S. Ignacimuthu's research while affiliated with St. Xavier's College, Palayamkottai and other places

Publications (392)

Article
Glycyrrhetinic acid (GA) is one of the important Pentacyclic Triterpenoids (PT) found in the roots of licorice. This study aimed to evaluate the in vitro growth inhibitory effect of 18β-GA (18β-Glycyrrhetinic acid) and C-30 esters against Theileria annulata, the causative agent of Tropical Bovine Theileriosis. C-30 esters of 18β-GA were synthesized...
Article
The present study introduces an effective and rapid method for isolation of antifungal compound ricinine from Ricinus communis (L.). In this respect, the tender leaves of R. communis were extracted using methanol and tested for antifungal activity against a panel of dermatophytes and plant pathogenic fungi. Primarily, the total extract exhibited br...
Article
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Main conclusion Identification of molecular markers and characterization of nutrient transporters could help to improve the tolerance under abiotic and low nutrient stresses in sorghum ensuring higher yield to conserve food security Abstract Sorghum is an important cereal crop delivering food and energy security in the semi-arid tropics of the wor...
Research
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The stems of Begonia malabarica Lam. (Begoniaceae) is used as a food supplement and remedy for diabetes by the Malasar tribes in Tamil Nadu. The work assessed the protective effect of a bioactive fraction from B. malabarica on pancreatic β-cells of Multiple Low Dose of Streptozotocin (MLDS) induced diabetic mice. The animals were treated orally eit...
Chapter
The demand for more food and the prevalence of malnutrition are the major issues affecting people in several developing countries. Finger millet, (Eleusine coracana [L.] Gaertn). is a minor cereal with rich sources of nutraceuticals as compared to other regularly consumed major cereals. Finger millet is considered as a staple food for millions of p...
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Streptomyces is one of the most prolific producers of economically important bioactive compounds used against several illnesses; it has also been found to produce industrially useful enzymes. In this study, Streptomyces sp. (ERINLG-201) was isolated from the soil sample of Kodanad forest (Southern Western Ghats), The Nilgiris, Tamil Nadu, India. ER...
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Phosphorus (P), absorbed from soil solutions as inorganic phosphate (Pi), is a limiting nutrient for plant growth and yield. Twenty genotypes of foxtail millet (Setaria italica) with contrasting degree of growth and Pi uptake responses under low Pi (LP) and high Pi (HP) supply were chosen based on a previous study. To gain molecular insights, expre...
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Finger millet (Elusine coracana) in an important nutria-rich cereal crop. A total of 42 Indian genotypes were used to identify quantitative trait loci (QTL) associated with root traits (root length and root weight) and biochemical parameters (activities of catalase (CAT), ascorbate peroxidase (APX), glutathione reductase (GR), peroxidase (POD), and...
Chapter
Chitosan has been shown to possess several exceptional potentials due to its excellent physicochemical properties; in spite of this, native chitosan has been found to have only limited use. Hence, there is a need to modify the structure of native chitosan using various biotechnological applications to make it more promising. Chitosan is unique with...
Article
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Food insecurity is a looming threat for the burgeoning world population. Phosphorus (P), which is absorbed from soil as inorganic phosphate (Pi), is an essential macronutrient for the growth of all agricultural crops. This study reports phenotype analysis for P responses in natural field and greenhouse conditions, using 54 genotypes of foxtail mill...
Article
Background Systemic lupus erythematosus (SLE) is an autoimmune disease prevalent among humans. SLE's down-regulation of T and B lymphocytes causes the development of autoantibodies, which in turn attack the molecules present in cell surface, nucleus, and cytoplasm, creating immune complexes that harm tissues. Objective The objective of this review...
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Selection of an appropriate hybridization method and use of molecular markers to study genetic purity of hybrids are important factors in crop improvement. In this study, our objective was to analyze two emasculation methods in finger millet and to present a strategy for the assessment of the genetic purity of F1 hybrids using molecular markers. Tw...
Article
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Selection of an appropriate hybridization method and use of molecular markers to study genetic purity of hybrids are important factors in crop improvement. In this study, our objective was to analyze two emasculation methods in finger millet and to present a strategy for the assessment of the genetic purity of F 1 hybrids using molecular markers. T...
