S A Swigart's research while affiliated with University of Nebraska Medical Center and other places

Publications (3)

Article
Cimetidine has been reported to cause antiandrogenic effects in male pups of female rats receiving cimetidine during gestation. Because of conflicting reports of cimetidine causing permanent antiandrogenic effects in male rats, we studied the sexual development of male rats born to females receiving cimetidine. Water or water and cimetidine (194 mg...

Citations

... 8 So far few PK studies in neonates treated with vancomycin on ECMO were conducted showing an increased volume of distribution (Vd) and decreased or variable clearance (CL) of vancomycin in comparison with non-ECMO patients. [9][10][11] Perfusion 00(0) PK simulation was performed in a one-compartmental PK model with first-order elimination kinetics using MWPharm ++ software (MediWare, Prague, Czech Republic). 12 The vancomycin population PK model was then individualised to maximise fitting of the simulated PK profile curve with observed concentration points. ...
... Cimetidine crosses the placenta by passive diffusion [38] and has been allocated to pregnancy category B by the FDA, which means that cimetidine is not expected to be harmful to the fetus. There are conflicting reports on antiandrogenic effects of cimetidine in animals exposed in utero61626364; however, no anti-androgenic effects of cimetidine have so far been reported in human pregnancy. We demonstrated that giving cimetidine (100 mg/kg IP twice at an interval of 12 h) to pregnant rats at an early period of neurogenesis did not affect proliferation (Figures 7A, 7B, S7A, and S7B), survival (Figure S8A and S8B), or density (Figure S8C and S8D) of neural progenitor cells in the VZ or SVZ. ...