S D Arapova's research while affiliated with Endocrinology Research Centre and other places

Publications (38)

Article
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Aim. To study the clinical, biochemical characteristics, treatment results and follow-up of patients with ectopic ACTH syndrome EAS (ACTH adrenocorticotropic hormone ). Materials and methods. A retrospective, observational, single-center study of 130 patients with EAS. Demographic information of patients, medical history, results of laboratory and...
Article
Osteopetrosis is a rare hereditary disease that develops as a result of genetic mutations leading to impaired development and function of osteoclasts. There are several forms of osteopetrosis that differ in the type of inheritance (autosomal recessive, autosomal dominant and intermediate) and the severity of symptoms. The main clinical manifestatio...
Article
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Background: The registry is the main source of information about patients with acromegaly for assessing the quality of medical care, effectiveness of treatment, determining the compliance of real clinical practice with existing standards and patient management protocols. Aims: To evaluate epidemiological, demographic and clinical characteristics...
Article
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Background. Cushings disease (СD) is а severe neuroendocrine disease that can rapidly progress with the development of severe complications of hypercorticism requiring immediate treatment. The main method of treatment is a neurosurgical operation, the effectiveness of which at the present time can reach 80% or more, however, about a quarter of pati...
Article
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Multiple endocrine neoplasia syndrome type 1 (MEN1, Wermer's syndrome) is a group of heterogeneous inherited diseases, with its pathogenesis related to hyperplasia or neoplasms of several endocrine glands. This syndrome is characterized by autosomal dominant mode of inheritance, high penetrance and similar prevalence among males and females. Preval...
Article
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Background. Cushing’s disease (CD) is the heavy disease of the hypothalamic-pituitary-adrenal axis. The cause of the disease is pituitary adenoma (corticotropinoma). Hypersecretion of ACTH by a pituitary adenoma leads to increased secretion of cortisol by the adrenal cortex and the development of total endogenous hypercortisolism. The gold standard...
Article
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Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after. The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent C...
Article
Phaeochromocytomas are responsible for the development ACTH-ectopic syndrome in 5% cases. Less than 1% phaeochromocytoma accompanied by symptoms of ACTH-dependent hypercortisolism. We observed four cases of ACTH-secreting phaeochromocytoma during 2 years. All patients were women from 50 to 63 years. The disease duration ranged from 6 months to 5 ye...
Article
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Ectopic secretion of ACTH from non-pituitary tumors, referred to as ectopic ACTH syndrome (EAS), accounts for about 10–20% of Cushing’s syndrome (CS). Ectopic hormone-secreting pheochromocytomas (Pheo) are rare. The first publication of association between pheochromocytoma and Cushing’s syndrome by Roux is dated 1955. Pheochromocytoma represents a...
Article
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This study included the patients presenting with neuroendocrine tumours (NET) and the clinical picture of hypercoticism caused by excessive ACTH secretion from the tumour. The overwhelming majority of the patients (85%) suffered Cushing's disease (CD) associated with a pituitary tumour. The remaining 15% of the patients presented with ACTH-ectopic...
Article
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The authors report a rare case of ACTH-ectopic syndrome with the cyclic clinical course and localization of the primary neoplasm in the cecum of the 24-year old woman followed up for 6 years.
Article
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Aims: this study evaluates the most common associations of symptoms and complications in patients with Cushing’s syndrome (CS) in order to choose a potential population to be screened for CS and estimates the diagnostic accuracy of first line screening tests (cortisol, ACTH) to differentiate ACTH-ectopic CS from Cushing’s disease. Materials and Met...
Article
Introduction: Long term remission of CD is achieved in 65–83% after neurosurgery, while the remaining cases have recurrence or continued tumor growth. This paper deals with the problem of CD prognostic factors after neurosurgery. Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline–eosine staining) and...
Article
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Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing’s disease (CD). Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing’s syndrome (CS) (...
Article
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This paper highlights the problem of neuroendocrine tumours (NETs) with clinical symptoms of hypercorticism caused by hypersecretion of adrenocorticotropic hormone (ACTH) by tumour cells. In most cases (85%), the tumours were localized in the pituitary gland (Cushing's disease); 15% of the patients had an extrapituitary tumour that manifest as an e...
Article
The patients in the active phase of endogenous hypercorticism not infrequently present with hypercoagulation syndrome characterized by abnormal blood clotting in conjunction with slowed fibrinolysis, elevated fibrinogen and D-dimer concentrations. In addition, such patients exhibit endotheliosis manifest as a rise in the PAI-1 and Willebrand factor...