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Borassus flabellifer L. is a tall palm traditionally used for its stimulating, diuretic and anti-inflammatory activities; it is rich in fibers and various pharmacologically important secondary metabolites. This study was undertaken to evaluate the antidiabetic effects of Borassus flabellifer fruit methanol extract (BF-M) on diabetic rats induced wi...
Article
To evaluate the bioefficacy of crude extract and fractions from the leaves of Couroupita guianensis Aubl. against second and fourth instar larvae of Culex quinquefasciatus Say and Aedes aegypti L. The phytochemical parameters of hexane extract derived fraction were analyzed. Chromatographically enriched fractions from hexane extract were eluted by...
Article
Ethnobotanical relevance: The interest on herbal health supplements for obesity is increasing globally. Our previous ethnobotanical survey in Tiruvallur district, Tamil Nadu, India indicated the use of Spermacoce hispida L. seeds for the treatment of obesity. Aim of the study: This study was aimed to validate the traditional claim and to identify t...
Preprint
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Phosphorous (P) is an important macronutrient for the growth of all agricultural crops. This study reports phenotype analysis for P responses in field (two different seasons, monsoon and summer) and greenhouse, using 54 genotypes of foxtail millet ( Setaria italica ) under P-fertilized (P+) and unfertilized (P-) conditions. Variation was seen for p...
Article
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Background: Siddha is one of the traditional medical systems of India; previous ethnobotanical survey in Virudhunagar district indicated a high consensus for treating musculoskeletal ailments. Objectives: This study was aimed to quantitatively document the medicinal plants used to treat musculoskeletal ailments by non-institutionally trained sid...
Article
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Traditional knowledge extends to an appreciation of both the material and non-material properties of plants and animals. In countries like India and China, traditional health systems are firmly rooted in long-standing cultural and spiritual values [1]. Herbal medicine is largely used for various human illness and the usage of the medication began f...
Chapter
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Recent studies have revealed the remarkable position of naturally derived polymeric biomaterials in science and technology. These biomaterials with wide array of applications in science are transforming the quality of life. Chitosan is a deacetylated derivative of chitin, an important naturally occurring linear polysaccharide. The amino group of ch...
Article
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Crude extracts of 17 medicinal plants were examined for their antifungal properties against phytopathogenic fungi. Hexane, chloroform and methanol extracts were tested using disc diffusion method at concentrations varying from 1.25 to 5 mg/ disc. Among these, hexane extract of Blumea mollis was the most effective against Aspergillus flavus with zon...
Article
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Non-alcoholic steatohepatitis (NASH) is one of the aggressive forms of non-alcoholic fatty liver disease (NAFLD) and is a potential risk factor of HCC. This study reports the curative effect of tiliamosine on NASH. Tiliamosine was isolated from Tiliacora racemosa Colebr. (Menispermaceae) and its structure was confirmed by studying the physical and...
Article
The cross-genome transferability of 101 simple sequence repeats (SSR) markers of finger millet and 26 SSR markers of foxtail millet were analyzed in 8 other millets. In total, 33 finger millet and 2 foxtail millet SSR markers showed 100% cross-genome transferability in other millets. The cross-genome transferability of 101 finger millet and 26 foxt...
Article
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Background: Medicinal properties of the food species are one of the poorly documented and important areas of ethnopharmacology. The present survey quantitatively documented the medicinal foods prescribed by the non-institutionally trained siddha practitioners of Tiruvallur district of Tamil Nadu. Methods: Field work was carried out between Decem...
Article
The present study was aimed to isolate bioactive actinomycetes with antifungal properties. Twenty-seven distinct soil derived actinomycetes were investigated for their antifungal activities. Among these, one isolate exhibited significant antifungal activity. Phenotypic and 16s rRNA gene sequence analysis strongly suggested that the active isolate B...
Article
The Drug-induced liver injury is one of the common unfavourable impacts, which seriously affects any drug therapy. This study documented the hepatoprotective efficacy of lawsone, the major bioactive naphthoquinone present in Lawsonia inermis L. (Lythraceae) using in vitro and in vivo models. Lawsone was isolated from the leaves of L. inermis and it...
Article
Objective: Dermatophytes are resistant to some available antibiotics. Development of new plant drugs to control drug resistant microbes is urgently needed. This study evaluates the antidermatophytic potential of 18 selected medicinal plants used by traditional healers in Theni and Virudhunagar Districts of Tamil Nadu, India. Materials and methods...
