S D†Epiro’s research while affiliated with Sapienza University of Rome and other places

Hyperhidrosis is a condition characterized by generalized or localized hyperfunction of the eccrine sweat glands with a deep negative impact on patient's quality of life. To evaluate the efficacy and the safety of Botulin Toxin A (BTX-A) intradermal injection in the treatment of primary axillary and palmar hyperhidrosis, investigating symptoms-free period, and the subjective improving of quality life. 50 consecutive patients with primary hyperhidrosis were evaluated detecting age, gender, hyperhidrosis onset period, disease duration and years of treatment with BTX-A, Minor's iodine test, Hyperhidrosis Disease Severity Scale (HDSS), Dermatology Life Quality Index (DLQI). The treatment is significantly effective both for axillae and palms: the majority of the patients improved their HDSS and Minor's scores from a value of 4 in the two tests, to values of 1 (HDSS) and 0 (Minor test). Patients reported a duration of symptoms relief from 4 to 12 months, with a mean of 5.68 months; specifically, we have observed that the axillary group experienced a longer symptoms-free period (mean RFS 7.2 months) than the palmar group (mean: RFS 4.27 months). Authors suggest that BTX-A is a safe, easy, and fast procedure for the treatment of primary axillary and palmar hyperhidrosis.

The aim of our study was to investigate the possible role of nitrogen reactive species in pathogenesis of psoriasis. A total of 187 individuals were included in this study, out of these 84 were patients suffering from psoriasis and 103 were healthy subjects, served as a control. Patients with psoriasis were graded according to the Psoriasis Area Severity Index (PASI), presenting at the time of blood collection. After obtaining prior consent, about 2 ml of random blood was collected for estimation blood free nitric oxide (NO) content by Electron Paramagnetic Resonance (EPR) Spectroscopic method. For detection of NO in blood the spinвЂ"trap (diethilditiocarbamate (DETC) (Sigma) was used. In blood samples of patients with psoriasis nitrosilated hemoglobin (HbNO) complexes and alterations of free spin-trapped NO EPR signal intensity and were detected. Free NO content in blood decreased with the increasing severity of the psoriasis. It may be concluded that under oxidative stress conditions during psoriasis the decrease level of free nitric oxide in the patient’s blood may contribute to a violation of the vasomotor activity of subcutaneous capillaries, impairment of skin blood supply, development of hypoxia, exacerbation of oxidative stress, alteration of immune balance, spreading of skin infection and exacerbation of the severity of psoriasis. Use of NO-containing creams will contribute to a partial recovery of disturbed functions and remission of the disease.