Article
Long-standing hypercortisolemia is accompanied by multiple defects of metabolic regulation. Glucocorticoids are known to affect not only metabolic processes but also the vascular wall directly influencing its remodeling and angiogenesis. Syndrome of endogenous hypercorticism is characterized by various disturbances in the hemostatic system and a te...
Article
The present paper deals with late results of the treatment of patients with Cushing's disease by proton beam irradiation of the pituitary gland. Retrospective analysis included results of hormonal assays in 197 patients (161 women and 36 men) with verified Cushing's disease who had undergone proton therapy at the Endocrinological Research Centre. T...
Article
This study was designed to compare immunoexpression of somatostatin receptors (SR)1-5 and dopamine receptors 2 (DR2) in pituitary and non-pituitary ectopic ACTH-producing tumours. A total of 35 patients were enrolled in the study including 21 with Cushing's disease (CD) and 14 with ACTH-ectopic syndrome (ACTH-ES) associated with carcinoid tumours o...
Article
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The purpose of this study was to evaluate the direct action of desmopressin (agonist of vasopressin) on the hypophysis and the three zones of the adrenal cortex in patients with different forms of hypercortisolism. Forty-three patients with hypercortisolism-21 with Cushing's disease (14 females, 7 males), 11 with extrapituitary, ectopic tumours (5...
Article
Aim: To study effects of one-year therapy with bivalos on mineral bone density (MBD) of the spine in patients with postmenopausal osteoporosis (PMO), effects of bivalos (strontium ranelate) on MBD of the neck of the femur and femur, the levels of bone metabolism markers, quality of life, tolerance of long-term therapy. Material and methods: The...
Article
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В представляемой работе обобщен первый опыт применения Бивалоса в терапии ПМО в России. Целью настоящего исследования являлось изучение влияния терапии Бивалосом в течение года на МПК позвоночника, МПК шейки бедра и бедренной кости в целом, уровень маркеров костного метаболизма, а также на качество жизни и переносимость длительной терапии у пациент...
Article
То study the efficiency of neurosurgical treatment of the Itsenko-Cushing disease (1CD), the authors analyzed the early and late results of adenomectomy in 99 patients (90 females and 9 males) with ICD. The diagnosis of ICD was verified on the basis of hormonal studies, functional tests, and the results of topic diagnosis. All the patients had an a...
Article
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The aims of the reported multinational open study were to estimate the influence of subcutaneous injections of 20 mkg daily Teriparatide on bone mineral density (BMD) at the lumbar spine and proximal femur, the markers of bone metabolism, the quality of life as well as the safety of treatment. Duration of the treatment period was one year. Fifty po...
Article
То evaluate the effectiveness and safety of drug treatment for acromegaly, the authors conducted an open-labeled prospective study of the impact of treatment with long-acting octreotide Sandostatm LAR) on the content of growth hormone (GH) and IRF-1 and on the size of a pituitary tumor. The study covered 40 patients (28 females and 12 males) aged 2...
Article
То investigate the direct effect of desmopressin (DP), a vasopressin agonist, on the adrenal cortex, the authors studied a response of the pituitary and all three adrenal cortical areas in patients with different forms ofhypercorticism (active stage): ACTH-dependent Itsenko-Cushing syndrome, ectopic ACTH-dependent syndrome, corticosteroma. The leve...
Article
Adenomectomy was carried out in 41 patients with Icenko-Cushing’s disease. Before surgery, computer-aided tomography showed pituitary adenomas in all the patients. The patients were divided into 2 groups. Group 1 consisted of 31 patients in whom the disease was diagnosed for the first time and group 2 of 10 patients previously treated by other meth...
Article
Adenomectomy was carried out in 41 patients with Icenko- Cushing's disease. Before surgery, computer-aided tomography showed pituitary adenomas in all the patients. The patients were divided into 2 groups. Group 1 consisted of 31 patients in whom the disease was diagnosed for the first time and group 2 of 10 patients previously treated by other met...
Article
Fifty three consecutive patients with Cushing's disease were operated on in the Neurosurgical Institute from 1987 to 1995. In all cases the diagnosis was based on clinical and laboratory data, as well as radiographic images. Ten patients with false-negative CT scans had MRI confirming the presence of microadenomas less than 5 mm in size. The majori...
Article
Full-text available
Microsurgical selective removal of hypophyseal adenomas is more and more frequently used in the treatment of Itsenko-Cushing's disease of late. This permits complete cure of approximately 90% of the patients. Ten patients with this disease, induced by corticotropinoma, were observed. The hormonal methods, as well as computer-aided tomography and NM...