Article
Okra is an important vegetable crop and very few studies have been carried out for the development and in vitro regeneration of somatic embryos. In this study, we have developed an efficient protocol for somatic embryogenesis from cotyledonary leaf explants of Okra (Abelmoschus esculentus L. Monech). In this investigation, the genotype CoBhH1 of A....
Article
Laryngeal carcinoma is the second commonest and most aggressive cancer originating in the squamous cells of the laryngeal epithelium. Undesirable complications and resistance to chemotherapy are the common problems which necessitate the development of alternative anticancer agents for the management of laryngocarcinoma. We herein report the biosynt...
Article
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Phosphate is an essential nutrient for plant growth and is acquired from the environment and distributed within the plant in part through the action of phosphate transporters of the PHT1 family. Foxtail millet (Setaria italica) is an orphan crop essential to the food security of many small farmers in Asia and Africa and is a model system for other...
Article
Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete adjuvant (FCA) induced in-vivo...
Article
In this study, we have attempted to isolate and characterize the extracellular lipase from Streptomyces sp. Actinomycetes strains were isolated from the soil collected from the Vedanthangal bird sanctuary. Further, the isolated strains were subjected to lipase enzyme activity. Lipase activity was determined for isolated pure colonies by using pepto...
Article
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Zinc (Zn) deficiency causes large scale yield losses in major crops such as rice, wheat and maize. Zn is an important micronutrient and the only metal ion acting as a co-factor for all six classes of enzymes in plants and other organisms. In this review, we have identified the phenotypic and biochemical changes associated with Zn deficiency in plan...
Article
The prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing and there is an increasing interest in natural products to treat NAFLD. This study aimed to evaluate the hepatoprotective effect of andrographolide and two of its derivatives; in one the OH group at C-14 was removed and in the other OH groups at C-3 and C-19 were protected. A...
Data
The mean values of seedling stage P response in finger millet genotypes. (PDF)
Data
The details of hits obtained with original sequences of QTLs UGEP13, UGEP19, UGEP68 and UGEP90 during cross genome synteny of ten species from grass family such as Oryza sativa, Brachypodium distachyon, B. stacei, Panicum hallii, P. virgatum, Setaria italica, Setaria viridis, Sorghum bicolor, Zea mays and Triticum aestivum. (PDF)
Data
Genotypes matrix showing low P tolerant responses for different combinations of traits in which shorter root length under Pdef was used as low P response. (PDF)
Article
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A germplasm assembly of 128 finger millet genotypes from 18 countries was evaluated for seedling-stage phosphorus (P) responses by growing them in P sufficient (Psuf) and P deficient (Pdef) treatments. Majority of the genotypes showed adaptive responses to low P condition. Based on phenotype behaviour using the best linear unbiased predictors for e...
Article
One of the important aims of drug discovery for cancer is to find therapeutic agents from natural products that are effective and safe for cancer treatment. In the current study, an alkaloid, 2-acetyl-benzylamine, isolated from Adhatoda vasica, was screened for potent anticancer properties against leukemia cells. We used seven different types of le...
Article
Chitosan has been considered as a chelating agent with the potential for the adsorption of dyes, metal ions and proteins. This study was aimed to prepare and characterize different fungal chitosan nanoparticles (FCI-1 to FCI-6 NPs) by ionic gelation method and to evaluate its efficacy on the sorption of various commercial dyes. Morphological observ...
Article
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Objective: The present study was undertaken with the aim of finding out the efficacy of essential oils (EOs) as anti-mosquito agents for commercial purposes. Plant source insecticides as an alternative to chemical insecticide, this study were evaluated to assess the knock-down and adulticidal prospective of the essential oils against Culex quinquef...
Article
Systematic analyses of plants that are used in traditional medicine may lead to the discovery of novel cytotoxic secondary metabolites. Diterpene possesses multiple bioactivities; here, epoxy clerodane diterpene (ECD) was isolated from Tinospora cordifolia (Willd.) stem and shown potential antiproliferative effect in MCF-7 human breast cancer cells...
