lung SBRT. The specific aim of this study was to determine the impact of anatomic tumor location on inter-fraction tumor motion. Methods and materials: Forty-one patients underwent standard free-breathing 4DCT simulation and daily image-guidance 4DCTs during lung SBRT. Absolute tumor motion amplitude in the mediolateral (ML), anterior-posterior (AP), and superior-inferior (SI) directions was analyzed from 159 total 4DCT scans (simulation and daily pre-treatment). Results: Overall, the inter-fraction tumor motion amplitude in the ML, AP, and SI directions was small (mean ≤2.5 mm). Similarly, while both upper lobe (UL) and lower lobe (LL) tumors exhibited limited inter-fraction motion in both the ML and AP directions (mean ≤2.2 mm), tumors in the LL had increased inter-fraction motion in the SI direction compared to UL tumors (mean 4.3±4.0 mm vs. 1.7±1.7 mm, p=0.008). Moreover, 28.6% (n=4) of LL tumors exhibited mean inter-fraction motion along the SI direction >5 mm (all of which resided in the supra-diaphragmatic basal segments of the LL). Conclusions: Mean inter-fraction tumor motion amplitude along the SI direction exceeded our PTV margins (an isotropic 5 mm expansion of the ITV) in 28.6% of LL tumors (all of which resided in the basal segments). These results suggest that typical ITV-to-PTV margins may be insufficient for a subset of LL lesions and that increased PTV margins, daily breathing motion re-assessment and/or adaptive re-planning may benefit patients with supra-diaphragmatic tumors in the LL.

Chest radiography serves a crucial role in imaging of the critically ill. Its uses include diagnosis and monitoring of commonly encountered pulmonary parenchymal and pleural space abnormalities. It is also important in evaluating monitoring and support devices and associated complications. CT, another useful imaging modality in select patients, can better characterize pulmonary parenchymal and pleural space disease.

We describe a direct and accurate method for defining chest radiographic anatomy and use this method to delineate the anatomic composition of the right mediastinal border in an adult population. Intravenous contrast-enhanced computed tomographic scans of the chest and accompanying scout tomograms from 99 adults without previously known or detected cardiopulmonary disease that could potentially distort mediastinal, cardiac, or pulmonary anatomy were retrospectively evaluated. Transverse CT images through the mediastinum were directly referenced to the respective acquisition location on the scout tomogram via the acquisition reference line. The anatomic composition of the right mediastinal border on the scout tomogram was determined by drawing a vertical line tangential to the most lateral right mediastinal structure in each transverse CT image. The lengths and relationships of these structures were tabulated. These results will help to create a consensus among radiologists and other clinicians regarding radiographic anatomy, allowing improved localization of mediastinal pathology and enabling more optimal positioning of vascular and cardiac support devices.

Although elevation of the diaphragm can be appreciated on conventional PA and lateral chest radiography, the modality is commonly viewed as inadequate to differentiate diaphragmatic paralysis from eventration. Our objective was to qualitatively and quantitatively measure the utility of chest radiography in determining the presence or absence of diaphragmatic paralysis in patients with an elevated diaphragm. A retrospective analysis of chest radiographs in 32 patients, whom underwent fluoroscopic sniff test for elevated diaphragm, was performed. Diaphragm function was graded by a senior radiology resident, as either "paralyzed" or "non-paralyzed," based on appearance/shape of elevated hemidiaphragm on PA and lateral radiograph. The diaphragm position and shape for all patients were determined using measurements relating to skeletal structures and radius of curvature, respectively. These results were correlated with the results of the fluoroscopic sniff tests. Of 32 patients with elevated diaphragm on chest radiograph, 17 had diaphragmatic paralysis confirmed with fluoroscopic sniff test. Our results indicate that the radius of curvature or shape of the diaphragm on lateral chest radiograph is the most important factor for detection of the presence or absence of diaphragmatic paralysis. HH/APD > 0.28 suggests against paralysis. Conventional chest radiography appears to be a useful modality for assessment of the functional status of an elevated diaphragm. Based on our results, evaluation of the shape of an elevated diaphragm may preclude the need for fluoroscopic sniff test to determine diaphragmatic paralysis.

Mycobacterium tuberculosis infection in non-human primates parallels human tuberculosis, and provides a valuable vaccine evaluation model. However, this model is limited by the availability of real-time, non-invasive information regarding disease progression. Consequently, we have combined computed tomography scanning with enumeration of antigen-specific T cell responses. Four rhesus monkeys were infected with M. tuberculosis strain H37Rv (1000 cfu) in the right lower lobe via a bronchoscope. All uniformly developed progressive tuberculosis, and required euthanasia at 12 weeks. Computed tomography scanning provided detailed real-time imaging of disease progression. At necropsy, computed tomography and pathohistologic findings were tightly correlated, and characteristic of human disease. Immunologic monitoring demonstrated progressive evolution of high frequency M. tuberculosis-specific CD4(+) and CD8(+) T cell responses. Peripheral blood effector cell frequencies were similar to those observed in tissues. In summary, computed tomography scanning in conjunction with immunologic monitoring provides a non-invasive, accurate, and rapid assessment of tuberculosis in the non-human primate.

Traumatic pulmonary parenchymal injuries demonstrate a characteristic appearance in distribution, morphology, and temporal evolution on the chest radiograph and CT that often allows the radiologist to provide a narrow differential or definitive diagnosis. Accurate, focused diagnosis on the part of the radiologist can significantly aid the trauma surgeon/clinician in tailoring treatment and appropriate follow-up to optimize patient care with reduction in morbidity and mortality.