Citations

... В отдельных случаях (25%) после проведенного обследования по органам и системам не удается выявить источник гиперпродукции АКТГ, а состояние пациента прогрессивно ухудшается вследствие гиперкортицизма. Вариант лечения -двухсторонняя адреналэктомия с пожизненной заместительной терапией [11,12]. ...
... населения. Российский регистр опухолей гипоталамо-гипофизарной области объединяет и систематизирует эпидемиологические, демографические и клинические характеристики больных акромегалией [2], что позволяет оценить своевременность диагностики и эффективность различных методов лечения заболевания. Однако большой пул данных не позволяет увидеть все особенности ведения пациентов в различных регионах такой масштабной страны, как РФ. ...
... В связи с этим ведется поиск прогностических критериев развития ремиссии БК после ТСЭА, в качестве ко-торых чаще всего предлагают использовать результаты послеоперационного обследования, а именно оценку уровня кортизола и АКТГ в крови [7,9,10,[11][12][13][14][15][16][17][18]. Проблема заключается в отсутствии общепринятых пороговых значений показателей: в различных исследованиях отрезные точки уровня кортизола сыворотки значительно варьируют -от 50-55, 100, 123, 138-140 нмоль/л до более высоких -284,3, 579,6 нмоль/л [9,[11][12][13][14][15][16][17][18]. ...
... Adult CD patients with USP8 mutant tumours have a higher incidence of recurrence after transsphenoidal adenomectomy and shorter relapse free survival time [28]. The results of our study are consistent with the results of other studies with respect to the fact that morning ACTH and cortisol levels are statistically associated with recurrence and time-to-recurrence [4,18,[29][30][31]. Predictors such as gender, age, duration of disease did not have any separate impact to the probability of recurrence as other authors describe [4,18,29,[31][32][33]. ...
... населення [10,11]. Епідеміологічна ситуація суттєво відрізняється в різних країнах, що можна пояснити, з одного боку, різним рівнем соціальноекономічного розвитку, організації надання медико-фармацевтичної допомоги й ефективності диспансерного спостереження, з іншого -відмінностями щодо забезпеченості кваліфікованими спеціалістами й доступності до медифармацевтичної допомоги [12][13][14][15][16][17][18]. ...
... In addition, a 2008 multicenter trial in Russia analyzed the effect of 1-year administration of strontium ranelate on BMD of patients with postmenopausal osteoporosis. It was found that strontium ranelate increased lumbar vertebra BMD, inhibited local tissue-mediated bone resorption markers, and resulted in improved QOL outcomes, with patients reporting better motility, lowered rates of depression, and improved self-assessments (171). While promising, further studies are needed to determine the impacts of strontium ranelate on mental health and whether or not it may serve as a more suitable treatment option for osteoporotic patients with a history of mental health disorder. ...
... АКТГ-ЭС одинаково распространен как среди мужчин, так и среди женщин [7]. Клиническая картина БИК и АКТГ-ЭС обусловлена в первую очередь проявлениями хронической гиперкортизолемии и характеризуется перераспределением подкожножировой клетчатки, повышением артериального давления, нарушением углеводного обмена, образованием характерных багровых стрий на поверхности передней брюшной стенки, груди, плеч, матронизмом, мышечной слабостью, патологическими переломами костей скелета, ломкостью капилляров (приводящей к легкому образованию кровоизлияний, экхимозов и петехий), нарушением менструальной функции у женщин, снижением потенции у мужчин [8,9]. Несмотря на то что причины гиперпродукции АКТГ разные и тактики лечения, соответственно, тоже, установить диагноз по сумме клинических проявлений и комплекса лабораторно-инструментальных исследований не всегда представляется возможным. ...
... The variables included in the model are reasonable. Hormonal studies [30] showed that EAS was associated with high plasma ACTH and cortisol levels, late-evening salivary cortisol, and daily urinary free Endocrine cortisol, the absence of a 60% or more significant reduction of cortisol in the HDDST test. Our previous work proved that potassium value was significantly higher in EAS than in CD [14]. ...
... AVP-dependent induction of sEH biosynthesis may, therefore, be mediated via the AVP V 2 receptor-dependent activation of adenylyl cyclase VI (56). Other mediators that have been shown to regulate sEH biosynthesis and may interfere with AVP signaling include ANG II (32, 69, 72, 78), steroid hormones (43,55), and PPAR␥ agonists (25,47). ...