Article
A fumigant toxicity tests were performed by using airtight plastic jars, in which five small glass tubes with perforated lids containing 20 cowpea seeds and four newly emerged Callosobruchus maculatus were placed. Filter paper impregnated with an appropriate volume (5, 10, 20, 40 μl/ml) of the oils were attached to the lower surface of the jar lid....
Article
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This study investigated the anticariogenic effect of 14 crude extracts from 7 medicinal plants and one isolated molecule on survival and growth of selected cariogenic bacteria. Antibacterial activity was performed against the selected organisms by disc diffusion method; minimum inhibitory concentration (MIC) was determined for purified compound. Th...
Article
The gum of Gardenia resinifera Roth., is one of the important drugs used in the Indian system of medicine and a source of unique polymethoxylated flavones. This study was aimed to evaluate the antihyperlipidemic and anti-NAFLD effects of Gardenin A (Gar-A) from G. resinifera gum using in vitro and in vivo models. Gar-A was isolated from G. resinife...
Article
Actinomycetes are one of the most important groups that produce useful secondary metabolites. They play a great role in pharmaceutical and industrial uses. The search for antibiotic producing soil actinomycetes to inhibit the growth of pathogenic microorganisms has become widespread due to the need for newer antibiotics. The present work was aimed...
Article
Full-text available
In this study, we have attempted to isolate and characterize the extracellular lipase from Streptomyces sp. Actino-mycetes strains were isolated from the soil collected from the Vedanthangal bird sanctuary. Further, the isolated strains were subjected to lipase enzyme activity. Lipase activity was determined for isolated pure colonies by using pept...
Article
Some actinomycetes were isolated from the soil samples collected from Kanyakumari, Tirunelveli, Dindigul, Coimbatore and the Nilgiri districts of Western Ghats in Tamil Nadu, India. They were screened for antibacterial and antifungal activities. Among the 150 strains of actinomycetes isolated from the soil samples, 21 isolates were active against m...
Article
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We evaluated the genetic variation and population structure in Indian and non-Indian genotypes of finger millet using 87 genomic SSR primers. The 128 finger millet genotypes were collected and genomic DNA was isolated. Eighty-seven genomic SSR primers with 60-70 % GC contents were used for PCR analysis of 128 finger millet genotypes. The PCR produc...
Article
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Keywords Bioassay, chikungunya, dengue, lymphatic filariasis, vector control Correspondence The mosquitocidal activities of different fractions and a compound alizarin from the methanol extract of Rubia cordifolia roots were evaluated on larvae and pupae of Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae). Larvae and pupae wer...
Article
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The plant PHosphate Transporter 1 (PHT1) family of membrane proteins belong to the Major Facilitator Superfamily (MFS) and play a major role in the acquisition of inorganic phosphorus (Pi) from the soil and its transport within the plant. These transporters have been well characterized for expression patterns, localization, and in some cases affini...
Data
Tables A-B, (A) Agronomic performance and percentage of disease incidences (PDI) of the 128 finger millet genotypes; the data were collected after 45 and 90 days of sowing the seeds for PDI and agronomic traits respectively; (B) List of 87 genomic SSR primers with primer sequence (5’ to 3’), SSR motif and size of markers (bp) used for the analysis...
Data
Figures A-K, (A) The design layout of the experiment. The test genotypes were grown alternated with resistant and susceptible checks to provide adequate disease load throughout cropping season; (B) Screen shot image of comparative genomics analysis with QTL UGEP50 in genome of foxtail millet. QTL UGEP50 was associated with candidate gene Cytochrome...
Article
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Finger millet is one of the small millets with high nutritive value. This crop is vulnerable to blast disease caused by Pyricularia grisea, which occurs annually during rainy and winter seasons. Leaf blast occurs at early crop stage and is highly damaging. Mapping of resistance genes and other quantitative trait loci (QTLs) for agronomic performanc...
Data
The details of the algorithm parameters such as score value, identity and E-value for each QTL as analyzed in 10 model crops by in silico comparative genomics. File contains separate sheet for each QTL. (XLSX)
Article
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The clustered, regularly interspaced, short palindromic repeat (CRISPR) and CRISPR associated protein 9 (Cas9) system discovered as an adaptive immunity mechanism in prokaryotes has emerged as the most popular tool for the precise alterations of the genomes of diverse species. CRISPR/Cas9 system has taken the world of genome editing by storm in rec...