S. A. Moncada's scientific contributions

Publications (2)

Article
Endothelium-derived relaxing factor (EDRF) is a labile humoral agent which mediates the action of some vasodilators. Nitrovasodilators, which may act by releasing nitric oxide (NO), mimic the effect of EDRF and it has recently been suggested by Furchgott that EDRF may be NO. We have examined this suggestion by studying the release of EDRF and NO fr...
Article
Endothelium-derived vascular relaxing factor (EDRF) is a humoral agent that is released by vascular endothelium and mediates vasodilator responses induced by various substances including acetylcholine and bradykinin. EDRF is very unstable, with a half-life of between 6 and 50 s, and is clearly distinguishable from prostacyclin. The chemical structu...

Citations

... Ferid Murad was awarded the Nobel Prize in Physiology or Medicine in 1998 for his finding on cyclic guanosine monophosphate (GMP) dependence.In his early findings, NO was shown to activate the cytoplasmic isoform of guanylyl cyclase, which catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (GMP). In these circumstances, the increase of GMP level will lead to a series of phosphorylation processes, thereby causing the dilation of blood vessels and the change of blood flow velocity (15). This pathway is known as the GMP-dependent pathway. ...
... 11 In addition, superoxide produced due to pro-inflammatory effects in pre-eclampsia causes vasoconstriction, either directly through contracting smooth muscle or indirectly by inactivating nitric oxide and reducing the release of prostacyclin .Vasoconstriction is associated with slow blood flux and platelet activation. 12,13 Several indices are used to measure platelet activation and function these include platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT). These indices can be followed and used to predict pre-eclampsia as they are readily available. ...